Growth-Survival and Sodium Retaining Activity of 9 a-Halo Derivatives of Hydrocortisone

ANDROGENIC AND MYOTROPHIC PROPERTIES OF ORALLY ADMINISTERED 9-FLUORO-ll-OXY-METHYLTESTOSTERONES

“…Substitution of fluorine for hydrogen at C-9 has brought about remarkable changes in activity of a number of active adrenocorticoids and related compounds in the pregnane series (Fried and Sabo, 1953;Borman, Singer, and Numerof, 1954). This report shows that C-9 fluorine also enhances the activity of two 11-oxygenated androstane compounds, a surprising finding in view of the probable difference in metabolic pathways of the two types of steroid suggested by their different biological properties.…”

Effect of 9 -Fluorohydrocortisone on Adrenal Hyperfunction in Cushing's Syndrome

“…An interesting compound both for therapeutic use and for the investigation of many aspects of adrenal function was revealed when Fried and Sabo (1954) found that a halogen-substituted derivative of hydrocortisone, called 9a-fluorohydrocortisone, had strong cortisonelike activity in the rat-liver glycogen test. Borman et al (1954) have shown that this steroid has also strong sodium-retaining activity which has been estimated by Llaurado (1955) to be about ten times that of D.C.A. and about one-tenth of the activity of aldosterone itself, the naturally occurring electrolyte controlling hormone.…”

The Pituitary and Adrenals

“…Using the growth-survival and sodium-retaining tests, Borman, Singer & Nu merof (26) found the chI oro derivatives from ten to twenty times as active as DCA. The chloro derivative of both cortisone and hydrocortisone displayed surprising glucorticoid activity.…”