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159absence of exogenous sources of fluid, Na and C1, supports the view that one of the functions of the adrenal cortex is the regulatory control of the internal distribution of water and certain electrolytes between body compartments. The mechanism of action of the cortical steroids in effecting these changes remains an unsolved problem. Summary.2-methyl-9~-fluorohydrocortisone will revive adrenalectomized dogs from severe insufficiency and restore them to normal health within 48-60 hours even though they are deprived of food and water during recovery. The steroid fully corrects the distorted fluid and electrolyte equilibria of the blood. The lowered arterial pressure, serum Na and C1 increase to normal levels, the elevated serum K and blood urea nitrogen fall, while accompanying these changes, hemodilution occurs along with a diuresis and further loss of fluid, Na and C1. When adrenal hormones are lacking, water and salt are not only lost in urine and other excretions but perhaps equally important, are immobilized in cells and tissues. Following administration of potent steroid ample fluid and salt are redistributed to the extracellular and intra-vascular compartment with complete disappearance of symptoms and return of activity and vigor.

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Keccived December 29, 19.58. P.S.E.H.M., 1959, ~1 0 0 .