GSTT1, an increased risk factor for prostate cancer in patients with metabolic syndrome

Liu, Dongdong; Che, Bangwei; Chen, Pan; He, Jun; Mu, Yi; Chen, Kehang; Zhang, Wenjun; Xu, Shenghan; Tang, Kaifa

doi:10.1002/jcla.24352

Cited by 5 publications

(2 citation statements)

References 39 publications

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“…Recent studies have assessed the combined effects of GSTM1 and GSTT1 genotypes, but few studies have shown a significant association between the defects in these genes and prostate cancer risk [ 11 – 13 ]. Genes involved in oncogenic activation or detoxification have not yet been isolated, and more number of genes need to be assessed to fully understand this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

Association of Androgen-Receptor Gene Mutations with the Copy Number of Androgen-Receptor Silk Protein A Complex and Glutathione-S-Transferases T1 and M1 in Prostate Cancer Patients

Zhang

Meng

et al. 2023

Genetics Research

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Objective. The purpose of our work was to explore the association of mutations in the androgen receptor gene and copy numbers of the androgen-receptor silk protein A complex with glutathione-S-transferases T1 and M1 in prostate cancer patients. Materials and Methods. Eighty-five patients with PC and 85 healthy controls were included in the study. Fasting peripheral venous blood was collected, whole blood genomic DNA was extracted, and AR gene-receptor genotype was detected by a high-resolution melting curve analysis detection technology. Expression levels of androgen receptor (AR) and filamin protein A (FlnA) were detected by Western blotting. RT-PCR was used to detect the copy number of T1 and M1 glutathione-S-transferases. Results. The wild-type androgen receptor gene rs5918762 is of TT type. The frequencies of CC and TC genes in the prostate cancer group were significantly higher than those in the normal control group P < 0.05 . Compared with TT-type PC patients, PC patients with TC-type and CC-type had higher expression levels of sex hormone receptor silk protein A complex and higher copy numbers of GSTT1 and GSTM1 P < 0.05 . Androgen-receptor gene mutation (T ⟶ C) was significantly positively correlated with the expression level of androgen-receptor silk protein A complex and the copy number of GSTT1 and GSTM1. Conclusion. Androgen-receptor gene polymorphisms were significantly associated with expression levels of androgen receptor complex A and silk proteins, and copy numbers of T1 and M1 glutathione-S-transferases. A combination of four factors can be used to identify prostate cancer susceptibility and disease progression.

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Section: Discussionmentioning

confidence: 99%

Association of Androgen-Receptor Gene Mutations with the Copy Number of Androgen-Receptor Silk Protein A Complex and Glutathione-S-Transferases T1 and M1 in Prostate Cancer Patients

Zhang

Meng

et al. 2023

Genetics Research

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“…This gene is located on human chromosome 22q11.2, comprises five exons and is 8 kb long (Kerb et al., 2002; Nakanishi et al., 2022). Several diseases have been associated with gene expression and/or polymorphism of the GSTT1 enzyme, and they include pathologies such as sensitivity to mutagens, Type 2 diabetes mellitus, senile cataract, different carcinomas or de novo autoimmune hepatitis, among others (Al‐Riyami et al., 2022; Ansari‐Lari et al., 2020; Liu et al., 2022; Nassereddine et al., 2021; Nelson et al., 1995; Sobha & Ebenezar, 2021; Stepanova et al., 2021). Moreover, GSTT1 is also involved in activating the p38/MAPKAP kinase 2 (MK2) signal pathway.…”

Section: Introductionmentioning

confidence: 99%

Analysis of null deletion polymorphism of glutathione S‐transferase theta (GSTT‐1), associated with anti‐GSTT‐1 antibodies development in transplantation

Muro‐Perez,

González‐Martínez,

Martínez‐García

et al. 2023

Int J Immunogenetics

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Glutathione S‐transferase theta 1 (GSTT1) is an enzyme involved in phase II biotransformation processes and a member of a multigene family of detoxifying and clearing reactive oxygen species. GSTT1 is polymorphic like other biotransforming enzymes, allowing variability in hepatic conjugation processes. Immunological recognition of the GSTT1 alloantigen, as evidenced by donor‐specific antibodies formation, has previously been observed in recipients lacking GSTT1 protein (called GSTT1−, GSTT*0, null phenotype or homozygous for the GSTT1 deletion) who receive liver or kidney transplants from GSTT1+ donors and is a risk factor for the development of de novo hepatitis following liver transplants from a GSTT1 expressing donor. Antibodies against GSTT1 are demonstrated in patients who are GSTT1 null and received a transplant from a GSTT1+ donor. Understanding the local population frequency of the GSTT1 deletion is of value in understanding the potential clinical risk of developing post‐transplant complications, which can be attributed to the nonexpression of GSTT1. A population of 173 healthy donors of the Murcia Region in Southeast Spain was evaluated for a null allele of GSTT1 (n = 173). DNA was extracted, and GSTT‐1 null allele detection was performed by real‐time polymerase chain reaction. The frequency of the null GSTT1 genotype (nonexpression or deletion of the homozygous polymorphism of the GSTT1 protein) was 17.9% (n = 31 null allele GSTT1/173 total individuals). Our data suggest that the frequency of null GSTT1 mutations in our population in Southeast Spain is 17.9%, lower than in other Caucasoid populations. This would convert our recipient population into more susceptible to nonlocal potential organ donors and less susceptible to local donors. All recipients bearing this GSTT1 deletion homozygous would be without the protein and triggering an alloantigen in the case of transplantation with a donor without deletion.

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GSTT1, an increased risk factor for prostate cancer in patients with metabolic syndrome

Liu

Che

Chen

et al. 2022

Clinical Laboratory Analysis

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Background: Glutathione S-transferase (GSTs) gene polymorphism and metabolic syndrome (Mets) are generally considered to be risk factors for prostate cancer (PCa).However, this conclusion is still controversial. There is a close relationship between GSTs gene polymorphism and Mets. We suspect that the effect of GSTs gene polymorphism and Mets on PCa may be the result of their joint action. As a result, the purpose of this study was to investigate the potential effect of GSTs gene polymorphism on PCa in patients with Mets. Methods:We collected blood samples from 128 patients with PCa and 200 controls.The GSTs gene polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Age, characteristics of Mets, frequencies of GSTs gene polymorphism, total prostate volume (TPV), Gleason score, and prostate-specific antigen (PSA) were recorded and analyzed.Results: There were significant differences in BMI, TG, LDL-C, FBG, SBP, DBP, and HDL-C among the control group, N-PCa group, and Mets-PCa group (p < 0.05). GSTT1 null genotype (OR = 2.844, 95% CI: 1.791-4.517), GSTM1 null genotype (OR = 2.192, 95% CI: 1.395-3.446), and GSTP1 (A/G + G/G) genotype (OR = 2.315, 95% CI: 1.465-3.657) were associated with PCa susceptibility and malignancy. Only the GSTT1 null genotype in Mets patients was positively correlated with PCa. Conclusions:Our study suggests that GSTs gene polymorphism may be a risk factor for PCa and can predict the susceptibility and malignancy of PCa. Secondly, in Mets patients, GSTT1 null genotype significantly increased the risk of PCa. GSTM1 null genotype and the effect of GSTP1 (AG + GG) on PCa were not significantly related to Mets.

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GSTT1, an increased risk factor for prostate cancer in patients with metabolic syndrome

Cited by 5 publications

References 39 publications

Association of Androgen-Receptor Gene Mutations with the Copy Number of Androgen-Receptor Silk Protein A Complex and Glutathione-S-Transferases T1 and M1 in Prostate Cancer Patients

Association of Androgen-Receptor Gene Mutations with the Copy Number of Androgen-Receptor Silk Protein A Complex and Glutathione-S-Transferases T1 and M1 in Prostate Cancer Patients

Analysis of null deletion polymorphism of glutathione S‐transferase theta (GSTT‐1), associated with anti‐GSTT‐1 antibodies development in transplantation

GSTT1, an increased risk factor for prostate cancer in patients with metabolic syndrome

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