Guest-responsive supramolecular hydrogels expressing selective sol–gel transition for sulfated glycosaminoglycans

Kuroda, Naofumi; Tounoue, Yukie; Noguchi, Kouichiro; Shimasaki, Yutaro; Inokawa, Hitoshi; Takano, Masayoshi; Shinkai, Seiji; Tamaru, Shun Ichi

doi:10.1038/s41428-020-0341-x

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…Aqueous self-assembly of short peptides (di or tripeptides) has recently garnered growing interest due to their potential to fabricate nanomaterials for a variety of applications. [1][2][3][4][5][6][7][8] Phenylalanine (F) is one of the most common amino acid constituents used in such selfassembled nanostructures. [9][10][11][12][13][14][15][16] Pivotal works by Gazit and colleagues revealing that one-dimensional (1D) nanotubes can be obtained from aqueous self-assembly of a simple dipeptide (FF) [9,10] have significantly widened this research field.…”

Section: Introductionmentioning

confidence: 99%

Effect of side chain phenyl group on the self‐assembled morphology of dipeptide hydrazides

et al. 2020

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We report self-assembled nanostructures of dipeptides hydrazides, in which alanine and/or phenylalanine are employed as components to investigate the effect of the side chain phenyl group on the morphology of self-assembled nanostructures. We demonstrated that the dimensions of the self-assembled nanostructures can vary from 1D (fiber and tubular) to 2D (sheet) solely by adjusting the position of the side chain phenyl group in the simple molecular scaffold of the dipeptide hydrazides. This study highlights the significance and potential of systematic investigations for finetuning the morphology of aqueous self-assembled structures of the dipeptide hydrazides with the aim of exploring functional soft nanomaterials.

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Section: Introductionmentioning

confidence: 99%

Effect of side chain phenyl group on the self‐assembled morphology of dipeptide hydrazides

et al. 2020

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“…Many studies are being conducted on bioresponsive hydrogels that are useful in a variety of biomedical applications such as biosensing [ [1] , [2] , [3] ], controlled drug delivery [ [4] , [5] , [6] ], and tissue engineering [ [7] , [8] , [9] ], because of their specific responses to various external stimuli. Generally, bioresponsive hydrogels undergo swelling/shrinking or sol–gel transitions in response to physical (temperature, electric or magnetic fields, and mechanical stress) [ [10] , [11] , [12] , [13] ] or chemical (pH, metal ions, and other chemical molecules) stimuli [ [14] , [15] , [16] ].…”

Section: Introductionmentioning

confidence: 99%

Real-time and label-free biosensing using moiré pattern generated by bioresponsive hydrogel

Kim

et al. 2023

Bioactive Materials

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“…Stimuli-responsive hydrogels are capable of undergoing sharp and reversible volume change in response to external stimuli, such as physical (temperature, electric or magnetic fields, and mechanical stress) [1][2][3][4] or chemical (pH, metal ions, and other chemical molecules) stimuli [5][6][7]. They have been used as intelligent materials in many fields, especially in sensing [8], drug delivery [9], actuators [10], and chemical valves [11,12].…”

Section: Introductionmentioning

confidence: 99%

Multiple Responsive Hydrogel Films Based on Dynamic Phenylboronate Bond Linkages with Simple but Practical Linear Response Mode and Excellent Glucose/Fructose Response Speed

Tian

Song

et al. 2023

Polymers

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Multiple responsive hydrogels are usually constructed by the addition of many different functional groups. Generally, these groups have different responsive behaviors which lead to interleaved and complex modes of the multi-response system. It is difficult to get a practical application. In this study, we show that multi-response hydrogels can also be constructed using dynamic bonds as crosslinks. The multiple responsive hydrogel films with thicknesses on the sub-micrometer or micrometer scale can be fabricated from P(DMAA-3-AAPBA), a copolymer of N,N-dimethylacrylamide, 3-(acrylamido)phenylboronic acid, and poly(vinylalcohol) (PVA) though a simple layer-by-layer (LbL) technique. The driving force for the film build up is the in situ-formed phenylboronate ester bonds between the two polymers. The films exhibit Fabry–Perot fringes on their reflection spectra which can be used to calculate the equilibrium swelling degree (SDe) of the film so as to characterize its responsive behaviors. The results show that the films are responsive to temperature, glucose, and fructose with simple and practical linear response modes. More importantly, the speed of which the films respond to glucose or fructose is quite fast, with characteristic response times of 45 s and 7 s, respectively. These quick response films may have potential for real-time, continuous glucose or fructose monitoring. With the ability to bind with these biologically important molecules, one can expect that hydrogels may find more applications in biomedical areas in the future.

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Guest-responsive supramolecular hydrogels expressing selective sol–gel transition for sulfated glycosaminoglycans

Cited by 8 publications

References 34 publications

Effect of side chain phenyl group on the self‐assembled morphology of dipeptide hydrazides

Effect of side chain phenyl group on the self‐assembled morphology of dipeptide hydrazides

Real-time and label-free biosensing using moiré pattern generated by bioresponsive hydrogel

Multiple Responsive Hydrogel Films Based on Dynamic Phenylboronate Bond Linkages with Simple but Practical Linear Response Mode and Excellent Glucose/Fructose Response Speed

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