Guided tissue regeneration for implants placed into extraction sockets: a study in dogs

Becker, William; Be, Becker; Handelsman, M; Ochsenbein, Clifford; Albrektsson, Tomas

doi:10.1097/00008505-199200130-00014

Cited by 103 publications

(131 citation statements)

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“…Indeed, a high dose level of PDGF‐BB (> 300 µg/ml) was used to assist regenerative healing in critical‐sized peri‐implant defects (Choo et al ., ). Second, the release time point of PDGF‐BB from the Ti implant should be controlled, because the effects of PDGF‐BB appear to be most significant during the early stage of bone healing (Becker et al ., ; Lynch et al ., ; Nociti et al ., ; Stefani et al ., ). Thus, if we develop a Ti implant that can rapidly release PDGF‐BB within short time periods (1–2 weeks) and slowly release BMP‐2 over a period 6–8 weeks, more favourable outcomes of the combination of two growth factors can be achieved.…”

Section: Discussionmentioning

confidence: 98%

Co-delivery of platelet-derived growth factor (PDGF-BB) and bone morphogenic protein (BMP-2) coated onto heparinized titanium for improving osteoblast function and osteointegration

Kim

Yun

Lee

et al. 2013

J Tissue Eng Regen Med

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The aim of this study was to improve osteoblast function by delivering two growth factors, PDGF-BB and BMP-2, incorporated onto heparinized titanium (Hep-Ti) substrate. To achieve co-delivery of PDGF-BB and BMP-2, the surface of anodized Ti was immobilized with heparin, and then the two growth factors were coated onto the Hep-Ti surface. Incorporation of the two growth factors onto Hep-Ti was evaluated by SEM and XPS. Incorporated PDGF-BB and BMP-2 were released from the Hep-Ti substrate in a sustained manner. In vitro studies revealed that osteoblasts grown on PDGF-BB- and BMP-2-immobilized Hep-Ti increased ALP activity, calcium deposition, osteocalcin and osteopontin levels as compared to those grown on PDGF-BB alone- or BMP-2 alone-immobilized Hep-Ti. These results suggested that co-delivery of PDGF-BB and BMP-2 using Hep-Ti substrate will be a promising material for the enhancement of osteoblast function and osteointegration.

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Section: Discussionmentioning

confidence: 98%

Co-delivery of platelet-derived growth factor (PDGF-BB) and bone morphogenic protein (BMP-2) coated onto heparinized titanium for improving osteoblast function and osteointegration

Kim

Yun

Lee

et al. 2013

J Tissue Eng Regen Med

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“…Effectiveness of e‐PTFE membranes was investigated in numerous clinical studies, that confirmed their excellent biocompatibility, leading to a significant bone regeneration after 3‐ and 6‐month healing period [15, 16]. However, drawbacks of e‐PTFE membranes are (i) the need for a second surgical procedure and (ii) membrane stiffness that may result in soft tissue dehiscence (which is the cause of failure during the first 3 weeks after membrane implantation), allowing the exposure of the membrane to bacterial infection [17–19].…”

Section: Commercially Available Membranes For Bone Regenerationmentioning

confidence: 99%

Polymeric membranes for guided bone regeneration

Gentile

Chiono

Tonda‐Turo

et al. 2011

Biotechnology Journal

269

189

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In this review, different barrier membranes for guided bone regeneration (GBR) are described as a useful surgical technique to enhance bone regeneration in damaged alveolar sites before performing implants and fitting other dental appliances. The GBR procedure encourages bone regeneration through cellular exclusion and avoids the invasion of epithelial and connective tissues that grow at the defective site instead of bone tissue. The barrier membrane should satisfy various properties, such as biocompatibility, non-immunogenicity, non-toxicity, and a degradation rate that is long enough to permit mechanical support during bone formation. Other characteristics such as tissue integration, nutrient transfer, space maintenance and manageability are also of interest. In this review, various non-resorbable and resorbable commercially available membranes are described, based on expanded polytetrafluoroethylene, poly(lactic acid), poly(glycolic acid) and their copolymers. The polyester-based membranes are biodegradable, permit a single-stage procedure, and have higher manageability than non-resorbable membranes; however, they have shown poor biocompatibility. In contrast, membranes based on natural materials, such as collagen, are biocompatible but are characterized by poor mechanical properties and stability due to their early degradation. Moreover, new approaches are described, such as the use of multi-layered, graft-copolymer-based and composite membranes containing osteoconductive ceramic fillers as alternatives to conventional membranes.

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“…Advances in biomaterial technology over the past three decades have led to redefinitions of the term “osseointegration” based on patients' increasing expectations for reduced treatment time and improved esthetics and comfort. The advantages associated with reduction of healing time by immediate implant placement into fresh extraction sockets has been previously described . It has been claimed that survival rates of immediate implants are comparable to those of delayed implants providing that good primary stability is achieved .…”

Section: Introductionmentioning

confidence: 99%

“…The advantages associated with reduction of healing time by immediate implant placement into fresh extraction sockets has been previously described . It has been claimed that survival rates of immediate implants are comparable to those of delayed implants providing that good primary stability is achieved . In addition to reducing the number of surgical procedures, immediate implantation reduces or even eliminates the load‐free healing period following implant placement.…”

Section: Introductionmentioning

confidence: 99%

Esthetic Assessment of Implants Placed into Fresh Extraction Sockets for Single‐Tooth Replacements Using a Flapless Approach

Kolerman

Mijiritsky

Barnea³

et al. 2016

Clin Implant Dent Rel Res

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Guided tissue regeneration for implants placed into extraction sockets: a study in dogs

Cited by 103 publications

References 0 publications

Co-delivery of platelet-derived growth factor (PDGF-BB) and bone morphogenic protein (BMP-2) coated onto heparinized titanium for improving osteoblast function and osteointegration

Co-delivery of platelet-derived growth factor (PDGF-BB) and bone morphogenic protein (BMP-2) coated onto heparinized titanium for improving osteoblast function and osteointegration

Polymeric membranes for guided bone regeneration

Esthetic Assessment of Implants Placed into Fresh Extraction Sockets for Single‐Tooth Replacements Using a Flapless Approach

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