Guided tissue regeneration using rigid absorbable membranes in the dog model of chronic furcation defect

Reis, Emily Correna Carlo; Borges, Andréa Pacheco Batista; Carlo, Ricardo Junqueira Del; Oliveira, Paulo Miranda de; Sepúlveda, Rodrigo Viana; Fernandes, Natália Alves; Martins, Lívia Marina Alvarenga; Carvalho, Tatiana Borges

doi:10.3109/00016357.2012.680909

Cited by 11 publications

(9 citation statements)

References 30 publications

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“…While the characteristics of bioabsorbable barriers accelerate their biodegradation, negative outcomes may also be observed for the exposure of absorbable membranes to the oral cavity . Recently, Carlo Reis et al developed an absorbable but rigid membranes (made of hydroxyapatite and polyhydroxybutyrate matrix) aiming at preventing their collapse into the defect during periodontal regeneration of class II furcation defects in dogs. In line with the previous mentioned studies, these authors observed that although partial regeneration of the defect has been achieved, it was limited by membrane exposure and wound contamination.…”

Section: Eptfe Membrane Exposure/retrieval Timementioning

confidence: 89%

Experimental and clinical studies on regenerative periodontal therapy

Sallum

Ribeiro

Ruiz

et al. 2019

Periodontology 2000

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bone substitutes, enamel matrix proteins, guided tissue regeneration, periodontal, regeneration, tissue engineering | INTRODUC TI ONThe purpose of this chapter of Periodontology 2000 is to review the research carried out in Latin America in the field of periodontal regeneration, focusing mainly on studies using preclinical models (animal models) and randomized controlled clinical trials. It has been organized to reflect the information produced by Latin American research groups, which are accompanied by the appropriate references. The specific questions raised by these groups were explored in each subtopic, based on the results. Therefore, a complete review of this topic is not within the scope of this text as other reviews covering regenerative therapies are available in the literature. [1][2][3][4][5][6][7][8]

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Section: Eptfe Membrane Exposure/retrieval Timementioning

confidence: 89%

Experimental and clinical studies on regenerative periodontal therapy

Sallum

Ribeiro

Ruiz

et al. 2019

Periodontology 2000

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“…The experimental model is commonly used in much of the literature, as Chantarawaratit et al reported that acemannan significantly accelerates new alveolar bone, cementum and periodontal ligament formation in class II furcation defects [37]. Reis et al reported that rigid membranes made of 25% or 35% hydroxyapatite and polyhydroxybutyrate partially improved the regeneration of class II furcation defects in dogs, but an inflammatory infiltrate was also observed in the dense connective tissue [38]. Figures 7 and 8 show that in our study, the percentage of new bone formation in the Col/BG/CS group was higher than that of the control group at 30 and 60 d, and bone matrix protein (OCN) was presented in the newly formed bone.…”

Section: Discussionmentioning

confidence: 99%

Development of fish collagen/bioactive glass/chitosan composite nanofibers as a GTR/GBR membrane for inducing periodontal tissue regeneration

Zhou¹,

Liu²,

Sui³

et al. 2017

Biomed. Mater.

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The development of a guided tissue or bone regeneration (GTR/GBR) membrane with excellent performance has been a major challenge in the biomedical field. The present study was designed to prepare a biomimetic electrospun fish collagen/bioactive glass/chitosan (Col/BG/CS) composite nanofiber membrane and determine its structure, mechanical property, antibacterial activity, and biological effects on human periodontal ligament cells (HPDLCs). The effects of this composite membrane on inducing periodontal tissue regeneration were evaluated using a dog class II furcation defect model. It was found that the composite membrane had a biomimetic structure with good hydrophilicity (the contact angle was 12.83 ± 3°) and a tensile strength of 13.1 ± 0.43 Mpa. Compared to the pure fish collagen membrane, the composite membrane showed some degree of antibacterial activity on Streptococcus mutans. The composite membrane not only enhanced the cell viability and osteogenic gene expression of the HPDLCs, but also promoted the expression of RUNX-2 and OPN protein. Further animal experiments confirmed that the composite membrane was able to promote bone regeneration in the furcation defect of dogs. In conclusion, a biomimetic fish Col/BG/CS composite membrane has been developed in the present study, which can induce tissue regeneration with a certain degree antibacterial activity, providing a basis for potential application as a GTR/GBR membrane.

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“…Seventeen studies providing data on the effect of OFD in animal class II furcation defects were identified (Table 4) [39,53,55,57,69,71,75,76,78,99,101,102,112,114,115,118,120]. The majority of the studies (i.e., 11 out 16) showed long junctional epithelium, whereas new cementum, PDL and/or new alveolar bone were observed only in a few cases at the apical limit of the defect [28-34, 36, 38, 39, 43].…”

Section: Animal Class II Furcation Defects Treated With Ofdmentioning

confidence: 99%

“…Fourteen studies providing data on the effect of the use of GTR in animal class II furcation defects were identified (Table 8). Six studies used resobable membranes [69,71,72,89,102,112], five studies used non-resorbable membranes [53,54,56,57,119], and three studies combined resorbable and non-resorbable membranes [55,70,114].…”

Section: Animal Class II Furcation Defects Treated With Ofd and Gtrmentioning

confidence: 99%

Histologic evidence of periodontal regeneration in furcation defects: a systematic review

Laugisch

Cosgarea

Nikou³

et al. 2019

Clin Oral Invest

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Objective To systematically review the available histologic evidence on periodontal regeneration in class II and III furcations in animals and humans. Materials and methods A protocol including all aspects of a systematic review methodology was developed including definition of the focused question, defined search strategy, study inclusion criteria, determination of outcome measures, screening methods, data extraction and analysis, and data synthesis. The focused question was defined as follows: BWhat is the regenerative effect obtained by using or not several biomaterials as adjuncts to open flap surgery in the treatment of periodontal furcation defects as evaluated in animal and human histological studies?Ŝ earch strategy Using the MEDLINE database, the literature was searched for articles published up to and including September 2018: combinations of several search terms were applied to identify appropriate studies. Reference lists of review articles and of the included articles in the present review were screened. A hand search of the most important dental journals was also performed. Criteria for study selection and inclusion Only articles published in English describing animal and human histological studies evaluating the effect of surgical treatment, with or without the adjunctive use of potentially regenerative materials (i.e., barrier membranes, grafting materials, growth factors/proteins, and combinations thereof) for the treatment of periodontal furcation defects were considered. Only studies reporting a minimum of 8 weeks healing following reconstructive surgery were included. The primary outcome variable was formation of periodontal supporting tissues [e.g., periodontal ligament, root cementum, and alveolar bone, given as linear measurements (in mm) or as a percentage of the instrumented root length (%)] following surgical treatment with or without regenerative materials, as determined histologically/histomorphometrically. Healing type and defect resolution (i.e., complete regeneration, long junctional epithelium, connective tissue attachment, connective tissue adhesion, or osseous repair) were also recorded. Results In animals, periodontal regeneration was reported in class II and III defects with open flap debridement alone or combined with various types of bone grafts/bone substitues, biological factors, guided tissue regeneration, and different combinations thereof. The use of biological factors and combination approaches provided the best outcomes for class II defects whereas in class III defects, the combination approaches seem to offer the highest regenerative outcomes. In human class II furcations, the best outcomes were obtained with DFDBA combined with rhPDGF-BB and with GTR. In class III furcations, evidence from two case reports indicated very limited to no periodontal regeneration.

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Guided tissue regeneration using rigid absorbable membranes in the dog model of chronic furcation defect

Abstract: Although partial regeneration of the defect was observed, it was limited by wound contamination. Consequently, rigid absorbable membranes made of HA and PHB failed to improve the regeneration of class II furcation defects in dogs.

Cited by 11 publications

References 30 publications

Experimental and clinical studies on regenerative periodontal therapy

Experimental and clinical studies on regenerative periodontal therapy

Development of fish collagen/bioactive glass/chitosan composite nanofibers as a GTR/GBR membrane for inducing periodontal tissue regeneration

Histologic evidence of periodontal regeneration in furcation defects: a systematic review

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