Guillain-Barre Syndrome Following Dengue Fever in Adult Patient

Qureshi, NK; Begum, Afsana; Saha, PR; Hossain, MI

doi:10.3329/jom.v13i2.12772

Cited by 17 publications

(32 citation statements)

References 21 publications

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“…Previous evidence suggests the association between arbovirus infection and GBS [19][20][21][22][23][24][25]. Regarding the frequent and intense dengue, chikungunya, and Zika epidemics, there are few cases described involving neurological complications associated with infection by these viruses.…”

Section: Discussionmentioning

confidence: 99%

Guillain-Barré syndrome associated with arboviruses in the state of Pernambuco in 2016

2019

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Introduction: In 2016, Brazil presented an increase in the notifications related to neurological syndromes with previous register of a febrile illness compatible with arboviruses, including Guillain-Barré syndrome (GBS). Such disease is responsible for the most frequent occurrence of flaccid paralysis in the world, causing bilateral ascending muscle weakness that might affect the respiratory tract. Objective: To investigate the incidence of Guillain-Barré syndrome associated with arboviruses in Pernambuco in 2016 and to describe the confirmed/probable cases. Method: This is an observational retrospective study of GBS cases with a background of infection from dengue, chikungunya, or Zika virus notified to the Pernambuco Health State Secretariat (SES-PE). Cases notified from January 1st to December 31st, 2016 were included, which were considered as possible GBS at the time of notification. The suspect cases were investigated and classified as confirmed/probable by the positive laboratory test result, excluding the possibility of infection. Results: Forty-three suspect cases of GBS after previous arbovirus infection were notified. From these, 23 were classified as confirmed/probable for the etiological agents chikungunya and/or dengue. The mean age of the affected individuals was 37.22 ± 21.29 years and they were mostly female (56.5%). The annual incidence of GBS after arbovirus infection was 0.24 cases per 100 thousand inhabitants in the state. The neurological condition was mainly characterized by the presence of movement (91.3%) and walking (78.3%) alterations. Conclusion: The findings of this research confirm the current set of evidence and show the likelihood of GBS being a severe neurological complication of these arboviruses.

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Section: Discussionmentioning

confidence: 99%

Guillain-Barré syndrome associated with arboviruses in the state of Pernambuco in 2016

2019

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“…As the incidence of dengue and DHF is increasing, unusual manifestations are on the rise, although they are being under reported due to the lack of awareness [ 3 ]. Neurological manifestations so far reported include depression, convulsions, encephalopathy, encephalitis, aseptic meningitis, intracranial haemorrhage, intracranial thrombosis, myelitis, mononeuropathies, polyneuropathies, hemifacial spasm, peripheral facial paralysis and Guillain–Barre syndrome (GBS) [ 3 – 5 ]. GBS or acute inflammatory demyelinating polyradiculopathy (AIDP) is a post infectious ascending, usually demyelinating, polyradiculoneuropathy accompanied by areflexia, motor paralysis, and elevated cerebro spinal fluid (CSF) total protein without pleocytosis [ 5 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Well established associations with GBS are recent infections with Campylobacter jejuni , Cytomegalo virus, Epstein–Barr virus, Mycoplasma pneumonia , HIV. But dengue fever (DF) as an antecedent infection in GBS is uncommon [ 5 , 10 , 11 ]. Several previous reports have described GBS in patients with dengue [ 3 , 5 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Guillain–Barre syndrome following dengue fever and literature review

2015

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BackgroundDengue is an arboviral infection that classically presents with fever, joint pain, headaches, skin flush and morbilliform rashes. The incidence of neurological symptoms and complications in dengue varies from 1 to 25 % that include encephalopathy, Guillain–Barre syndrome (GBS), acute motor weakness, seizures, neuritis, hypokalaemic paralysis, pyramidal tract signs, and a few more. Dengue fever as an antecedent infection in GBS is uncommon.Case presentationA 34-years-old Sri Lankan Sinhalese male presented with fever, headache and myalgia of 3 days and developed leucopenia and thrombocytopenia without evidence of haemoconcentration. The diagnosis of dengue fever was confirmed as he had positive dengue NS1 antigen test on the third day of fever. He made full recovery and was discharged after 4 days of hospital stay. Six days later, he presented with history of acute flaccid weakness of both lower limbs and upper limbs which was of progressive ascending nature. The electromyography had evidence of demyelinating neuropathy and cerebrospinal fluid showed albuminocytological dissociation. Subsequently, IgM for dengue virus was positive.ConclusionDengue is endemic in Sri Lanka. Post dengue Guillain–Barre syndrome is a potential neurological complications of this infection.

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“…The spectrum includes encephalitis, myositis, myelitis, GBS and mononeuropathies 5. GBS or acute inflammatory demyelinating polyradiculopathy is a postinfectious ascending, usually demyelinating, polyradiculoneuropathy 6. Well-established associations with GBS are recent infections with Campylobacter jejuni , cytomegalovirus, Epstein-Barr virus, Mycoplasma pneumonie and HIV.…”

Section: Discussionmentioning

confidence: 99%

“…Dengue fever as an antecedent infection in GBS was uncommon a decade back; however, several authors have increasingly described GBS in dengue, majority of these being children and a few cases of postdengue GBS in adults 6 7. It is suggested that the clinical manifestations of GBS in dengue result from an abnormal immune response to non-self antigens which can cross-react with the myelin or axons of peripheral nerves via molecular mimicry 8.…”

Section: Discussionmentioning

confidence: 99%

Concurrent Guillain-Barré syndrome and myositis complicating dengue fever

et al. 2020

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Dengue is an arboviral infection that classically presents with fever, headache, joint pain, skin flush and morbilliform rashes. Neurological manifestations are well recognised but their exact incidence is unknown. Though myalgias are common in dengue virus infection, myositis and/or elevated serum creatine kinase is an uncommon complication. Guillain-Barré syndrome is another rare neurological manifestation associated with dengue fever. Here, we report the case of a 21-year-old man with serologically confirmed dengue fever presenting with severe myalgia, bilateral lower and upper limb weakness with raised creatine kinase, MRI suggestive of myositis and myonecrosis and nerve conduction velocity showing bilateral lower limb and axillary sensory motor neuropathy. He was managed conservatively and made an uneventful recovery.

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Guillain-Barre Syndrome Following Dengue Fever in Adult Patient

Cited by 17 publications

References 21 publications

Guillain-Barré syndrome associated with arboviruses in the state of Pernambuco in 2016

Guillain-Barré syndrome associated with arboviruses in the state of Pernambuco in 2016

Guillain–Barre syndrome following dengue fever and literature review

Concurrent Guillain-Barré syndrome and myositis complicating dengue fever

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