Guillain-Barre syndrome is a post infectious ascending, usually demyelinationg polyradiculoneuropathy. Dengue fever as an antecedent infection in GBS is uncommon. A 39-year-old female presented with acute flaccid weakness of both upper and lower limbs which developed in ascending and progressive fashion following a febrile illness of three days. During work-up IgM for dengue virus was found positive. Diagnosis of Guillain-Barre syndrome was made based on neurologic manifestations, the typical CSF findings and pattern of electrophysiological study and exclusion of other pathologies. Patient was treated with intravenous immunoglobulins. During the course of illness, she developed lower motor neuron type trigeminal, facial, glossopharyngeal, vagus and hypoglossal nerve palsy and autonomic involvement. She had significant recovery and was able to talk, eat and walk six weeks later. Dengue is endemic in Bangladesh. Post dengue Guillain- Barre syndrome in adult, as shown in previous reports, should now be considered in the part of spectrum of neurological complications of this infection. DOI: http://dx.doi.org/10.3329/jom.v13i2.12772 J Medicine 2012; 13 : 246-249

Pregnancy is accompanied by profound alteration of thyroid economy and relative iodine deficiency. Sub-optimal thyroid function in pregnancy is associated with impaired neuro intellectual development. Urinary iodine concentration is increased during pregnancy. The aims of this study were to evaluate urinary iodine level in pregnant women and also to elucidate its correlation with thyroid parameters (TSH&FT4) in pregnancy. This was a case control study carried out in the Department of Biochemistry, jointly with the Antenatal and Thyroid Clinic of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, during the period of July 2003 to June 2004. Urinary iodine excretion was measured in 100 subjects of age range 20-35 years. Among them 60 were pregnant at first trimester and primi gravid. Rest 40 were non-pregnant women who were taken as control. Urinary iodine was measured by Wet digestion based on Sandell-Kolthoff principle. Thyroid Stimulating hormone (TSH) and free thyroxin (FT4) were measured by the AxSYM (Abbott -USA) by applying Micro particle Enzyme Immune Assay (MEIA) principle. The data was reported as Mean± SE; the mean age of the pregnant and nonpregnant women were 25.03±0.48 yrs and 25.20±0.60 yrs respectively. No significant difference was found regarding age. The median urinary iodine of pregnant women was 438.13µg/l (range240.50-490.0) and that non pregnant women was 412.50µg/l (range 240.0-473.75µgl). Mean serum TSH were 1.29±0.15 and 1.97±0.18 mIU/L and mean serum FT4 were 14.51±0.41 and 16.30 ±0.41pmol/L in pregnant and non pregnant women respectively. Urinary iodine level was significantly increased in pregnant women compared to that of the non pregnant group (p<0.05). A significant negative correlation was found between urinary iodine and serum TSH (p<0.01) whereas a positive correlation between urinary iodine and serum FT4 level is p<0.05 in pregnant and p<0.01 in non pregnant group. Urinary iodine excretion is increased in pregnancy than that in non pregnant women. Clinically and biochemically all the subjects were euthyroid and excretion rate of iodine in all subjects were above the normal range.Bangladesh J Med Biochem 2015; 8(1): 21-26

An elevated serum homocysteine concentration is associated with an increased risk of coronary, cerebral, and peripheral vascular disease. The objective of the study was to evaluate the association of serum homocysteine level with hypertension (HTN). This cross sectional analytical study was conducted at Sir Salimullah Medical College & Mitford Hospital and National Health Care Network Dhaka, Bangladesh over a duration of 21 months from July 2012 to May 2014. Fifty HTN patients were included as study subjects and age and sex matched fifty non-HTN healtlhy controls were included. All the clinical measurements were taken and serum Hcy was measured for all study subjects. In this study, females were predominant in both groups, mean age of the HTN patients was 41.0±5.6 years and non-HTN healthy subjects was 38.2±5.2 years. BMI and FBG were found higher in HTN group than that of non-HTN group but the differences were not statistically significant. Systolic and diastolic BP were found significantly higher in HTN group than that of non-HTN group. Serum Hcy level was significantly higher in HTN group (19.93±4.12 μmol/L) than that of non-HTN group (13.20±1.88 μmol/L). This study depicted that serum Hcy had significant correlation with SBP and DBP in HTN. In conclusion, it was seen that elevated serum Hcy level is associated with hytpertension. Bangladesh J Med Biochem 2018; 11(1): 22-25