Gut-liver axis in cirrhosis: Are hemodynamic changes a missing link?

Maslennikov, Roman; Ивашкин, В. Т.; Efremova, Irina; Poluektova, Elena; Широкова, Е. Н.

doi:10.12998/wjcc.v9.i31.9320

Cited by 23 publications

(31 citation statements)

References 73 publications

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“…Moreover, left ventricular EF showed no significant difference between the different groups. In agreement with our findings, many previous [22][23][24][25]. Contrarily, other researchers noted a significant increase in the incidence of systolic dysfunction, especially when the individuals were exposed to stress, including sodium load, erect posture, or exercise [22,24,26,27].…”

Section: Discussionsupporting

confidence: 92%

“…Contrarily, other researchers noted a significant increase in the incidence of systolic dysfunction, especially when the individuals were exposed to stress, including sodium load, erect posture, or exercise [22,24,26,27]. The decreased myocardial reserve, weakened heart rate response to stress, and impaired oxygen extraction at cardiac muscle could explain the previous dysfunction [22,28].…”

Section: Discussionmentioning

confidence: 99%

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Comparative evaluation of cardiac health in patients with chronic liver disease secondary to HCV, HBV, and NASH

Omar

Zaghla

Omara

et al. 2022

ijhs

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Background: There is a documented relationship between chronic liver disease and cardiac dysfunction. The current investigation aims to compare the cardiac health in patients with chronic liver disease secondary to HCV, HBV, and NASH. Patients and Methods: This prospective study included 150 patients divided into three groups; Group I (50 HCV cases), Group II (50 HBV cases), and Group III (50 NASH cases). Each group was subdivided into two equal subgroups; the A subgroup included patients without liver cirrhosis, and the B subgroup included patients with liver cirrhosis. The assessment included laboratory biomarkers, transabdominal ultrasound, fibroscan, echocardiography, and carotid doppler. Results: EF had mean values of 62.58, 62.8, and 64.14%, whereas prolonged QT interval was noted in 30%, 40%, and 37% of patients in the three groups, respectively. E/A ratios > 1 were detected in 70%, 66%, and 72% of patients, while carotid atherosclerosis was detected in 28%, 28%, and 32% in the same three groups, respectively. All of the previous parameters were comparable between the three main groups. On comparing subgroups A to B, prolonged QT intervals, carotid atherosclerosis, and decreased EF were more noticed in the latter.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of cardiac health in patients with chronic liver disease secondary to HCV, HBV, and NASH

Omar

Zaghla

Omara

et al. 2022

ijhs

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“…Diets high in saturated fat and fructose affect the composition of the gut flora [ 181 ]. The resulting dysbiosis leads to a cascade of events including increased intestinal barrier permeability, bacterial translocation, and activation of hepatic receptor-induced inflammation [ 182 ]. One proposed mechanism pertains to the production of endogenous alcohol and acetaldehyde [ 183 , 184 , 185 ].…”

Section: Therapeutic Applications Of Probioticsmentioning

confidence: 99%

Effects of Probiotic Supplementation during Pregnancy on the Future Maternal Risk of Metabolic Syndrome

Obuchowska

GORCZYCA

Standyło

et al. 2022

IJMS

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Probiotics are live microorganisms that induce health benefits in the host. Taking probiotics is generally safe and well tolerated by pregnant women and their children. Consumption of probiotics can result in both prophylactic and therapeutic effects. In healthy adult humans, the gut microbiome is stable at the level of the dominant taxa: Bacteroidetes, Firmicutes and Actinobacteria, and has a higher presence of Verrucomicrobia. During pregnancy, an increase in the number of Proteobacteria and Actinobacteria phyla and a decrease in the beneficial species Roseburia intestinalis and Faecalibacterium prausnitzii are observed. Pregnancy is a “window” to the mother’s future health. The aim of this paper is to review studies assessing the potentially beneficial effects of probiotics in preventing the development of diseases that appear during pregnancy, which are currently considered as risk factors for the development of metabolic syndrome, and consequently, reducing the risk of developing maternal metabolic syndrome in the future. The use of probiotics in gestational diabetes mellitus, preeclampsia and excessive gestational weight gain is reviewed. Probiotics are a relatively new intervention that can prevent the development of these disorders during pregnancy, and thus, would reduce the risk of metabolic syndrome resulting from these disorders in the mother’s future.

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“…Научный интерес к микробиоте кишечника совпал с глобальным увеличением распространенности заболеваний печени. Микробиота кишечника, которую также иногда называют "новым метаболическим органом", теснейшим образом связана с печенью множеством метаболических реакций [17,18,19,20].…”

Section: результаты исследованияunclassified

Pathogenetic bases of the combined use of drugs from the groups of hepatoprotectors and phytosorbents

Alekhin

Ponamarev²,

Popova³

2022

jour

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The combined use of hepatoprotectors and phytosorbents in theory is a promising method of pharmacotherapy of comorbid pathologies, as it creates the possibility of presenting them as the result of an extended search for the most relevant forms of manifestation of metabolic disorders, the results of which made it possible to identify general patterns of development and, accordingly, the main directions for their leveling.It was revealed that the main pathogenetic trend is the failure of metabolic processes in the gastrointestinal tract, which reduces the efficiency of feeding and causes a decrease or fluctuations in productivity (or product quality), the subsequent accumulation of products of disturbed metabolic processes with toxic properties - the development of a local syndrome of endogenous intoxication, a violation of the processes of cavitary and symbiotic digestion in the gastrointestinal tract, with increased alimentary insufficiency, functional overload of the digestive organs and primarily the liver, imbalance of the microbiota and local barrier mechanisms, generalization of the pathological process in the form of the development of systemic endogenous intoxication with the corresponding toxic depression of immunity, functions of organs and body systems, including including dysfunctions and the development of pathology of the hepatobiliary system, in the form of systemic metabolic disorders with the occurrence of a secondary deficiency of nutrients and biologically active substances, acid disorders butalkaline balance and dystrophic phenomena.The main purpose of this article is, based on the analysis of literary sources, to identify the pathogenetic basis for the combined use of drugs from the hepatoprotector groups and phytosorbents.We searched for original studies in the scientific databases PubMed, Elsevier Science (Scopus) and Clarivate Analytics (Web of Science) over the past 20 years to identify the features of the above processes, after which a formalized content analysis of the found publications was carried out.A better understanding of the various mechanisms involved in pathogenesis involving the liver and intestinal microbiota will contribute to the development of improved pharmacological approaches to the treatment of these pathologies.

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Gut-liver axis in cirrhosis: Are hemodynamic changes a missing link?

Cited by 23 publications

References 73 publications

Comparative evaluation of cardiac health in patients with chronic liver disease secondary to HCV, HBV, and NASH

Comparative evaluation of cardiac health in patients with chronic liver disease secondary to HCV, HBV, and NASH

Effects of Probiotic Supplementation during Pregnancy on the Future Maternal Risk of Metabolic Syndrome

Pathogenetic bases of the combined use of drugs from the groups of hepatoprotectors and phytosorbents

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