Gut Microbiome: A Promising Biomarker for Immunotherapy in Colorectal Cancer

Temraz, Sally; Nassar, Farah; Nasr, Rihab; Charafeddine, Maya; Mukherji, Deborah; Shamseddine, Ali

doi:10.3390/ijms20174155

Cited by 95 publications

(74 citation statements)

References 72 publications

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“…Human microbial profiling offers a variety of understanding of the complicated interplay between the host and microbes in several diseases [ 32 , 33 , 34 , 35 , 36 , 37 ]. In addition, dysbiosis of microbial composition is potentially considered biomarkers of cancer [ 38 , 39 ]. A previous research performed on human subjects suggested microbial markers of women’s cervical cancer from fecal samples [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Potential Association between Vaginal Microbiota and Cervical Carcinogenesis in Korean Women: A Cohort Study

et al. 2021

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Convincing studies demonstrated that vaginal flora is one of the most impactful key components for the well-being of the genital tract in women. Nevertheless, the potential capability of vaginal-derived bacterial communities as biomarkers to monitor cervical carcinogenesis (CC) has yet to be studied actively compared to those of bacterial vaginosis (BV). We hypothesized that vaginal microbiota might be associated with the progression of CC. In this study, we enrolled 23 participants, including healthy controls (HC group; n = 7), patients with cervical intraepithelial neoplasia (CIN) 2 and 3 (CIN group, n = 8), and patients with invasive cervical cancer (CAN group; n = 8). Amplicon sequencing was performed using the Ion Torrent PGM to characterize the vaginal microbiota. Patients with CIN and CAN presented vaginal microbiota dysbiosis compared with HC. The alpha diversity analysis revealed that CC has a trend to be increased in terms of diversity indexes. Moreover, CC was associated with the abundance of specific microbes, of which Lactobacillus and Gardnerella were the most significantly different between HC and CIN, whereas Streptococcus was differentially abundant in CAN compared with CIN. We then evaluated their diagnostic abilities. Testing in terms of diagnostic ability using the three genera revealed considerably high performance with an area under the receiver-operating characteristic curve of 0.982, 0.953, and 0.922. The current study suggests that the presence of Gardnerella and Streptococcus may be involved in the advancment of CC.

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Section: Discussionmentioning

confidence: 99%

Potential Association between Vaginal Microbiota and Cervical Carcinogenesis in Korean Women: A Cohort Study

et al. 2021

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“…Evidence suggest a potential relationship between Fn and resistance to 5-fluorouracil chemotherapy (which is a standard treatment for advanced CRC patients) and ox-Pathobiology 2021;88:127-140 DOI: 10.1159/000512175 aliplatin and no response to immunotherapy [91][92][93][94]. Zhang et al [92] also observed, in advanced CRC patients who received standard 5-fluorouracil-based adjuvant chemotherapy, that a high Fn abundance is an independent risk factor for recurrence.…”

Section: Fn and Therapy Response Prediction And Perspectives For Treamentioning

confidence: 99%

The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis

et al. 2020

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Colorectal cancer (CRC) is one of the most frequent and deadly neoplasms worldwide. Genetic factors, lifestyle habits, and inflammation are important risk factors associated with CRC development. In recent years, growing evidence has supporting the significant role of the intestinal microbiome in CRC carcinogenesis. Disturbances in the healthy microbial balance, known as dysbiosis, are frequently observed in these patients. Pathogenic microorganisms that induce intestinal dysbiosis have become an important target to determine the role of bacterial infection in tumorigenesis. Interestingly, the presence of different bacterial strains, such as Fusobacterium nucleatum, has been detected in tissue and stool from patients with CRC and associated with substantial clinical and molecular features, as well as with patient therapy response. Therefore, understanding how the presence and levels of F. nucleatumstrains in the gut affect the risk of CRC onset and progression may inform suitable candidates for interventions focused on modulation of this bacteria. Here we review new insights into the role of gut microbiota in CRC carcinogenesis and the clinical utility of using the detection of F. nucleatum in different settings such as screening, prognosis, and microbiota modulation as a means to prevent cancer, augment therapies, and reduce adverse effects of treatment.

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“…Thus, patients with high MSI tumors represent a subgroup more likely to benefit from ICIs [ 161 ], and specific commensal gut bacteria have been implicated in the efficacy of ICIs [ 163 ]. Indeed, the commensal gut genus Bifidobacterium was associated with a clinical benefit for PD-L1 checkpoint blockade, and the use of antibiotics was shown to induce dysbiosis of gut microbiota with subsequent unresponsiveness to immunotherapy [ 164 , 165 ]. A recent study identified a consortium of 11 bacteria that act together to induce IFNγ+ CD8 T cells, enhanced resistance against pathogenic infections and improved the therapeutic efficacy of ICIs in mice [ 166 ].…”

Section: The Human Gut Microbiota As Crc Predisposing Factor: Thermentioning

confidence: 99%

Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer

Mori

Pasca

2021

IJMS

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Colorectal cancer (CRC) is the fourth most common cause of cancer-related death and the third most common cancer in the world. Depending on the origin of the mutation, colorectal carcinomas are classified as sporadic or hereditary. Cancers derived from mutations appearing during life, affecting individual cells and their descendants, are called sporadic and account for almost 95% of the CRCs. Less than 5% of CRC cases result from constitutional mutations conferring a very high risk of developing cancer. Screening for hereditary-related cancers is offered to individuals at risk for hereditary CRC, who have either not undergone genetic evaluation or have uncertain genetic test results. In this review, we briefly summarize the main findings on the correlation between sporadic CRC and the gut microbiota, and we specifically focus on the few evidences about the role that gut microorganisms have on the development of CRC hereditary syndromes. The characterization of a gut microbiota associated with an increased risk of developing CRC could have a profound impact for prevention purposes. We also discuss the potential role of the gut microbiota as therapeutic treatment.

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Gut Microbiome: A Promising Biomarker for Immunotherapy in Colorectal Cancer

Cited by 95 publications

References 72 publications

Potential Association between Vaginal Microbiota and Cervical Carcinogenesis in Korean Women: A Cohort Study

Potential Association between Vaginal Microbiota and Cervical Carcinogenesis in Korean Women: A Cohort Study

The Role of <b><i>Fusobacterium nucleatum</i></b> in Colorectal Carcinogenesis

Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer

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