Gut microbiota and obesity: Pathogenetic relationships and ways to normalize the intestinal microflora

Drapkina, О. М.; Корнеева, О. Н.

doi:10.17116/terarkh2016889135-142

Cited by 19 publications

(11 citation statements)

References 37 publications

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“…It is also found that the correction of the intestinal microbiota in patients with CVD improves the prognosis of the disease. Prescribing in the complex therapy preparations that increase the number of bacteria from genus Akkermansia , Bifidobacteria , Lactobacillus , Bacteroides , and Prevotella ameliorates the course of CVD [ 142 , 143 , 144 ]. It is known that bacteria from Bifidobacteria and Lactobacillus genus provide a local anti-inflammatory effect on the intestinal wall.…”

Section: The Neuroimmune Axis: Microbiota–intestine–brain-cvdmentioning

confidence: 99%

The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease

Suslov

Chairkina

Shepetovskaya

et al. 2021

JCM

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Currently, a bidirectional relationship between the gut microbiota and the nervous system, which is considered as microbiota-gut-brain axis, is being actively studied. This axis is believed to be a key mechanism in the formation of somatovisceral functions in the human body. The gut microbiota determines the level of activation of the hypothalamic–pituitary system. In particular, the intestinal microbiota is an important source of neuroimmune mediators in the pathogenesis of cardiovascular disease. This review reflects the current state of publications in PubMed and Scopus databases until December 2020 on the mechanisms of formation and participation of neuroimmune mediators associated with gut microbiota in the development of cardiovascular disease.

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Section: The Neuroimmune Axis: Microbiota–intestine–brain-cvdmentioning

confidence: 99%

The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease

Suslov

Chairkina

Shepetovskaya

et al. 2021

JCM

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“…[8,9]. Доказана взаимосвязь ожирения с состоянием кишечного микробиома [10,11]. В последние годы большой интерес исследователей вызывает изучение морфофункционального состояния желудка, а также особенностей качественного и количественного состава его микробиоты и их влияния на обменные нарушения.…”

Section: Motor-evacuation Disorders In Children With Obesity Recordedunclassified

Advantages of the application method for taking a biopsy of the gastric mucosa to assess its functional state and microflora composition in obese children

Кошурникова

Бокова

Терещенко

2021

jour

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Relevance. Obesity is one of the most pressing problems of modern Pediatrics.The purpose of the study: to study the morphofunctional state and features of the composition of the stomach microflora in obese children using and comparing various endoscopic methods of biomaterial sampling.Materials and methods. 164 children aged 7 to 17 years were examined. The main group — 85 obese people, the comparison group‑79 children with normal body weight and digestive diseases. Esophagogastroduodenoscopy was performed, followed by pathomorphological, bacterioscopic, and microbiological examination of the biological material. In addition to sampling the biopsy of the antral part of the stomach with a sterile farcept, 40 patients were additionally taken from the wall biological material by obtaining a smear from the mucous membrane with the author’s endoscopic probe.Research result. The frequency of inflammatory changes IN the gastrointestinal tract was high in both groups and did not depend on body weight. In the main group, duodeno-gastric reflux (DGR) (32–38% и 9–11%, p<0.05) and cardia insufficiency (46–54% и 36–46%, p>0.05) were more often diagnosed. With an increase in the degree of obesity, the total number of refluxes increased — from 45–53% at grade I to 64–75% at grade IV, and DGR — from 12–14% to 49–58%, respectively. The most frequent localization of inflammatory changes in children of the main group was the antral (43–50%), less often — the stomach body (26–30%), while in the comparison group the body was more often affected (42–52%) and less often the antral (24–30%). In most children, regardless of the group (56–66% и 51–65%), chronic gastritis of moderate activity was registered. A high degree was significantly more often detected in the comparison group (14–16% and 24–30%, p<0.05), while a weak degree was detected in children of the main group (16–19% and 5–6%, p<0.05). In children of the main group, H. pylori (HP) was more often detected (45–53% и 25–32%, p <0.05), while 1 degree of contamination was more often determined (43–51% и 39–48%), while in the comparison group — 3 degree (15–18% и 24–30%). With increasing degree of obesity increased frequency of contamination from the antrum, HP — from 36–42% when I level up to 60–71% in IV degree of obesity. When using the application in HP+ children of the main group were more often sown opportunistic pathogens in a more diverse species composition and a more pronounced decrease in planting indigenous microflora, and regardless of HP significantly more prevalent growth of E. coli and Candida. In the presence of DGR, independently of the group, a significantly higher growth of fecal flora and a more pronounced decrease in the seeding of indigenous microflora was obtained.Conclusions.1. A high frequency of inflammatory and functional disorders in children, regardless of body weight, was established.2. Motor-evacuation disorders in children with obesity recorded often (63% and 43%). As the degree of obesity increases, their frequency increases. DGR in obese children is recorded significantly more often (38% and 11%, p<0.05).3. Children with obesity have a higher frequency of registering a low degree of activity of chronic gastritis, and children with normal body weight have a high frequency. The degree of activity of the inflammatory process does not depend on the degree of obesity and the duration of the disease.4. HP in obese children is detected 1.5 times more often than in children with normal body weight; the predominance of low (1 degree) contamination is characteristic. With an increase in the degree of obesity, the frequency of HP contamination increases (from 42% at grade I to 70% at grade IV obesity).5. HP-positive children show significantly higher growth of E. Faecium, S. viridans and Streptococcus faecalis and lower seeding of Lactobacterium and Bifidobacterium.6. DGR contributes to a more pronounced decrease in the growth of indigenous microflora, only Streptoco

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“…On the other hand, they were described as an important determinant of energetic metabolism and obesity. (60) The GM are responsible for the fermentation of undigested proteins and carbohydrates, utilization of hydrogen, and transformation of bile acids, gases, and secondary bile acids. Metabolic functions of the GM can contribute to disturbances of the intestine's immune function, chronic lowgrade inflammation, increased colonic permeability, motility disturbances, and visceral hypersensitivity.…”

Section: Obesity and Fbds In Children: Possible Mechanisms Of Associamentioning

confidence: 99%

Functional Bowel Disorders and Obesity in Children: State of the Problem

Погодина¹,

Romanitsa²,

Рычкова³

2020

IJBM

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Obesity and functional bowel disorders (FBDs) are often observed in children and have common risk factors. The present review aimed to summarize the published data on the association between obesity and FBDs in children and a discussion of possible pathophysiological mechanisms that may be involved. Published data indicates that obesity and FBDs could be associated conditions. There is substantial evidence that obesity in children is associated with constipation. However, it should be noted that there were few studies in this direction, and those studies were heterogeneous in both the composition of participants and studied diagnostic criteria, and in the majority of cases, they were not adjusted for potential confounders. The association between obesity and FBDs can be explored through diet, peculiarities of eating behavior, and psychological factors. The most promising direction in the study could be the study of the GM, the changes in which can contribute to the development of immune dysfunctions of the bowel, chronic low-grade inflammation, increased colonic permeability, motility disturbances, and visceral hypersensitivity. The studies in this area can provide important data for developing a strategy of treatment and prevention of both groups of diseases.

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Gut microbiota and obesity: Pathogenetic relationships and ways to normalize the intestinal microflora

Cited by 19 publications

References 37 publications

The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease

The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease

Advantages of the application method for taking a biopsy of the gastric mucosa to assess its functional state and microflora composition in obese children

Functional Bowel Disorders and Obesity in Children: State of the Problem

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