Gut Microbiota Associated with Gestational Health Conditions in a Sample of Mexican Women

Benítez-Guerrero, Tizziani; Vélez-Ixta, Juan Manuel; Juárez-Castelán, Carmen Josefina; Corona-Cervantes, Karina; Piña-Escobedo, Alberto; Martínez-Corona, Helga; Sales-Millán, Amapola De; Cruz‐Narváez, Yair; Gómez-Cruz, Carlos Yamel; Ramírez-Lozada, Tito; Acosta-Altamirano, Gustavo; Sierra-Martínez, Mónica; Zárate-Segura, Paola; García-Mena, Jaime

doi:10.3390/nu14224818

Cited by 4 publications

(1 citation statement)

References 69 publications

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“…Significant differences in Bacteroides_caccae, Prevotella_ copri, and Bacteroides_cellulosilyticus between healthy individuals and GDM patients have been reported to be associated with GDM (Sweeting et al 2022). A previous study of a sample of Mexican women found a high abundance of Fusobacterium in the pregnancy health condition, followed by Eubacterium and Bacteroides (Benitez-Guerrero et al 2022). Multi-strain probiotics can regulate gut dysbiosis and improve metabolic and inflammatory outcomes in women with gestational diabetes mellitus (GDM) (Hasain et al 2022).…”

Section: Discussionmentioning

confidence: 99%

Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus

Liang,

Feng,

Yang

et al. 2023

Mol Med

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Background Children of mothers with gestational diabetes mellitus (GDM) are more prone to acquire type 2 diabetes and obesity as adults. Due to this link, early intervention strategies that alter the gut microbiome may benefit the mother and kid long-term. This work uses metagenomic and transcriptome sequencing to investigate how probiotics affect gut microbiota dysbiosis and inflammation in GDM. Methods GDM and control metagenomic sequencing data were obtained from the SRA database. This metagenomic data helped us understand gut microbiota abundance and function. KEGG detected and extracted functional pathway genes. Transcriptome sequencing data evaluated GDM-related gene expression. Finally, GDM animal models were given probiotics orally to evaluate inflammatory response, regulatory immune cell fractions, and leptin protein levels. Results GDM patients had more Fusobacteria and Firmicutes, while healthy people had more Bacteroidetes. Gut microbiota composition may affect GDM by altering the L-aspartate and L-asparagine super pathways. Mannan degradation and the super pathway of L-aspartate and L-asparagine synthesis enhanced in GDM mice with leptin protein overexpression. Oral probiotics prevent GDM by lowering leptin. Oral probiotics increased Treg, Tfr, and Breg cells, which decreased TNF-α and IL-6 and increased TGF-β and IL-10, preventing inflammation and preserving mouse pregnancy. Conclusion Dysbiosis of the gut microbiota may increase leptin expression and cause GDM. Oral probiotics enhance Treg, Tfr, and Breg cells, which limit the inflammatory response and assist mice in sustaining normal pregnancy. Thus, oral probiotics may prevent GDM, enabling targeted gut microbiota modulation and maternal and fetal health.

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Section: Discussionmentioning

confidence: 99%

Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus

Liang,

Feng,

Yang

et al. 2023

Mol Med

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Short-Chain Fatty Acids and Preeclampsia: A Scoping Review

Zhao,

Chen,

Liu

et al. 2024

Nutrition Reviews

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Background Preeclampsia (PE) is a pregnancy-associated hypertension disorder with high morbidity and mortality. Short-chain fatty acids (SCFAs)—molecules produced by gut microbes—have been associated with hypertension, yet their relation to PE remains uncertain. Objectives The aim was to review existing human studies that examined associations of the major SCFAs (acetate, propionate, butyrate) in pregnancy with PE development. Methods Two reviewers independently searched online databases (EMBASE, PubMed, Web of Science, and Cochrane Database of Systematic Reviews) in January 2024 using the following terms: “short-chain fatty acids,” “acetic acid,” “butyric acid,” “propionic acid,” and “preeclampsia.” The final set of included studies had to report associations of SCFAs with PE, be peer-reviewed, be written in English, and be conducted in humans. Results The abstracts of 907 studies were screened; 43 underwent full-text screening and 11 (1318 total participants, 352 with PE) were included in the final review. All studies used a case-control design. SCFAs were measured in a range of biospecimens (eg, serum, plasma, feces, placentas, and amniotic fluid) that were collected at distinct time points in pregnancy. All 7 studies that investigated butyrate found that it was lower in PE cases than in controls, with 6 of these showing statistical significance (P < .05). Five studies showed that acetate was significantly lower in individuals with PE compared with healthy individuals, while 1 study found that acetate was significantly higher in PE cases. One study reported significantly higher propionate among PE cases vs controls, while 2 studies reported significantly lower propionate levels in PE cases. The nuance in results for acetate and propionate may owe to reasons such as differences in distributions of population characteristics associated with SCFA level and PE or type of PE (early vs late). Conclusion Current epidemiologic evidence, which derives only from case-control studies, suggests that SCFAs, particularly butyrate (protective), in pregnancy are related to the development of PE. Large-cohort studies are warranted to investigate the temporality and potential causality of these associations.

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Scoping Review of Microbiota Dysbiosis and Risk of Preeclampsia

Jordan,

Amabebe,

Khanipov

et al. 2024

American J Rep Immunol

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Limited studies have investigated the role of the microbiota in hypertensive disorders of pregnancy (HDP), particularly preeclampsia, which often results in preterm birth. We evaluated 23 studies that explored the relationship between gut, vaginal, oral, or placental microbiotas and HDP. Scopus, ProQuest Health Research Premium Collection, ProQuest Nursing & Allied Health Database, EBSCO, and Ovid were searched for relevant literature. Majority (18) of studies focused on the gut microbiota, and far fewer examined the oral cavity (3), vagina (3), and placenta (1). One study examined the gut, oral, and vaginal microbiotas. The consensus highlights a potential role for microbiota dysbiosis in preeclampsia and HDP. Especially in the third trimester, preeclampsia is associated with gut dysbiosis—deficient in beneficial species of Akkermansia, Bifidobacterium, and Coprococcus but enriched with pathogenic Campylobacterota and Candidatus Saccharibacteria, with low community α‐diversity. Similarly, the preeclamptic vaginal and oral microbiotas are enriched with bacterial vaginosis and periodontal disease‐associated species, respectively. The trend is also observed in the placenta, which is colonized by gastrointestinal, respiratory tract, and periodontitis‐related pathogens. Consequently, a chronic proinflammatory state that adversely impacts placentation is implicated. These observations however require more mechanistic studies to establish the timing of the preceding immune dysfunction and any causality.

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Gut Microbiota Associated with Gestational Health Conditions in a Sample of Mexican Women

Cited by 4 publications

References 69 publications

Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus

Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus

Short-Chain Fatty Acids and Preeclampsia: A Scoping Review

Scoping Review of Microbiota Dysbiosis and Risk of Preeclampsia

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