Gut Microbiota Changes in Patients with Bipolar Depression

Hu, Shaohua; Li, Ang; Huang, Tingting; Lai, Jianbo; Li, Jingjing; Sublette, M. Elizabeth; Lü, Haifeng; Lu, Qing‐Yi; Du, Yanli; Hu, Zhiying; Ng, Chee H.; Zhang, Hua; Lu, Joan; Mou, Tingting; Lu, Shengyong; Wang, Dandan; Duan, Jinfeng; Hu, Jianbo; Huang, Manli; Wei, Ning; Zhou, Weihua; Ruan, Lifang; Li, Ming D.; Xu, Yi

doi:10.1002/advs.201900752

Cited by 120 publications

(185 citation statements)

References 67 publications

(96 reference statements)

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“…In terms of BD, previous studies found that BD was mainly associated with disturbances of Firmicutes and Bacteroidetes phyla . Consistent with this finding, we found that Firmicutes, Bacteroidetes, and Proteobacteria phyla were altered in BD relative to HC.…”

Section: Discussionsupporting

confidence: 90%

“…Herein, we found that the indices of α‐diversity (Ace and Chao) were decreased in BD relative to HC. Supporting this finding, lower gut microbial indices of α‐diversity (Chao and Obs) were also observed in a previous smaller sample size study of just BD versus HC . Moreover, both this current and our previous studies found no α‐diversity differences between MDD and HC.…”

Section: Discussionsupporting

confidence: 90%

“…Each participant signed an informed consent, and the fecal samples were collected in the two research centers. Diagnosis of MDD and BD was performed based on Structured Clinical Interview for DSM‐IV criteria by two senior psychiatrists as in the previous studies . Here, all the patients with MDD were undergone depressive episodes (abbreviated as MDD).…”

Section: Methodsmentioning

confidence: 99%

“…Recent emerging evidence showed major shifts in the gut microbial composition of patients with MDD or BD, in small medication‐free cohorts . For example, these studies showed that patients with MDD were characterized by enriched Enterobacteriaceae and Alistipes , and depleted Faecalibacterium , Coprococcus , and Dialister , relative to healthy control (HCs) .…”

Section: Introductionmentioning

confidence: 99%

“…For example, these studies showed that patients with MDD were characterized by enriched Enterobacteriaceae and Alistipes , and depleted Faecalibacterium , Coprococcus , and Dialister , relative to healthy control (HCs) . Furthermore, our previous studies have demonstrated that gut microbiome dysbiosis may contribute to depressive‐like behaviors . However, thus far, no studies have directly compared the microbial compositions of MDD and BD.…”

Section: Introductionmentioning

confidence: 99%

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Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression

et al. 2020

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Discriminating depressive episodes of bipolar disorder (BD) from major depressive disorder (MDD) is a major clinical challenge. Recently, gut microbiome alterations are implicated in these two mood disorders; however, little is known about the shared and distinct microbial characteristics in MDD versus BD. Here, using 16S ribosomal RNA (rRNA) gene sequencing, the microbial compositions of 165 subjects with MDD are compared with 217 BD, and 217 healthy controls (HCs). It is found that the microbial compositions are different between the three groups. Compared to HCs, MDD is characterized by altered covarying operational taxonomic units (OTUs) assigned to the Bacteroidaceae family, and BD shows disturbed covarying OTUs belonging to Lachnospiraceae, Prevotellaceae, and Ruminococcaceae families. Furthermore, a signature of 26 OTUs is identified that can distinguish patients with MDD from those with BD or HCs, with area under the curve (AUC) values ranging from 0.961 to 0.986 in discovery sets, and 0.702 to 0.741 in validation sets. Moreover, 4 of 26 microbial markers correlate with disease severity in MDD or BD. Together, distinct gut microbial compositions are identified in MDD compared to BD and HCs, and a novel marker panel is provided for distinguishing MDD from BD based on gut microbiome signatures.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression

et al. 2020

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Perturbations in Gut Microbiota Composition in Psychiatric Disorders

et al. 2021

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A systematic review on gut–brain axis aberrations in bipolar disorder and methods of balancing the gut microbiota

Ebiai

Gibson²,

Hernandez³

et al. 2023

Brain and Behavior

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Background: Bipolar disorder (BD) is a mood disorder that affects millions worldwide.Up to half of the diagnosed patients are reported to not receive adequate treatment.This study aims to assess the relationship between the gut-brain axis and BD and to discuss and compare the efficacy of varying methods of balancing gut microbiotas in BD.Methods: Using PubMed, Embase, and Google Scholar from November 2021 to February 2022, we found 5310 studies on gut microbiota and its relation to BD. Using our inclusion criteria, 5283 studies were excluded. A total of 27 full-text articles were assessed for eligibility. Also, 12 articles that met our criteria and eligibility criteria reported on 613 BD patients.Results: Most studies analyzed found an overall difference in gut microbiota composition in bipolar patients compared to healthy controls, though the alterations found were not consistent. Differences in Lactobacillus, Faecalibacterium, and Ruminococcus abundance in BD compared to controls were found to be the most consistent across a few of the studies, but their effects on the gut-brain axis conflicted. Probiotic supplementation was found to lower patient rehospitalizations and significantly improve depressive symptoms and cognitive impairments among patients with BD. Conclusions:Multiple studies included in this review point toward a possible link between BD and the gut microbiota. Probiotic supplements and other gut-balancing therapies could serve as effective adjunctive methods for the treatment of BD. Notable limitations of the studies included for analysis were small sample sizes and majority observational study designs. Furthermore, the microbiota aberrations found in patients with BD were not consistent across multiple studies. Despite these limitations, our findings demonstrate the need for further research regarding the relationship between aberrant gut microbiota profiles and BD, as well as the effectiveness of gut balancing methods as adjunctive treatments.

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Gut Microbiota Changes in Patients with Bipolar Depression

Cited by 120 publications

References 67 publications

Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression

Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression

Perturbations in Gut Microbiota Composition in Psychiatric Disorders

A systematic review on gut–brain axis aberrations in bipolar disorder and methods of balancing the gut microbiota

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