Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study

Hacıoğlu, Ayşa; Gündoğdu, Aycan; Nalbantoğlu, Ufuk; Karaca, Züleyha; Urhan, Muhammed Emre; Şahin, Serdar; Dokmetas, Hatice Sebile; Kadıoğlu, Pınar; Keleştimur, Fahrettin

doi:10.1007/s11102-021-01137-4

Cited by 13 publications

(13 citation statements)

References 51 publications

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“…26 These studies revealed that the blood microbiota could be translocated from the gastrointestinal tract (GIT) because most of the bacteria, as mentioned earlier at the phylum level, have been reported in the gut in several previous studies. 27,28 According to recent studies, microbial DNA is mainly found in cellular components in healthy people 25 ; there was a significant difference between the healthy gut and the blood microbial community composition. Firmicutes and Bacteroidetes phyla were predominant in the gut, while Proteobacteria was found dominant in the blood.…”

Section: He Althy Human B Lood Microb Iotamentioning

confidence: 99%

Exploring blood microbial communities and their influence on human cardiovascular disease

Khan

Zhou

et al. 2022

Clinical Laboratory Analysis

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Background Cardiovascular disease (CVD) is the single biggest contributor to global mortality. CVD encompasses multiple disorders, including atherosclerosis, hypertension, platelet hyperactivity, stroke, hyperlipidemia, and heart failure. In addition to traditional risk factors, the circulating microbiome or the blood microbiome has been analyzed recently in chronic inflammatory diseases, including CVD in humans. Methods For this review, all relevant original research studies were assessed by searching in electronic databases, including PubMed, Google Scholar, and Web of Science, by using relevant keywords. Results This review demonstrated that elevated markers of systemic bacterial exposure are associated with noncommunicable diseases, including CVD. Studies have shown that the bacterial DNA sequence found in healthy blood belongs mainly to the Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria phyla. In cardiac events, such as stroke, coronary heart disease, and myocardial infarction, the increased proportion of Proteobacteria and Actinobacteria phyla was found. Lipopolysaccharides are a major component of Proteobacteria, which play a key role in the onset of CVD. Moreover, recently, a study reported the lower cholesterol‐degrading bacteria, including Caulobacterales order and Caulobacteraceae family were both considerably reduced in myocardial infarction. Conclusion Proteobacteria and Actinobacteria were shown to be independent markers of the risk of CVD. This finding is evidence for the new concept of the role played by blood microbiota dysbiosis in CVD. However, the association between blood microbiota and CVD is still inconsistent. Thus, more deep investigations are required in future to fully understand the role of the bacteria community in causing and preventing CVD.

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Section: He Althy Human B Lood Microb Iotamentioning

confidence: 99%

Exploring blood microbial communities and their influence on human cardiovascular disease

Khan

Zhou

et al. 2022

Clinical Laboratory Analysis

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“…High diversity in microbiota may protect the host against diseases ( 51 , 52 ), and on the contrary, decreased diversity has been associated with various pathological conditions such as diabetes, dyslipidemia, obesity, and hypertension ( 32 , 44 , 53 ). A previous study including 7 patients with acromegaly observed a significantly less diverse microbiota in the patients than in controls by 16S rRNA amplicon sequencing ( 29 ). In our study, we confirmed the remarkably decreased diversity of microbiota in the patients compared to that in healthy controls, consistent with the prior study ( 29 ).…”

Section: Discussionmentioning

confidence: 94%

“…A previous study including 7 patients with acromegaly observed a significantly less diverse microbiota in the patients than in controls by 16S rRNA amplicon sequencing ( 29 ). In our study, we confirmed the remarkably decreased diversity of microbiota in the patients compared to that in healthy controls, consistent with the prior study ( 29 ). Also, Hacioglu et al demonstrated the increased abundance of phylum Bacteroidetes along with a decreased Firmicutes/Bacteroidetes ratio in the same study, and we found similar results in our study, strengthening its role as a characteristic change (Fig.…”

Section: Discussionmentioning

confidence: 94%

“…Here, our results show a significantly altered microbial composition in patients with GH-secreting pituitary adenoma (GHPA). Compared to an earlier study investigating microbiota in GHPA patients using 16S-based techniques, the chosen methods allowed for the detection of changes at the species level ( 29 ). We confirmed a decreased diversity of microbiota in the patients compared with that in healthy controls and found increased levels of Oscillibacter and Enterobacter genera in GHPA and uncovered a strong association of Enterobacter with GH/IGF-1 axis in the disease.…”

Section: Discussionmentioning

confidence: 99%

“…As a rare endocrinopathy, GHPA results in somatic overgrowth, i.e., acromegaly, and multiple systemic comorbidities, including diabetes, hypertension, and increased risk of colonic polyps and cancer ( 22 – 28 ). The latest research from Hacioglu et al preliminary uncovered the altered composition of gut microbiota in seven patients with newly diagnosed acromegaly through 16S-based techniques ( 29 ). However, both a larger cohort and in-depth investigation are needed to unveil the causative relationship between acromegaly and microbial alteration.…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of Gut Microbiota in Patients with GH-Secreting Pituitary Adenoma

et al. 2022

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Circulating microbiota and metabolites: Insights into cardiovascular diseases

Khan

Usman

et al. 2022

Clinical Laboratory Analysis

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Background:In almost every country, cardiovascular diseases are the major cause of death, which are responsible for 17.7 million deaths worldwide, or 54% of all deaths.However, the latest evidence has shown that non-communicable diseases such as obesity, diabetes, and cardiovascular events are significantly influenced by the blood microbiota and circulating metabolites. Methods:We searched online databases for the most recent related papers through the comprehensive international databases of the Institute of PubMed/ MEDLINE, ISI/WOS, and Scopus up to August 2022, using MESH terms and the related keywords in the English language. Considering the titles and abstracts, unrelated studies were excluded. The full texts of the remained studies were evaluated by authors, independently. Then, the studies' findings were assessed and reported. Results:The study demonstrated that the bacterial profiles of patients with cardiovascular diseases and healthy individuals are significantly different. The diseased patients showed a significantly high abundance of phylum Proteobacteria, an important Proteobacterial component known as lipopolysaccharides that has been linked to the pathogenesis of cardiovascular disease, while phylum Firmicutes were found in healthy individuals. It suggests that Proteobacteria has a direct role in the onset of cardiovascular disease. Conclusion:We focused on the blood bacterial composition and circulating microbial metabolites in their relationship with the etiology and onset of cardiovascular disease. However, the various genera and species in the results reported were not always identical. Therefore, the microbial community structure of blood was more complicated and thus required a more in-depth exploration.

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Gut microbiota in patients with newly diagnosed acromegaly: a pilot cross-sectional study

Cited by 13 publications

References 51 publications

Exploring blood microbial communities and their influence on human cardiovascular disease

Exploring blood microbial communities and their influence on human cardiovascular disease

Characteristics of Gut Microbiota in Patients with GH-Secreting Pituitary Adenoma

Circulating microbiota and metabolites: Insights into cardiovascular diseases

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