Gynura procumbens modulates the microtubules integrity and enhances distinct mechanism on doxorubicin and 5-flurouracil-induced breast cancer cell death

Nurulita, Nunuk Aries; Meiyanto, Edy; Sugiyanto, .; Matsuda, Eishou; Kawaichi, Masashi

doi:10.1007/s13596-012-0063-5

Cited by 12 publications

(7 citation statements)

References 26 publications

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“…The ethyl acetate extract enhanced the anti-proliferative effect of doxorubicin and 5-flurouracil in MCF-7 and T47D breast cell lines. In MCF-7 cells, the combination therapy induced c-PARP mediated apoptosis leading to cell death (Nurulita et al, 2012). One study reported the cytotoxic properties of protein fractions against MDA-MB-231 breast cancer cells (Hew et al, 2013).…”

Section: G Procumbensmentioning

confidence: 99%

See 1 more Smart Citation

Ethnomedicinal uses, phytochemistry, and biological activities of plants of the genus Gynura

Bari

Khandokar

Haque

et al. 2021

Journal of Ethnopharmacology

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Section: G Procumbensmentioning

confidence: 99%

“…Merr. ( Davies, 1980aDavies, , 1980bDavies, , 1979Nurulita et al, 2012;Perry and Metzger, 1980;Vanijajiva, 2009) 45 ( Davies, 1980aDavies, , 1980bDavies, , 1979Nurulita et al, 2012;Siriwatanametanon and Heinrich, 2011;Vanijajiva, 2009) (…”

Section: Malaysia and Thailandmentioning

confidence: 99%

Ethnomedicinal uses, phytochemistry, and biological activities of plants of the genus Gynura

Bari

Khandokar

Haque

et al. 2021

Journal of Ethnopharmacology

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“…In view of this, co-treatment studies of G. procumbens and chemotherapy drugs have been carried out. The combination of G. procumbens extract with doxorubicin or 5-fluorouracil resulted in strong synergistic effect against breast and colon cancer cells (Meiyanto and Jenie, 2007; Nurulita et al, 2011, 2012). However, co-treatment of G. procumbens with cisplatin appeared to be antagonistic as this combination failed to further suppress cancer cell proliferation (Nurulita et al, 2011).…”

Section: Biological Activitiesmentioning

confidence: 99%

Gynura procumbens: An Overview of the Biological Activities

et al. 2016

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Gynura procumbens (Lour.) Merr. (Family Asteraceae) is a medicinal plant commonly found in tropical Asia countries such as China, Thailand, Indonesia, Malaysia, and Vietnam. Traditionally, it is widely used in many different countries for the treatment of a wide variety of health ailments such as kidney discomfort, rheumatism, diabetes mellitus, constipation, and hypertension. Based on the traditional uses of G. procumbens, it seems to possess high therapeutic potential for treatment of various diseases making it a target for pharmacological studies aiming to validate and provide scientific evidence for the traditional claims of its efficacy. Although there has been considerable progress in the research on G. procumbens, to date there is no review paper gathering the reported biological activities of G. procumbens. Hence, this review aims to provide an overview of the biological activities of G. procumbens based on reported in vitro and in vivo studies. In brief, G. procumbens has been reported to exhibit antihypertensive, cardioprotective, antihyperglycemic, fertility enhancement, anticancer, antimicrobial, antioxidant, organ protective, and antiinflammatory activity. The commercial applications of G. procumbens have also been summarized in this paper based on existing patents. The data compiled illustrate that G. procumbens is a potential natural source of compounds with various pharmacological actions which can be utilized for the development of novel therapeutic agents.

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“…Cotreatment studies of G. procumbens and chemotherapy drugs also have been carried and reported good results. In an experiment, cotreatment of G. procumbens with other drugs such as doxorubicin or 5-fluorouracil lead to strong synergistic effect against breast and colon cancer cells [33][34][35]. However, in other cases, it showed an antagonistic effect when cotreatment of G. procumbens extract with cisplatin and failed to further suppress cancer cell proliferation [36].…”

Section: Anticancermentioning

confidence: 99%

An Updated Phytochemical and Pharmacological Review on Gynura Procumbens

Ashraf

2019

Asian J Pharm Clin Res

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Nowadays, the use of medicinal plants increased significantly for the aim of producing more effective drugs with fewer side effects. Gynura procumbens (family Asteraceae) is a high value medicinal plant with different properties that are considered less, regardless of having great therapeutic potential in traditional medicine. Many pharmacological studies have established the ability of this plant to exhibit antimicrobial, antioxidant, hepatoprotection, antigenotoxic, antiplasmodial, cytotoxic, cardioactive, antidiabetic, anti-inflammatory, etc. The aim of this study was to review the updated phytochemical, pharmacological investigations as well as the traditional and therapeutic uses of G. procumbens. Important and different experimental data have been addressed along with a review of most of the phytochemicals identified in this plant.

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Gynura procumbens modulates the microtubules integrity and enhances distinct mechanism on doxorubicin and 5-flurouracil-induced breast cancer cell death

Cited by 12 publications

References 26 publications

Ethnomedicinal uses, phytochemistry, and biological activities of plants of the genus Gynura

Ethnomedicinal uses, phytochemistry, and biological activities of plants of the genus Gynura

Gynura procumbens: An Overview of the Biological Activities

An Updated Phytochemical and Pharmacological Review on Gynura Procumbens

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