In tissue engineering, biocompatible porous scaffolds that try to mimic the features and function of the bone are of great relevance. In this paper, an effective method for the design of 3D porous scaffolds is applied to the modelling of structures with variable architectures. These structures are of interest since they are more similar to the stochastic configuration of real bone with respect to architectures made of a unit cell replicated in three orthogonal directions, which are usually considered for this kind of applications. This property configures them as, potentially, more suitable to satisfy simultaneously the biological requirements and those relative to the mechanical strength. The procedure implemented is based on the implicit surface modelling method and the use of a triply periodic minimal surface (TPMS), specifically, the Schwarz's Primitive (P) minimal surface, whose geometry was considered for the development of scaffolds with different configurations. The representative structures modelled were numerically analysed by means of finite element analysis (FEA), considering them made of a biocompatible titanium alloy. The architectures considered were thus assessed in terms of the relationship between the geometrical configuration and the mechanical response to compression loading. taken into account. Biodegradable polymeric materials have been considered [3] to facilitate cell ingrowth due to material resorption over time along with the adequate mechanical environment provided by the structure of the scaffold. For load bearing applications investigated in this study, biocompatible metallic scaffolds are expected to fulfill the required mechanical strength. In particular, the use of titanium and its alloys, such as Ti-6Al-4V, is well reported in literature [4-6] since they have an excellent strength-to-weight ratio, toughness, and most importantly, the biocompatibility and corrosion resistance of their naturally forming surface oxide [7], making them particularly suitable for these applications.The advent of new manufacturing technologies, such as additive manufacturing (AM), has expanded the potentiality in the design of these structures since with these techniques, tailored design specification implants and highly complex and custom-fitting medical devices can be provided [8].The modelling of these structures can be conducted with different approaches. The simpler approach uses parametric Computer-Aided Design (CAD) modelling in which a unit cell is generated from solid features that are combined together. A three-dimensional (3D) periodic array of the unit cell can be carried out along three mutually perpendicular directions to obtain the final architecture. Usually, lattice-based geometries [5,6,9] such as cubic, diamond lattice, rhombic dodecahedron, or similar, are generated with this method since more complex geometries are difficult to model.Another approach, which was used in this paper, is the method of implicit surface modelling (ISM). ISM is a highly flexible approach for the generation ...