Haemato-biochemical Changes Following Administration of Propofol in Combination with Buprenorphine in Atropinized Dogs

Alternations on haemato-biochemical profiles following administration of atropine-buprenorphine-propofol anaesthesia in goats

“…The values of serum urea nitrogen and serum creatinine showed nonsignificant transient increase at 60 minutes following administration of atropine-buprenorphine-propofol anaesthesia and these values tend to return towards the base level by end of observation. Similar observations were reported by Anandmay et al (2016) [2] with propofolbuprenorphine in atropinized dogs. The non-significant alternation in creatinine and blood urea nitrogen values might be due to increased level of antidiuretic hormone (ADH) alongwith decreased glomerular filtration as emphasized by Lobetti and Lambrechts (2000) [10] and Suresha et al, (2012) [18] during anaesthetic procedure in dogs.…”

“…Fall in Hb, PCV and TLC after propofol has also been reported by Kelawala et al (1991) [8] in goats and Singh et al (2014) [15] in buffalo calve. Anandmay et al (2016) [2] reported significant fall (P<0.05) in Hb, PCV and TEC at initial intervals of observation as compared to baseline whereas, TLC and DLC (neutrophils, eosinophil, lymphocyte and monocyte) varied non-significantly up to 24 hours of observation following administration of propofol in combination with buprenorphine in atropinized dog. [2] with propofolbuprenorphine in atropinized dogs.…”

“…Anandmay et al (2016) [2] reported significant fall (P<0.05) in Hb, PCV and TEC at initial intervals of observation as compared to baseline whereas, TLC and DLC (neutrophils, eosinophil, lymphocyte and monocyte) varied non-significantly up to 24 hours of observation following administration of propofol in combination with buprenorphine in atropinized dog. [2] with propofolbuprenorphine in atropinized dogs. Similarly, Kumar et al (2010) [9] also reported hyperglycemia after administration of propofol premeditated with cannabis indica (Bhang) extract in dogs whereas, Pathak et al (2012) [12] reported nonsignificant variation in plasma glucose concentration after intraspinal administration of buprenorphine in buffalo calves.…”

“…Propofol should be combined with analgesic drugs as it is devoid of any substantial analgesic effects. In addition to the hypnotic agent, such as propofol, opioids are often used due to their synergistic hypnotic and analgesic properties (Anandmay et al, 2016) [2] . Pharmacodynamically, the interaction between propofol and opioids is generally found to be synergistic (Vuyk, 1997) [19] .…”

Comparative Evaluation of Haemato- Biochemical Profiles in Atropinized Dogs Premedicated with Pentazocine or Meperidine in Propofol Anaesthesia

“…Moreover, drug combinations typically reduce the dose of general anaesthesia or other anaesthetic which may be beneficial in certain situations (Smischney et al, 2012). Various workers have studied the changes in haemato-biochemical parameters following administration of xylazine and propofol (Dewangan et al, 2016), buprenorphine and propofol (Anandmay et al, 2016). There is lack of data related to biochemical profiles with the meperidiine, and pentazocine as opioids in combination with propofol.…”