Haemato-biochemical studies on triflupromazine HCL and diazepam premedication for propofol anaesthesia in dogs

Abstract

Aim: To study the effect of Triflupromazine Hcl and diazepam in combination with propofol as preanaesthetic on haematobiochemical parameters in dogs was carried out. Materials and Methods: 16 clinical cases of dogs undergoing different surgical interventions irrespective of age, sex and breed were allotted randomly in to two groups viz., Group A (Triflupromazine Hcl -propofol) and Group B (diazepampropofol) consisting eight dogs each. Blood samples were collected at different intervals from both the Groups in heparinised syringes as follows: Prior to premedication, fifteen minutes after premedication, fifteen minutes, one hour, six hour, 24 hour and 48 hour after induction with Propofol. The samples were subjected for various hematological and biochemical analysis. Results: Hematology revealed a significant (P 0.05) fall in total erythrocyte count (TEC), packed cell volume (PCV) and haemoglobin (Hb), whereas TLC showed a non significant decrease in both the groups throughout the observation period of 48 hours. In the present study blood glucose level was significantly increased between 15 min to one hour in Group A and 15 min to 6 hours of observation period of the study in Group B. The total plasma protein (TPP), alanine amino transferase (ALT),alkaline phosphatase (AP) and creatinine levels did not differ significantly in both the groups throughout the observation period of 48 hours. Conclusion: Both the anaesthetic combinations were found to be safe and effective with smooth and stress free recovery. However triflupromazine Hcl premedication proved to be better with quick sedative effect, long duration of anaesthesia with less induction dose of propofol and shorter recovery time than diazepam.

Evaluation of some prescribed and over-the-counter drugs induced hemato-biochemical changes in mice

“…Likewise, Orinya et al (2016) reported that after administrating diclofenac decreased Hb content in wistar rats. Similar results have been observed in dogs following diazepam administration by Suresha et al (2012).…”

“…Likewise, Hossain et al (2003) reported that paracetamol significantly decreased TEC. Similar response has been reported by Suresha et al (2012) due to diazepam.…”

“…Mean blood glucose level before treatment was 4.12±0.13 and after treatment with diclofenac mean blood glucose level on 7 th , 14 th , 21 st and 28 th day were 4.86±0.22, 5.53±0.36, 6.05±0.48 and 6.71±0.66, respectively in group C. Mean blood glucose level before treatment was 4.51±0.31 and after treatment with pantoprazole mean blood glucose level on 7 th , 14 th , 21 st and 28 th day were 4.79±0.34, 5.66±0.53, 5.98±0.48 and 7.87±1.53, respectively in group D. Mean blood glucose level before treatment was 4.33±0.19 and after treatment with ranitidine mean blood glucose level on 7 th , 14 th , 21 st and 28 th day were 4.61±0.29, 5.41±0.10, 6.34±0.59 and 7.26±0.94, respectively in group E. Mean blood glucose level before treatment was 4.50±0.37 and after treatment with diazepam mean blood glucose level on 7 th , 14 th , 21 st and 28 th day were 4.66±0.38, 5.12±0.59, 5.88±0.43 and 6.59±0.76, respectively in group F. Mean blood glucose level before treatment was 5.41±0.67 and after treatment with clonazepam mean blood glucose level on 7 th , 14 th , 21 st and 28 th day were 5.58±0.73, 6.52±0.79, 7.39±0.83 and 7.53±1.10, respectively in group G. In confirmatory to the present findings, Hossain et al (2003) reported that paracetamol significantly increased blood glucose in mice. Similar response has been reported due to paracetamol (Amin et al, 2004), diclofenac (Ahmad et al, 2012), pantoprazole (Agrawal et al, 2018, ranitidine (Gentile et al, 1986), diazepam (Suresha et al, 2012) and clonazepam (Bougherara and Bouaziz, 2014). ±1.10** The above values represent the mean  standard deviation (SD) ** = Significant at 1 per cent level (p<0.01) * = Significant at 5 per cent level (p<0.05)…”

Evaluation of efficacy and safety of glycopyrrolate - xylazine - propofol anesthesia in buffalo calves

“…Very minimal effects on the hematological parameters have been reported after xylazine administration in healthy dogs [ 30 ]. No significant variation in Hb and PCV in buffalo calves have been observed during the entire period of observation after propofol administration [ 6 , 7 ] while significant falls in Hb and PCV have been reported throughout the observation period in dogs during triflupromazine or diazepam premedication with propofol anesthesia [ 11 ].…”

“…Propofol was found to be a safe injectable anaesthetic agent for induction of general anesthesia in buffalo calves, but transient apnoea was observed to be the most prevalent side effect [ 6 , 7 ]. Various pre-anesthetic combinations have been used with propofol; to prolong the duration of anesthesia along with shorter recovery time, thereby improving quality of anesthesia [ 8 - 11 ]. Xylazine is an alpha2-adrenergic receptor agonist with potent sedative, analgesic and muscle relaxant activity and was widely used in large animals for restraining [ 12 ].…”