Haematological features and differentiation of recurrent oral ulceration

Challacombe, Stephen; Barkhan, P.; Lehner, Thomas

doi:10.1016/0007-117x(77)90006-3

Cited by 67 publications

(48 citation statements)

References 28 publications

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“…Each patient was examined clinically with particular attention to any abnormal oral appearances. All patients underwent a routine haematological investigation (Challacombe et al, 1977) together with a serum ferritin, liver function tests, rheumatoid factor (rheumaton screening test), and ESR estimation. Ten patients consented to a labial gland biopsy.…”

Section: Methodsmentioning

confidence: 99%

Prevalence and intraoral distribution of Candida albicans in Sjögren's syndrome.

Tapper-Jones¹,

Aldred²,

Walker³

1980

J Clin Pathol

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An imprint culture technique has been employed to study the prevalence and intraoral distribution of Candida albicans in 16 patients with Sjögren's syndrome and in 16 healthy controls matched for age, sex, and dental status. The prevalence and intraoral density of C. albicans was found to be significantly higher at almost all sites in the Sjögren's patients than in the controls. The distribution of candida was also altered, being significantly higher in the floor of the mouth and anterior labial sulcus in the Sjögren's group. There was an approximate inverse relationship between candida populations and rate of salivary flow. Mean candida densities were found to be significantly higher in those Sjögren's patients with detectable serum rheumatoid factor in the serum. However, patients with primary Sjögren's syndrome had significantly higher mean candida densities compared with patients with secondary Sjögren's syndrome.

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Section: Methodsmentioning

confidence: 99%

Prevalence and intraoral distribution of Candida albicans in Sjögren's syndrome.

Tapper-Jones¹,

Aldred²,

Walker³

1980

J Clin Pathol

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“…In several studies, hematinic (iron, folic acid, or vitamin B 1 2) deficiencies have been demonstrated to be twice as common in RAS patients than in controls (Wray et al, 1975;Challacombe et al, 1977aChallacombe et al, , 1983Hutcheon et al, 1978;Tyldesley, 1983;Rogers and Hutton, 1986;Field et al, 1987;Porter et al, 1988). About 20% of patients with RAS may have a hematinic deficiency, though one US study did not report any hematinic problem (Olsen et al, 1982).…”

Section: Clinical Featuresmentioning

confidence: 99%

Recurrent Aphthous Stomatitis

Porter

Scully

Pedersen

1998

Critical Reviews in Oral Biology & Medicine

252

143

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“…Of these patients, 27%4 sufferered from major, minor or herpetiform aphthae at different times. The incidence and type of aphthae seen were similar in both the deficient and g non-deficient groups and did not differ from the e incidence reported elsewhere (Lehner, 1968; Chalc lacombe, Barkham and Lehner, 1977). Aetiology of deficiencies All patients were investigated to define the cause of the deficiency and the results are shown in Table 4.…”

Section: Clinical Examinationmentioning

confidence: 63%

Clinical and haematological screening in recurrent aphthae

Hutcheon

Dagg

Mason³

et al. 1978

Postgraduate Medical Journal

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Summary A series of 328 consecutive out-patients with recurrent aphthae were screened for deficiencies of iron, folic acid and vitamin B12, by examination of the peripheral blood, by assays of serum vitamin B12 and corrected whole blood folate, and estimation of the serum iron and total iron binding capacity; deficiencies were demonstrated in 45 patients (13·7%). Of these, 31 were deficient in iron, 15 in folic acid and 11 in vitamin B12; 11 patients had combined deficiencies. Of the 45 aphthae patients with deficiencies, 29 had anaemia or demonstrable abnormalities in the red cell indices or stained blood film, and the essay results were confirmatory. In the remaining 16 patients, no red cell changes were present, and diagnosis depended entirely on reduced levels of serum vitamin B12, whole blood folate or iron saturation of transferrin; such latent deficiencies occurred only with iron and folic acid, whereas all patients with vitamin B12 deficiency even without anaemia had morphological changes in the blood. Individual patients with a deficiency could not be distinguished from those without a deficiency on the basis of clinical examination of the mouth ulcers. However, aphthae patients who also had glossitis or angular cheilitis were more likely to suffer from such deficiencies. Thirty-nine of the deficient aphthae patients available for follow-up were assessed at least 6 months after appropriate replacement therapy; 23 showed a complete remission of ulcers, 11 were improved and 5 were not helped. It is suggested that the considerable incidence of deficiencies found in this series and the clinical and haematological response to replacement therapy confirms the need for full screening of patients with re-recurrent aphthae. Since 16 out of 45 of these patients had no anaemia or morphological abnormalities in the peripheral blood, their deficiencies would have been missed on routine haematological examination alone; for this reason it is recommended that screening should also include estimation of the serum iron and total iron-binding capacity, whole blood folate and, possibly vitamin B12.

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Haematological features and differentiation of recurrent oral ulceration

Cited by 67 publications

References 28 publications

Prevalence and intraoral distribution of Candida albicans in Sjögren's syndrome.

Prevalence and intraoral distribution of Candida albicans in Sjögren's syndrome.

Recurrent Aphthous Stomatitis

Clinical and haematological screening in recurrent aphthae

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