Haematological indices and bone marrow morphology in pancytopenia/bicytopenia

Dagdia, Kirti S; Deshmukh, Anil T; Soni, Ramawatar; Jane, Dilip S

doi:10.4103/1110-1067.178476

Egypt J Haematol

2016

DOI: 10.4103/1110-1067.178476

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Haematological indices and bone marrow morphology in pancytopenia/bicytopenia

Kirti S Dagdia

Anil T Deshmukh

Ramawatar Soni

et al.

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Cited by 4 publications

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Clinicohematological Profile of Patients with Bicytopenia

Murshed,

Bhat

2024

Journal of Health and Allied Sciences NU

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Background Bicytopenia (BC) is a reduction in counts in any of two cell lineages of blood, which can be a combination of anemia with thrombocytopenia, anemia with leukopenia, or leukopenia with thrombocytopenia. The etiology of BC can be a malignancy, nonmalignant disease, infectious cause, or drug-induced. Aim To assess the clinicohematological profile in patients with BC. Materials and Methods This prospective study was conducted in the hematology laboratory at the Justice K.S. Hegde Charitable Hospital. Patients with BC detected during the analysis of blood for any clinical condition were included in the study. Blood parameters assessed were hemoglobin, red blood cell count, total leukocyte count, and platelet count. Results In this study, 86 patients' samples with BC were collected, out of which 55.8% were male, and 44.2% were female. The most common BC was anemia with thrombocytopenia (69.8%). The most common etiology of BC was found to be nonmalignant (37.2%), followed by malignant (37.2%), infectious (25.6%), and drug-induced (4.7%) cases. Most of the patients with BC presented with fever, pallor, and generalized weakness. Conclusion Anemia with thrombocytopenia emerged as the predominant form of BC in the nonmalignant group, while the malignant etiology group presented with anemia with leukopenia. The infectious etiology group presented with leukopenia with thrombocytopenia. Neonatal sepsis emerged as the most prevalent cause of BC in the age group younger than 10 years, viral fever in the age group of 10 to 39 years, acute lymphoblastic leukemia in the age group of older than 70 years, and chronic liver disease in patients aged between 40 and 69 years.

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Clinicohematological Profile of Patients with Bicytopenia

Murshed,

Bhat

2024

Journal of Health and Allied Sciences NU

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Clinico-hematological evaluation of pancytopenic adults in a tertiary care institution

2020

IJPO

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Introduction:Pancytopenia is an important clinico-hematological entity encountered in our day-to-day clinical practice from a number of disease processes primarily and secondarily involving bone marrow. This study was carried out to evaluate bone marrow findings in patients with pancytopenia. Materials and Methods: This is a prospective cross sectional study carried out on 140 pancytopenia patients over the period of one and half years. Relevant clinical details were recorded, followed by screening of patients for routine blood investigations included a complete blood count, peripheral blood smear examination, reticulocyte count. Bone marrow aspiration was done in all cases and bone marrow biopsy performed whenever necessary and Perl's Prussian blue stain for grading of bone marrow iron stores were done in all cases. Data analysed was compared with various studies published in literature. Results: The maximum cases of pancytopenia were in the age group of 31 to 40 years with male preponderance. Dimorphic anemia (49.3%) was found to be the most common etiology of pancytopenia followed by megaloblastic anemia (35%), iron deficiency anemia (5.7%). We encountered two cases of non-Hodgkin's lymphoma and one case each of multiple myeloma, acute lymphoblastic leukemia, aplastic anemia and anemia of chronic disease. Most common clinical presentation was pallor followed by fatigue and fever. Conclusion: Present study concludes that basic primary hematological investigations along with bone marrow aspiration/trephine bone biopsy in the pancytopenia patients are helpful in understanding the disease process. This plays a key role in planning the further management.

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PANCYTOPENIA – CLINICAL & HAEMATOLOGICAL STUDY AT TERTIARY CARE CENTRE.

Dr¹,

Patil²,

Gogate³

et al. 2020

ijsr

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Introduction: Pancytopenia is the simultaneous presence of anaemia, leucopoenia and thrombocytopenia. This study was carried out to evaluate bone marrow findings in patients with pancytopenia. Materials and Methods: This is retrospective study carried out on 100 pancytopenia patient over the period of two years. Peripheral blood smears (PBS), Bone marrow aspiration (BMA) & Trephine Biopsy slides were retrieved from storage. Data analysed was compared with various studies published in literature Results: The maximum cases of pancytopenia were in the age group up to 20 years with male preponderance. Megaloblastic anaemia (43%) was found to be most common aetiology of pancytopenia and followed by iron deficiency anaemia (23%). Conclusion: Present study concludes that basic primary haematological investigations along bone marrow aspiration/trephine bone biopsy in the pancytopenia patients are helpful in understanding the disease process. This plays a key role in planning the further management.

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Haematological indices and bone marrow morphology in pancytopenia/bicytopenia

Cited by 4 publications

References 1 publication

Clinicohematological Profile of Patients with Bicytopenia

Clinicohematological Profile of Patients with Bicytopenia

Clinico-hematological evaluation of pancytopenic adults in a tertiary care institution

PANCYTOPENIA – CLINICAL & HAEMATOLOGICAL STUDY AT TERTIARY CARE CENTRE.

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