Haematological profiles in pure bred cattle naturally infected with Theileria annulata in Saudi Arabia

Omer, O. H.; Elmalik, Khitma Hassan; Mahmoud, O. M.; Haroun, E. M.; Hawas, A.; Sweeney, Diane; Magzoub, M.

doi:10.1016/s0304-4017(02)00094-8

Cited by 82 publications

(85 citation statements)

References 16 publications

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“…Haematological findings of the current study revealed significant decreases in total RBCs count, Hb concentration, PCV, PLT and PCT, which indicated severe anaemia, the same was reported by Omer et al (2002).The results also agreed with that of Sandhu et al (1998) who reported normocytic normochromic anaemia in cross-bred calves experimentally infected with T. annulata. The significant decrease in PCT (p \ 0.01) is attributed to the significant thrombocytopenia (p \ 0.01) (Schalm et al 1975), thrombocytopenia together with the normocytic normochrmic anaemia may indicate that anaemia may be partially attributed to depression of the bone marrow.…”

Section: Discussionsupporting

confidence: 82%

Studying the correlations among hematological and serum biochemical constituents in cattle theileriosis

Ellah

2013

J Parasit Dis

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The present study was undertaken to investigate the influence of tropical theileriosis on serum constituents, erythrocytes and platelets pictures and to study the correlation between the studied parameters. A total number of 26 cows were subjected to study. Out of them 16 cows were suffered from theileria infection. Comparing theileria infected group with the control group revealed significant decreases in total RBCS counts (p \ 0.01), haemoglobin concentration (p \ 0.01), packed cell volume (PCV) (p \ 0.01), platelets count (PLT) (p \ 0.01), plateletcrit (PCT) (p \ 0.01), significant decreases in serum total proteins (p \ 0.01), albumin (p \ 0.01), calcium (p \ 0.01), and phosphorus (p \ 0.01) levels, and significant increases in serum blood urea nitrogen (BUN) (p \ 0.05) and creatinine (p \ 0.05) levels, and in serum aspartate aminotransferase (p \ 0.01) and gamma glutamyl transferase (GGT) (p \ 0.01) activities. Correlations between serum biochemical parameters revealed significant positive correlations between total proteins and albumin (r = 0.598*), A/G ratio and albumin (r = 0.860**), calcium and albumin (r = 0.729*), calcium and A/G ratio (r = 0.752*), GGT and BUN (r = 0.539*), and significant negative correlations between A/G ratio and globulins (r = -0.809**) and between glucose and albumin (r = -0.614*). Erythrocytes count showed a significant negative correlation with mean corpuscular volume (MCV) (r = -0.966**) and red blood cells distribution width (RDW) (r = -0.909**). MCV showed a significant positive correlation with RDW (r = 0.860*) and PCV (r = 0.781*). RDW was positively correlated with PCV (r = 0.966**). PLT count showed a significant positive correlation with mean platelet volume (MPV) (r = 0.992**), platelets distribution width (PDW) (r = 0.956**) and PCT (r = 0.994**). Furthermore, MPV showed a significant positive correlation with PDW (r = 0.940**) and a negative correlation with PCT (r = -0.974**). PDW was negatively correlated with PCT (r = -0.974**). It could be concluded that theileria infection in cattle resulted in mia, thrombocytopenia, hypoproteinaemia, hypoalbuminaemia and hypophosphataemia, in addition to hepatic and kidney dysfunction.

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Section: Discussionsupporting

confidence: 82%

Studying the correlations among hematological and serum biochemical constituents in cattle theileriosis

Ellah

2013

J Parasit Dis

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“…Moreover, they were within normal range (Jain, 1993) indicating normocytic hypochromic anaemia (Table 1).However, the type of anaemia largely depends on the disease severity and accordingly various types of anaemia in babesiosis and theileriosis has been reported (Durrani et. al., 2006;Sharma et al, 2013, Mbassa et al, 1994Omer et al, 2002;Raminet al, 2011;Ganguly et al, 2015). In the present study, normocytic hypochromic anaemia observed in the B. bigamina infected crossbred cattle may be attributed to intravascular haemolysis of red blood cells (Pandy and Misra, 1987).…”

Section: Resultsmentioning

confidence: 88%

Direct blood PCR detection of Babesia bigemina and its effect on haematological and biochemical profile in crossbred cattle of eastern Haryana

Ganguly

Bisla

Ganguly

et al. 2017

IJAR

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The present study aimed to diagnose Babesia bigemina in naturally infected crossbred cows and to determine its effect on haemato-biochemical profile of host animals. Blood samples from lactating crossbred cows (n=30) between 3-6 years of age and showing clinical signs of babesiosis were collected, with or without anticoagulant, and analyzed for the protozoa by direct smear, direct blood PCR detection of the apical membrane antigen 1 (AMA-1) gene specific amplicon of B. bigemina and estimation of haematological and biochemical parameters. Healthy crossbred cows (n=10), examined free from haemoprotozoan infections were included as control. Blood Direct PCR revealed a 448-bp amplified fragment. Out of 150 random blood samples screened, (27/150) 18% were positive under light microscope, whereas direct blood PCR revealed (39/150) 26% samples positive for B. bigemina. The result shows higher specificity and sensitivity of PCR test over blood smear examination. The infected group showed significantly (p<0.001) decreased levels of TEC (3.04±0.19), Hb (4.78±0.27) and PCV (14.53 ±0.87) than healthy control animals. However, differences in the red blood cell indices (MCV, MCH and MCHC) were non-significant (p>0.05) between the groups indicating normocytic hypochromic anaemia in affected crossbred cattle. Serum samples of infected cows showed significantly (p<0.01) higher values of ALT (78.83±8.95), AST (146.13±7.62), BUN (27.09±1.02), creatinine (1.93±0.1) and TBIL (1.42±0.06) than that of healthy control. A significant decrease (p<0.01) of TSP (6.12±0.13) and albumin (2.39±0.09) was also recorded in the infected cows compare to healthy control. The standardized blood direct PCR method of the present investigation may be useful for rapid and reliable diagnosis of B. bigemina in conjunction with microscopic examination. Moreover, marked changes in haematological and serum biochemical profile observed in B. bigemina infected crossbred cows may be useful in understanding disease pathogenesis and undertaking necessary corrective measures.

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“…It can be caused by viral (BVDV, Bluetongue virus, Border disease virus), 46 rickettsial (Anaplasma phagocytophilum, 43,46 Ehrlichia ruminantium), protozoal (Theileria sp. ), 34,46 and fungal infections, as well as bone marrow disease, toxins, neoplasia, or idiosyncratic drug reactions. 27,48 Conditions commonly associated with eosinophilia include type I (immediate) 23,45 hypersensitivity reactions and parasitic infection.…”

Section: White Blood Cell Parameters and Their Interpretationmentioning

confidence: 99%

“…2,7,19,21,50 Microorganisms infecting ruminant RBCs include rickettsia (Anaplasma marginale), 1,20,26 protozoa (Babesia spp., Theileria spp., Trypanosoma spp., and Sarcocystis spp. ), 1,7,20,22,34,53 or bacteria (Mycoplasma wenyonii, Leptospira spp., and Clostridium spp.). 1,22,37 Further factors are copper deficiency or chronic copper intoxication, 22,30,50 hypophosphatemia (postparturient hemoglobinuria), 7,19,29 and water intoxication.…”

Section: Red Blood Cell Parameters and Their Interpretationmentioning

confidence: 99%

Hematology as a diagnostic tool in bovine medicine

2014

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Haematological profiles in pure bred cattle naturally infected with Theileria annulata in Saudi Arabia

Cited by 82 publications

References 16 publications

Studying the correlations among hematological and serum biochemical constituents in cattle theileriosis

Studying the correlations among hematological and serum biochemical constituents in cattle theileriosis

Direct blood PCR detection of Babesia bigemina and its effect on haematological and biochemical profile in crossbred cattle of eastern Haryana

Hematology as a diagnostic tool in bovine medicine

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