Haemorrhagic disease of the newborn in the British Isles: two year prospective study.

McNinch, A W; Tripp, J. H.

doi:10.1136/bmj.303.6810.1105

Cited by 169 publications

(150 citation statements)

References 10 publications

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“…10,12,23 Our present data confirm this observation, even upon analysis of a group of infants with an inherently higher risk of VKDB. A great benefit of this type of prophylaxis is that the prophylaxis does not depend on daily or weekly adherence to the advised administration or the still rather uncharacterized intestinal absorption of vitamin K in infants.…”

supporting

confidence: 80%

Prophylactic Dosing of Vitamin K to Prevent Bleeding

Witt¹,

Kvist²,

Jørgensen

et al. 2016

Pediatrics

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also, on behalf of the Netherlands Study group of Biliary Atresia Registry (NeSBAR) abstract BACKGROUND AND OBJECTIVES: Based on a high incidence of Vitamin K deficiency bleeding (VKDB) in breastfed infants with thus far unrecognized cholestasis, such as biliary atresia (BA), the Dutch regimen to prevent VKDB in breastfed infants was changed from a daily oral dosage of 25 μg to 150 μg vitamin K. Infants continued to receive 1 mg of vitamin K orally at birth. We compared the efficacy of the 150-μg regimen with the 25-μg regimen and with the Danish regimen of a single intramuscular (IM) dose of 2 mg vitamin K at birth.

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supporting

confidence: 80%

Prophylactic Dosing of Vitamin K to Prevent Bleeding

Witt¹,

Kvist²,

Jørgensen

et al. 2016

Pediatrics

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“…at birth) can prevent almost all cases o f late VKDB [10], Data from switch-over studies in one country [4], and from the simultaneous use of different prophylaxis strategies in three other countries [9,16,20] show that vitamin K prophylaxis with one oral dose (1-3 mg) is less effective than parenteral vitamin K. Re peated oral dose schedules have therefore been re commended. However, a recent publication from Germany suggests that even repeated oral vitamin K prophylaxis may not be as effective as the 1 mg dose administered i.m.…”

Section: Discussionmentioning

confidence: 99%

“…The data following the switch over in Australia confirm previous observations, that i.m. prophylaxis with 1 mg vitamin K can prevent almost all cases of late VKDB [4,9,10,16,19].…”

Section: Discussionmentioning

confidence: 99%

Prevention of vitamin K deficiency bleeding: efficacy of different multiple oral dose schedules of vitamin K

Cornelissen

Kries

Loughnan

et al. 1997

European Journal of Pediatrics

157

140

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There is consensus that late vitamin K defi ciency bleeding (VKDB) should be prevented by vitamin K prophylaxis, One single dose of 1 mg vitamin Ki is effective if given i.m. or s.c., but not if given orally. Repeated oral doses might be as effective as the par enteral dose but the optimal dose regimen remains to be established. Different oral dose schedules are presently used in different countries. In Australia, Germany, The Netherlands and Switzerland active surveillance data on late VKDB were collected in a similar manner and failure rates compared. Identical case definitions were used. There were three basic strategies for oral and one for parenteral vitamin K prophylaxis for healthy new borns in the four countries: (1) daily supplementation of low dose vitamin K (25 pig) for breast-fed infants (The Netherlands); (2) 3 x

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“…route is known to be effective in preventing both early haemorrhagic disease in neonates and late-onset bleeding in older babies (Dam et al, 1952;McNinch and Tripp, 1991;Zipursky, 1999). The efficacy of oral vitamin K is less certain as there is a recognised problem of absorption in some babies, and additional difficulties in compliance with multiple-dose oral regimens (Zipursky, 1999;Wariyar et al, 2000;von Kries et al, 2003).…”

mentioning

confidence: 99%

Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study

et al. 2003

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The relationship between neonatal vitamin K received by the intramuscular (i.m.) route and the development of leukaemia or other cancers was investigated as part of a national case -control study of childhood cancer, using data abstracted from obstetric and neonatal records. The analyses included 2530 children diagnosed with cancer before 15 years of age, 1174 of whom had leukaemia and 4487 control children without cancer. Overall, 39% of cases and 42% of controls had records of i.m. vitamin K administration, while 24% of cases and 22% of controls had no record of whether or not they had received vitamin K. Using subjects who received i.m. vitamin K as the baseline group, our analyses found no association between the administration of i.m. vitamin K and either leukaemia or other cancers as a group. We conclude that there is no convincing evidence that neonatal vitamin K administration, irrespective of the route by which it is given, influences the risk of children developing leukaemia or any other cancer.

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Haemorrhagic disease of the newborn in the British Isles: two year prospective study.

Abstract: Objective-To determine the incidence of haemorrhagic disease of the newborn in the British Isles, study risk factors, and examine the effect of vitamin K prophylaxis.

Cited by 169 publications

References 10 publications

Prophylactic Dosing of Vitamin K to Prevent Bleeding

Prophylactic Dosing of Vitamin K to Prevent Bleeding

Prevention of vitamin K deficiency bleeding: efficacy of different multiple oral dose schedules of vitamin K

Vitamin K and childhood cancer: a report from the United Kingdom Childhood Cancer Study

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