Haemostatic Disorder in Women with Unexplained Menorrhagia: A Tertiary Care Centre Experience from North India

Kushwaha, Rashmi; Kumar, Ashutosh; Mishra, Kusum Lata; Sankhwar, Pushp Lata; Singh, Renu

doi:10.7860/jcdr/2017/25722.9928

Cited by 7 publications

(10 citation statements)

References 14 publications

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“…One hundred and thirty‐two articles were examined in full text, of which 69 were eventually included in this systematic review. These comprised 61 case reports and series and eight cohort studies . The exact number of women with HMB is uncertain due to incomplete reporting in one article .…”

Section: Resultsmentioning

confidence: 99%

“…References: small studies, 20-37, 39-61, 63-77, 79 medium studies, 13,38,62,78,83,86 large studies. 4 women.…”

Section: Data From Case Reports and Seriesmentioning

confidence: 99%

“…These comprised 61 case reports and series 13, and eight cohort studies. 4,[81][82][83][84][85][86][87] The exact number of women with HMB is uncertain due to incomplete reporting in one article. 87 In total, 164 deliveries in women with IPRD were described.…”

Section: Re Sultsmentioning

confidence: 99%

“…86,87 Three cohort studies investigated the prevalence of IPRD in women with HMB. [83][84][85] Out of 104 women who presented at the emergency department in India with complaints of menorrhagia not caused by local pelvic pathology or hormonal disorders, 6.7% (7/104) was diagnosed with GT and 1.0% (1/104) with BSS (Table 2).…”

Section: Data From Cohort Studiesmentioning

confidence: 99%

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Menstrual and obstetrical bleeding in women with inherited platelet receptor defects—A systematic review

et al. 2020

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Introduction Women with inherited platelet receptor defects (IPRD) may have an increased risk of heavy menstrual bleeding (HMB) and postpartum haemorrhage (PPH). Aim To present a systematic overview of the literature on the prevalence and management of menstrual and obstetrical bleeding in women with IPRD. Methods Electronic databases were searched for original patient data on the prevalence and management of HMB and PPH in women with known IPRD or who were being investigated for IPRD. Results Sixty‐nine papers (61 case reports/series and 8 cohort studies) were included. Overall, studies were rated as ‘poor quality’. The included cohort studies reported HMB in 25% (13/52) of women with Bernard‐Soulier syndrome and in 22.1% (34/154) of women with Glanzmann thrombasthenia. In total, 164 deliveries in women with IPRD were described. Excessive bleeding occurred in 16.9% (11/65) of deliveries described in the largest cohort. PPH occurred in 63.2% (55/87) of deliveries described in case reports/series. PPH occurred in 73.7% (14/19) of deliveries that were not covered by prophylaxis compared with 54.2% (32/59) of deliveries that were (OR = 2.36, 95% CI 0.75‐7.40). Neonatal bleeding complications were reported in 10.0% (8/80) of deliveries. In all (6/6) deliveries with neonatal bleeding complications wherein the presence of alloantibodies was investigated, either antiplatelet or anti‐HLA antibodies were detected. Discussion/Conclusion Menstrual and particularly obstetrical bleeding problems frequently occur in women with IPRD, based on small case reports and series of poor quality. International collaboration, preferably on prospective studies, is needed to improve clinical management of women‐specific bleeding in IPRD.

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Section: Resultsmentioning

confidence: 99%

“…References: small studies, 20-37, 39-61, 63-77, 79 medium studies, 13,38,62,78,83,86 large studies. 4 women.…”

Section: Data From Case Reports and Seriesmentioning

confidence: 99%

Section: Re Sultsmentioning

confidence: 99%

Section: Data From Cohort Studiesmentioning

confidence: 99%

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Menstrual and obstetrical bleeding in women with inherited platelet receptor defects—A systematic review

et al. 2020

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“…The aetiology of menorrhaegia can be local or systemic disorders but a specific cause is identified in less than 50% of the cases and in remaining cases dysfunctional uterine bleeding is diagnosed. [ 1 ] Bernard–Soulier syndrome (BSS) was first recognized by Jean–Bernard and Jean–Pierre Soulier in 1948 in a young male patient who has prolonged bleeding time, mild-to-moderate thrombocytopenia, and very large platelets. [ 2 ] This syndrome is extremely rare, and only 100 cases have been reported, mostly in the populations of Japan, Europe, and North America.…”

Section: Introductionmentioning

confidence: 99%

Bernard–Soulier syndrome (BSS) with uncontrollable menorrhagia

Bhadra

Chakraborty

2020

Asian J Transfus Sci

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Menorrhagia is a common problem in women of reproductive age group and 5% of women between 30 and 49 years of age group consult their general practitioner for this problem. Menorrhagia occurring in adolescent age group and perimenopausal age group is chiefly due to anovulatory cycles. In perimenopausal age group, local pathology like leiomyomas can also contribute to menorrhagia. Recently, bleeding disorders like von Willebrand Disease, single coagulation factor deficiencies particularly factor XI, VIII, Factor V and platelet function disorders have been found to be prevalent in patients presenting with menorrhagia. Bernerd soulier syndrome is extremely rare haemostatic disorder due deficiency in GP IB/IX/V receptor complex present on platelet membrane which is necessary for platelet aggregation. As a result of the defect patients have prolonged bleeding time, which might vary in symptoms ranging from spontaneous self- limiting epistaxis to life threatening haemorrhage. Here we report a case of 31-year-old woman known case of Bernard soulier syndrome with severe menorrhagia treated with mirena insertion and course of complication and its management.

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Sixth Åland Island Conference on von Willebrand disease

et al. 2022

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IntroductionThe sixth Åland Islands Conference on von Willebrand disease (VWD) on the Åland Islands, Finland, was held from 20 to 22 September 2018.AimThe meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD.Results and discussionThe topics covered both clinical aspects of disease management, and biochemical and laboratory insights into the disease. The clinical topics discussed included epidemiology, diagnosis and treatment of VWD in different countries, management of children with VWD, bleeding control during surgery, specific considerations for the management of type 3 VWD and bleeding control in women with VWD. Current approaches to the management of acquired von Willebrand syndrome were also discussed. Despite significant advances in the understanding and therapeutic options for VWD, there remain many challenges to be overcome in order to optimise patient care. In comparison with haemophilia A, there are very few registries of VWD patients, which would be a valuable source of data on the condition and its management. VWD is still underdiagnosed, and many patients suffer recurrent or severe bleeding that could be prevented. Awareness of VWD among healthcare practitioners, including non‐haematologists, should be improved to allow timely diagnosis and intervention. Diagnosis remains challenging, and the development of fast, simple assays may help to facilitate accurate and rapid diagnosis of VWD.

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Haemostatic Disorder in Women with Unexplained Menorrhagia: A Tertiary Care Centre Experience from North India

Cited by 7 publications

References 14 publications

Menstrual and obstetrical bleeding in women with inherited platelet receptor defects—A systematic review

Menstrual and obstetrical bleeding in women with inherited platelet receptor defects—A systematic review

Bernard–Soulier syndrome (BSS) with uncontrollable menorrhagia

Sixth Åland Island Conference on von Willebrand disease

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