2022
DOI: 10.1021/acsomega.2c00223
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Hafnium-Based Metal–Organic Framework Nanoparticles as a Radiosensitizer to Improve Radiotherapy Efficacy in Esophageal Cancer

Abstract: Radiotherapy is one of the most widely used clinical treatments for tumors, but it faces limitations, such as poor X-ray retention at the tumor site. The use of radiosensitizers containing high Z elements is an effective way to enhance X-ray absorption. Here, we demonstrate a simple one-step method for the synthesis of UiO-66-NH 2 (Hf) metal–organic framework nanoparticles for use as radiosensitizers in radiotherapy. The UiO-66-NH 2 (Hf) nano… Show more

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Cited by 41 publications
(36 citation statements)
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“…(D) Schematic description of UiO-66-NH 2 (Hf) applied to enhance the RT effect in cancer therapy. Adapted with permission from 43 . Copyright 2022, American Chemical Society.…”
Section: Methodsmentioning
confidence: 99%
See 2 more Smart Citations
“…(D) Schematic description of UiO-66-NH 2 (Hf) applied to enhance the RT effect in cancer therapy. Adapted with permission from 43 . Copyright 2022, American Chemical Society.…”
Section: Methodsmentioning
confidence: 99%
“…RT, as a classic and effective tumor treatment method with the superiorities of deep penetration and good ability to eliminate tumor cells, uses high doses of ionizing rays to irradiate the tumor sites, achieving local cancer cells elimination and tumor cell growth inhibition 43 , 71 . However, RT exhibits poor therapeutic effects on tumors in clinical applications, which is caused by the lack of specific killing ability of tumor cells.…”
Section: Single Therapy Based On Mofsmentioning
confidence: 99%
See 1 more Smart Citation
“…793,794 Hafnium-based materials with strong X-ray absorption are used as radiosensitizers to enhance the radiotherapeutic efficacy of tumors. [795][796][797] Gold nanorods, copper sulfide, and MXenes can effectively convert light into heat energy when irradiated by near-infrared light, thus achieving tumor ablation through photothermal therapy (PTT). [651][652][653]798 Fe 3 O 4 nanoparticles effectively decompose H 2 O 2 into highly toxic OH in the tumor microenvironment and cause tumor cell death via apoptosis and ferroptosis; this method is known as chemodynamic therapy (CDT).…”
Section: Biomedicinementioning
confidence: 99%
“…The Hf analogue is actually more stable than Zr UiO-66 and has higher Lewis acidity, 20 making it especially useful in catalysis and gas separation. 16 Hf UiO-66 nanoparticles can also be used for cancer treatment 21,22 because they are relatively safe, exhibit high drug/gene loading capacities, and readily degrade in the body. [23][24][25][26] Ce UiO-66 exhibits photooxidative properties due to the facile switching of Ce 4+ /Ce 3+ redox couple, making it useful in photocatalysis, oxidation catalysis, and redox reactions.…”
Section: Introductionmentioning
confidence: 99%