Hair Growth Activity Test of White Ginger (Zingiber officinale Roscoe) Extract and Red Ginger (Zingiber officinale Rubra) Extract

Putra, Effendy De Lux; Nazliniwaty,; Syafruddin, Syafruddin; Nerdy, Nerdy

doi:10.5220/0010071904390443

Cited by 3 publications

(2 citation statements)

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“…The content of linalool, borneol, zingiberene, and zingerone was significantly different in red ginger than in white ginger. 53 Saanin et al 54 and Arunporn Itharat. 55 , evaluated the immunomodulatory effect of Zingiber officinale Roscoe ethanol extracts by enzyme-linked immunosorbent assay (for cytokines) and Griess reaction (for NO production).…”

Section: Activation Application Of Raw 2647 In Zingiberaceaementioning

confidence: 98%

RAW 264.7 Macrophage Cell Line: In Vitro Model for the Evaluation of the Immunomodulatory Activity of Zingiberaceae

2023

TJNPR

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The immune response plays an essential role in the body's defense against infection. Macrophages are promising targets against which to screen agents that modulate immune responses. In vitro analysis, primarily using cell lines, is preferred to screen bioactivity initially. RAW 264.7 cells comprise a model macrophage cell line close to primary murine macrophages. Indonesian people often use the Zingiberaceae family or “empon-empon" in the favorable treatment of several diseases, including immune disorders. This review highlights several studies of Zingiberaceae using RAW 264.7 cells, focusing on the observed immunomodulatory activity and assay methods. The research on RAW 264.7 macrophage cell line in Zingiberaceae was gathered using Scopus, PubMed, ScienceDirect, and Google Scholar from 2012-2021. Based on the reviews, the Zingiberaceae family has immunomodulatory effects by increasing or decreasing inflammatory mediators such as NO, IL-6, TNF-α, IL-1β, IL-10, and phagocytosis activity in RAW 264.7 cells. Several methods can assess the activation of RAW 264.7 cells, including cell viability assays using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT); measuring nitric oxide production (Griess reaction), cytokine production (enzyme-linked immunosorbent assay [ELISA]), and phagocytosis (neutral red uptake assay); and detecting DNA (real-time quantitative polymerase chain reaction [qPCR]). The information provided in this review presents avenues for future investigations of the immunomodulatory activity of Zingiberaceae.

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Section: Activation Application Of Raw 2647 In Zingiberaceaementioning

confidence: 98%

RAW 264.7 Macrophage Cell Line: In Vitro Model for the Evaluation of the Immunomodulatory Activity of Zingiberaceae

2023

TJNPR

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“…Linalool, borneol, zingiberene, and zingerone were found to be the primary components of the white ginger (Zingiber officinale Roscoe), which was extracted using a soxhlet extractor and hexane solvent. 15 A previous study investigated Zingerone's therapeutic effects in a carrageenan-induced inflammatory model. Using various doses of the chemical standard Zingerone (10, 20, and 40 mg/kg) considerably reduced paw edema in carrageenan-injected rats, with the highest dose of 40 mg/kg being the most effective.…”

Section: Chemical Markers Of Zingiber Officinale (Zo) Extractsmentioning

confidence: 99%

Prospects for Pharmaceutical of Zingiber officinale Extracts and Fractions by Analysis of the Chemical Markers, Safety Profile, Anti-Lipoxygenase, and Analgesic Activity

2023

TJNPR

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Ginger (Zingiber officinale) has gained recognition for its flavoring uses and its numerous health benefits. Ginger can be used in functional foods and nutraceuticals alone or combined with other herbal plants. This study aims to validate the pharmaceutical potential of the Zingiber officinale variety from the Philippines by examining the chemical composition, acute oral toxicity, anti lipoxygenase, and analgesic activities of its extracts and fractions. 6, 8, 10-Gingerols and 6, 8, 10-Shogaols were identified by high-performance liquid chromatography (HPLC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) in methanol and hexane extracts. Acute oral toxicity in mice indicated the median lethal dose (LD50) of methanol and hexane extracts of Zingiber officinale, and the 1% IPA-hexane and 50% IPA-hexane fractions obtained by solid phase extraction (SPE) was greater than 2000 mg/kg body weight. The 1% IPA-hexane fraction altered the behavioral pattern of the animals. The anti-inflammatory activity was analyzed by lipoxygenase (LOX) inhibition assay. The IC50 value for the inhibitory action of crude methanol extract on LOX was 218.00 µg/mL. The crude hexane extract IC50 value was 57.40 µg/mL. SPE fractionation of hexane extracts resulted in higher IC50 values; 72.14 µg/mL for the 1% IPAhexane fraction and 98.65 µg/mL for the 50% IPA-hexane fraction. Through in-vitro suppression of LOX, the hexane crude extracts showed more effective anti-inflammatory properties. The analgesic effect was measured using acetic acid-induced writhing in mice. All doses of the methanol and hexane extract inhibited writhing by a percentage ranging from 91-100%. The SPE fractions of the hexane extract have 78-99% inhibition. Both extracts and fractions demonstrated strong analgesic effects in the mice models.

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Isolation, Characterization and Physicochemical Properties of Starch from Ginger (Zingiber Officinale)

Nagella¹,

Manasa²,

Muchadi³

et al. 2019

IJHSP

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Ginger (Zingiber officinale) contains constituent like starch, fat, gingerol, volatile oil, the crushed ginger root and starch extracted based on properties of physicochemical that isolates using 1 % w/v sodium metabisulphite solution of achieving starch was initiate to be crystalline, non-hygroscopic powder with 1.3 swelling powder capacity, 37% of solubility capacity and gelatinization temperature at 800 C. The character study of starch was extracted and showed physicochemical properties elevate using extraction, purification, concentration, physical or biological process expressed for identification of sinking and non-reducing carbohydrates.

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Hair Growth Activity Test of White Ginger (Zingiber officinale Roscoe) Extract and Red Ginger (Zingiber officinale Rubra) Extract

Cited by 3 publications

References 0 publications

RAW 264.7 Macrophage Cell Line: In Vitro Model for the Evaluation of the Immunomodulatory Activity of Zingiberaceae

RAW 264.7 Macrophage Cell Line: In Vitro Model for the Evaluation of the Immunomodulatory Activity of Zingiberaceae

Prospects for Pharmaceutical of Zingiber officinale Extracts and Fractions by Analysis of the Chemical Markers, Safety Profile, Anti-Lipoxygenase, and Analgesic Activity

Isolation, Characterization and Physicochemical Properties of Starch from Ginger (Zingiber Officinale)

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