Hair: What is New in Diagnosis and Management?

Mesinkovska, Natasha Atanaskova; Bergfeld, Wilma F.

doi:10.1016/j.det.2012.08.005

Cited by 52 publications

(19 citation statements)

References 59 publications

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“…[2] Estrogen and androgens are the main hormones that regulate the development of FPHL. [1] In addition to sex hormones, FPHL can be associated with insulin resistance, microvascular, and inflammatory disorders. Insulin resistance reduces sex hormone-binding globulin in circulation that leads to early-onset androgenetic alopecia in men.…”

Section: Discussionmentioning

confidence: 99%

“…Insulin resistance reduces sex hormone-binding globulin in circulation that leads to early-onset androgenetic alopecia in men. [1] Miniaturization of hair follicles together with diffuse hair loss in frontal lobe can be seen in women without increased levels of androgens, which justifies the lack of response to androgen inhibitors in some women with FPHL. [34] On the other hand, FPHL cases in patients with complete androgen insensitivity syndromes support the involvement of other factors in FPHL pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…[34] On the other hand, FPHL cases in patients with complete androgen insensitivity syndromes support the involvement of other factors in FPHL pathogenesis. [1] Serum level of Vitamin D is one of the factors recently considered in approach to patients with complaints of hair loss[713] so that a recent study recommended the measurement of serum Vitamin D level as well as androgen, thyroid hormone assay, and CBC. [5]…”

Section: Discussionmentioning

confidence: 99%

“…FPHL designation is preferred in women over androgenic alopecia since the role of androgens in women is not still clear. [1]…”

Section: Introductionmentioning

confidence: 99%

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Serum vitamin D3 level in patients with female pattern hair loss

et al. 2016

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Background:Female pattern hair loss (FPHL) is the most common cause of alopecia in women, characterized by diffuse nonscarring hair loss in frontal, central, and parietal areas of the scalp. Pathophysiology of FPHL is still not well known, and it is probably a multifactorial genetic trait. FPHL is also observed in women without increased androgen levels, which raises the likelihood of androgen-independent mechanisms and explains the lack of response to antiandrogen treatments in some patients. Vitamin D is a factor that has recently been considered in dealing with these patients. The purpose of this study was to evaluate the serum levels of Vitamin D in patients with FPHL and compare it with healthy controls.Methods:In this case-control study, 45 women with FPHL were evaluated as well as the same number of healthy women matched for age, hours spent under sunlight per day, and body mass index. Serum 25(OH) D3 level was measured using ELISA.Results:60% of FPHL patients were in 15–30 years old age group with the mean standard deviation (SD) age of 29.11 (7.30) years. In the majority of patients (66.7%), severity of hair loss was Ludwig I. Mean (SD) serum Vitamin D3 level in patient and control group was 13.45 (8.40) and 17.16 (8.96), respectively. T-test showed a significant difference between the two groups in terms of Vitamin D3 serum levels (P = 0.04).Conclusions:This study indicated the correlation between the incidence of FPHL and decreased serum levels of Vitamin D3. It is recommended to evaluate serum Vitamin D3 levels as well as other hormone assays in these patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…FPHL designation is preferred in women over androgenic alopecia since the role of androgens in women is not still clear. [1]…”

Section: Introductionmentioning

confidence: 99%

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Serum vitamin D3 level in patients with female pattern hair loss

et al. 2016

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“…It is well known that androgens affect the growth of the scalp and body hair and even Hippocrates observed 2,400 years ago that eunuchs did not experience baldness (Yip et al, 2011). However, hyperandrogenism cannot be the only pathophysiologic mechanism for FPHL because the majority of women with FPHL neither have abnormal androgen levels nor do they demonstrate signs or symptoms of androgen excess (Atanaskova Mesinkovska and Bergfeld, 2013, Schmidt and Shinkai, 2015, Yip et al, 2011). Furthermore, cases have been reported in which FPHL developed in patients with complete androgen insensitivity syndrome or hypopituitarism with no detectable androgen levels (Cousen and Messenger, 2010, Orme et al, 1999).…”

Section: Pathophysiologymentioning

confidence: 99%

Hormonal therapy in female pattern hair loss

Brough

Torgerson

2017

International Journal of Women's Dermatology

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Female pattern hair loss is the most common cause of hair loss in women and one of the most common problems seen by dermatologists. This hair loss is a nonscarring alopecia in which loss occurs on the vertex scalp, generally sparing the frontal hairline. Hair loss can have significant psychosocial effects on patients, and treatment can be long and difficult. The influence of hormones on the pathogenesis of female pattern hair loss is not entirely known. The purpose of this paper is to review physiology and potential hormonal mechanisms for the pathogenesis of female pattern hair loss. We also discuss the current hormonal and hormone-modifying therapies that are available to providers as they partner with patients to treat this frustrating issue.

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A Review of Medical and Surgical Treatment Options for Androgenetic Alopecia

Rousso

Kim

2014

JAMA Facial Plast Surg

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Hair: What is New in Diagnosis and Management?

Cited by 52 publications

References 59 publications

Serum vitamin D3 level in patients with female pattern hair loss

Serum vitamin D3 level in patients with female pattern hair loss

Hormonal therapy in female pattern hair loss

A Review of Medical and Surgical Treatment Options for Androgenetic Alopecia

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