Halomonas levan-coated phospholipid based nano-carrier for active targeting of A549 lung cancer cells

Mutlu, Esra Cansever; Bahadorı, Fatemeh; Bostan, Müge Sennaroglu; Sarılmışer, Hande Kazak; ToksoyOner, Ebru; Eroğlu, Mehmet S.

doi:10.1016/j.eurpolymj.2020.110239

Cited by 10 publications

(1 citation statement)

References 49 publications

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“…Furthermore, levan was used to coat lipid nanoparticles containing paclitaxel, resulting in controlled release of the drug over a period of six hours. These coated nanoparticles exhibited increased toxicity to human A549 lung cancer cells compared to uncoated nanoparticles, potentially due to the presence of levan in the coating [ 135 ]. Recent research on antitumor therapy reports the creation of nanoparticles with an intrinsic targeting ability to deliver anticancer drugs.…”

Section: Levan Nanocarriers Developmentmentioning

confidence: 99%

Recent Developments and Applications of Microbial Levan, A Versatile Polysaccharide-Based Biopolymer

Domżał-Kędzia

Ostrowska²,

Lewińska

et al. 2023

Molecules

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Polysaccharides are essential components with diverse functions in living organisms and find widespread applications in various industries. They serve as food additives, stabilizers, thickeners, and fat substitutes in the food industry, while also contributing to dietary fiber for improved digestion and gut health. Plant-based polysaccharides are utilized in paper, textiles, wound dressings, biodegradable packaging, and tissue regeneration. Polysaccharides play a crucial role in medicine, pharmacy, and cosmetology, as well as in the production of biofuels and biomaterials. Among microbial biopolymers, microbial levan, a fructose polysaccharide, holds significant promise due to its high productivity and chemical diversity. Levan exhibits a wide range of properties, including film-forming ability, biodegradability, non-toxicity, self-aggregation, encapsulation, controlled release capacity, water retention, immunomodulatory and prebiotic activity, antimicrobial and anticancer activity, as well as high biocompatibility. These exceptional properties position levan as an attractive candidate for nature-based materials in food production, modern cosmetology, medicine, and pharmacy. Advancing the understanding of microbial polymers and reducing production costs is crucial to the future development of these fields. By further exploring the potential of microbial biopolymers, particularly levan, we can unlock new opportunities for sustainable materials and innovative applications that benefit various industries and contribute to advancements in healthcare, environmental conservation, and biotechnology.

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Section: Levan Nanocarriers Developmentmentioning

confidence: 99%