Halothane-induced malignant hyperthermia: Creatine phosphate concentration in skeletal muscle as an early indicator of the onset of the syndrome

Neural and pulmonary aspects of the porcine stress syndrome

“…Anesthetic stress consistently yielded higher CPK values than did physical stress. The CPK levels measured under both types of stress were similar to those obtained in previous studies in our laboratory and to those values reported by others (Allen et al, 1970b;Hallberg et al, 1979;Ahern et al, I98O;Altrogge et al, I98O).…”

“…Research on the etiology of the porcine stress syndrome (PSS) has followed many pathways. Investigations into pos sible abnormalities in muscle structure, function, and metab olism have received major attention (Allen et al, 1970b;Watson et al, I98O;Hallberg et al, 1979;Christian, 1974;Ahern et al, I98O;Gallant et al, 1979;Steiss et al, 19815 Gallant, I98O;Cheah and Cheah, 1981;Kerr et al, 1975;Lucke et al, 1976). The SS pig has been used as a research model for studying the etiology of a similar syn drome-malignant hyperthermia (MH) in humans.…”

Malignant Hyperthermia: Biochemical Aspects of the Acute Episode

“…The relevant changes noted by Berman's group were movement of Mg 2+ , Ca 2+ and inorganic phosphate into the extracellular space and plasma. The initial increase in membrane permeability may itself be caused by the massive depletion of creatine phosphate and ATP which occurs very early in the onset of MH, rather than to the decrease in pH, which has a slightly later time course [1,13,19]. Since MH is triggered in skeletal muscle by some as yet unknown process which increases the sarcoplasmic ionized calcium concentration, it appears likely that this calcium would activate membrane-associated phospholipases in addition to the contractile process.…”