Hancornia speciosa: Indications of gastroprotective, healing and anti-Helicobacter pylori actions

Moraes, Thiago de Mello; Rodrigues, Clenilson Martins; Kushima, Hélio; Bauab, Taís Maria; Villegas, Wagner; Pellizzon, Cláudia Helena; Brito, Alba Regina Monteiro Souza; Hiruma-Lima, Clélia Akiko

doi:10.1016/j.jep.2008.08.001

Cited by 81 publications

(67 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the case of H. speciosa, some scientific studies have showed the pharmacological potential of different parts of this plant. The extract obtained from the leaves has a hypotensive effect (Ferreira et al, 2007;Silva et al, 2011), the bark has anti-bactericidal activity (Moraes et al, 2008), and the latex has anti-inflammatory (Marinho et al, 2011) and angiogenic activities (Almeida et al, 2014). All these studies have been important to validating popular use of the mangabeira in diverse health practices.…”

Section: Discussionmentioning

confidence: 99%

“…The latex from this species is widely used in traditional medicine to treat a variety of diseases, including diarrhea, ulcer, gastritis, tuberculosis, acne and warts (Pott and Pott, 1994;Ferreira et al, 2007). Moraes et al (2008) demonstrated scientifically that this latex has gastro protective and healing activities in mice. More recently, its angiogenic properties were demonstrated using the chicken chorioallantoic membrane (CAM) assay model (Almeida et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of cytotoxicity and genotoxicity of Hancornia speciosa latex in Allium cepa root model

et al. 2016

View full text Add to dashboard Cite

The latex obtained from Hancornia speciosa Gomes (Mangabeira tree) is widely used in traditional medicine to treat a variety of diseases, including diarrhea, ulcer, gastritis, tuberculosis, acne and warts. In this study, the cytotoxicity and genotoxicity effects of H. speciosa latex on the root meristem cells of Allium cepa were examined. Onion bulbs were exposed to different concentrations of latex and then submitted to microscopic analysis using Giemsa stain. Water was used as a negative control and sodium azide as a positive control. The results showed that, under the testing conditions, the mitotic index (MI) of the onion roots submitted to latex treatment did not differ significantly from the negative control, which suggests that the latex is not cytotoxic. Low incidence of chromosome aberrations in the cells treated with H. speciosa latex was also observed, indicating that the latex does not have genotoxic effect either. The MI and the chromosome aberration frequency responded to the latex concentration, requiring more studies to evaluate the dosage effect on genotoxicity. The results indicate that in tested concentrations H. speciosa latex is probably not harmful to human health and may be potentially used in medicine.Keywords: Cerrado, popular medicine, mutagenesis. Avaliação da citotoxicidade e genotoxicidade do látex de Hancornia speciosa usando o modelo da raiz de Allium cepaResumo O látex obtido de Hancornia speciosa é amplamente utilizado na medicina popular para tratar uma variedade de doenças, tais como: diarreia, úlcera, gastrite, tuberculose, acne e verrugas. Nesse estudo, foram avaliados os efeitos citotóxicos e genotóxicos do látex de H. speciosa sobre as células meristemáticas das raízes de Allium cepa. Os bulbos das cebolas foram expostos a diferentes concentrações de látex e depois submetidos à analise microscópica usando o corante Giemsa. A água foi usada como controle negativo e a ázida sódica como controle positivo. Os resultados mostraram que o índice mitótico (IM) das raízes de cebola submetidas ao tratamento com látex, nas condições testadas, não diferiram significativamente do controle negativo, e sugerem que o látex não é citotóxico. Também foi observada uma baixa incidência de aberrações cromossômicas nas células tratadas com látex de H. speciosa, o que sugere que o látex também não possui efeito genotóxico. O IM e a frequência de aberrações cromossômicas foram dependentes da concentração de látex. Outros estudos devem ser realizados para avaliar o efeito da dose na genotoxidade. Os resultados indicam que o látex de mangabeira, nas concentrações testadas, provavelmente não é danoso para saúde humana e pode ter potencial para ser usado na medicina.Palavras-chave: Cerrado, medicina popular, mutagênese.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of cytotoxicity and genotoxicity of Hancornia speciosa latex in Allium cepa root model

et al. 2016

View full text Add to dashboard Cite

show abstract

“…It is possible to extract different types of flavonoids, anthocyanins, and tannins from the tree cork, compounds popularly used in the treatment of stomach disorders, liver and spleen obstruction, jaundice, hepatic diseases, and chronic and skin diseases (Vieira-Neto, 1997). The anti-bacterial action against Gram-positive bacterium (Staphylococcus aureus and Staphylococcus epidermidis), Gram-negative (Pseudomas aeruginosa and Salmonella enteritidis) and antifungal (Aspergillus flavus, Candida guilliermondii, Rhodotorula rubra, Cephalosporium species and Trichosporon species) (Costa et al, 2008) and gastroprotective effect of the cork extract have been effective in combating and healing gastric ulcers because of its ability to stimulate the synthesis of mucus and produce an antisecretory effect (Moraes et al, 2008).…”

Section: Antioxidants and Pharmacological Activitiesmentioning

confidence: 99%

Uses and technological prospects for the mangaba, a native fruit of Brazil

Silva¹,

Soares²,

Lédo³

et al. 2017

Afr. J. Biotechnol.

View full text Add to dashboard Cite

Mangaba (Hancornia speciosa Gomes -Apocynaceae) is a native fruit of Brazil which is of great importance in its areas of occurrence. This species has been subjected to habitat fragmentation that is mainly due to human activity, and requires conservation. The aim of the present review was to evaluate the biotechnological advances in the species. This paper deals with recent studies on the genetic diversity and bioactive compounds.

show abstract

“…Entretanto, há a necessidade de treinamento para os extrativistas de látex, a fim de que conheçam cuidados básicos para evitar excessiva contaminação microbiana. Em adição, o látex de mangabeira também possui atividades anti-úlcera (Moraes et al, 2008), antiinflamatória (Marinho et al, 2011) e antitumoral in vitro (Ribeiro et al, 2012), o que provavelmente não elimina a credibilidade no uso das preparações rotuladas como leite de janaguba.…”

Section: Qualidade Microbiológicaunclassified

Avaliação da qualidade de amostras comerciais de leite de janaguba (Himatanthus drasticus (Mart.) Plumel) em Fortaleza – Ceará

Soares

Almeida

Miranda

et al. 2016

Rev. bras. plantas med.

View full text Add to dashboard Cite

RESUMO:Os fitoterápicos à base de leite de janaguba (Himatanthus drasticus (Mart.) Plumel), usados para o tratamento de câncer, úlcera gástrica e outras doenças, são muito vendidos em mercados públicos de Fortaleza (CE). No entanto, registros mencionam que é comum a troca deste leite por látex de mangabeira (Hancornia speciosa Gomes). O trabalho objetivou avaliar a qualidade físico-química, química e microbiológica de amostras comerciais do leite de janaguba. Dez amostras comerciais foram adquiridas de um mercado de Fortaleza; quatro amostras autênticas de látex de janaguba foram obtidas da chapada do Araripe e uma amostra de látex de mangabeira foi obtida em Paracuru (CE). Foram determinados o aspecto geral, densidade, pH, resíduo seco, volume de sedimentação, perfil cromatográfico e qualidade microbiológica das amostras. Os resultados mostraram elevada contaminação microbiológica nas preparações comerciais e adulteração em seis destas amostras, o que aponta a urgente implantação de uma efetiva farmacovigilância dos fitoterápicos a fim de tornar seu consumo mais seguro e racional.Palavras-chave: fitoterápicos, qualidade, látex; janaguba; Himatanthus drasticus ABSTRACT: Quality assessment of commercial samples of janaguba's milk (Himatanthus drasticus (Mart.) Plumel) in Fortaleza -Ceará. The herbal medicines made from janaguba milk (Himatanthus drasticus (Mart.) Plumel), used to treat gastric ulcer, cancer and other diseases, and arewidely sold in the public markets of Fortaleza (CE). However, records mention that it is common to make fake copies of the milk by using mango tree latex (Hanconia speciosa Gomes). This study aimed to evaluate the chemical, physical-chemical and microbiological quality of commercial samples of janaguba milk. Ten commercial samples were purchased from a Fortaleza market; four authentic samples of janaguba latex were obtained from the Araripe plateau, and one mango tree latex sample was obtained in Paracuru (CE). We determined the general appearance, density, pH, dry residue, sedimentation volume, chromatographic profile and microbiological qualities. Results showed high microbiological contamination in the commercial preparations and evidence of tampering in six of these samples, which indicates the need for an urgent implementation of an effective pharmacovigilance strategy for herbal medicines in order to make its consumption more secure and rational.

show abstract

Hancornia speciosa: Indications of gastroprotective, healing and anti-Helicobacter pylori actions

Cited by 81 publications

References 27 publications

Evaluation of cytotoxicity and genotoxicity of Hancornia speciosa latex in Allium cepa root model

Evaluation of cytotoxicity and genotoxicity of Hancornia speciosa latex in Allium cepa root model

Uses and technological prospects for the mangaba, a native fruit of Brazil

Avaliação da qualidade de amostras comerciais de leite de janaguba (Himatanthus drasticus (Mart.) Plumel) em Fortaleza – Ceará

Contact Info

Product

Resources

About