Handedness-dependent functional organizational patterns within the bilateral vestibular cortical network revealed by fMRI connectivity based parcellation

Kirsch, V.; Boegle, Rainer; Keeser, Daniel; Kierig, E.; Ertl‐Wagner, Birgit; Brandt, Thomas; Dieterich, Marianne

doi:10.1016/j.neuroimage.2018.05.018

Cited by 40 publications

(44 citation statements)

References 95 publications

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“…color scale Fig. 3 of [1] ), which was the same in both LH (left-handed) and (RH) right-handed subgroups. “Asymmetrical” parcels were highlighted in grey.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 92%

“…color scale), which matches the colors used for RSN-affiliations of whole brain IC maps in Fig. 2 of [1] . Abr.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“… For a depiction of “unique” voxels please view Fig. 6A in [1] , and for the “common clusters” view Fig. 6B in [1] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…6A in [1] , and for the “common clusters” view Fig. 6B in [1] . Each of the 30 parcels (P) was assigned to a separate color (cp.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…color scale Fig. 3 in [1] ), which was also used for the parcel’s “unique voxels”. The colors match between (left-handed) LH and right-handed (RH) subgroups.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

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Beyond binary parcellation of the vestibular cortex – A dataset

et al. 2019

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The data-set presented in this data article is supplementary to the original publication, doi:10.1016/j.neuroimage.2018.05.01810.1016/j.neuroimage.2018.05.018 (Kirsch et al., 2018). Named article describes handedness-dependent organizational patterns of functional subunits within the human vestibular cortical network that were revealed by functional magnetic resonance imaging (fMRI) connectivity parcellation. 60 healthy volunteers (30 left-handed and 30 right-handed) were examined on a 3T MR scanner using resting state fMRI. The multisensory (non-binary) nature of the human (vestibular) cortex was addressed by using masked binary and non-binary variations of independent component analysis (ICA). The data have been made publicly available via github (https://github.com/RainerBoegle/BeyondBinaryParcellationData).

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“…color scale Fig. 3 of [1] ), which was the same in both LH (left-handed) and (RH) right-handed subgroups. “Asymmetrical” parcels were highlighted in grey.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 92%

“…color scale), which matches the colors used for RSN-affiliations of whole brain IC maps in Fig. 2 of [1] . Abr.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“… For a depiction of “unique” voxels please view Fig. 6A in [1] , and for the “common clusters” view Fig. 6B in [1] .…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…6A in [1] , and for the “common clusters” view Fig. 6B in [1] . Each of the 30 parcels (P) was assigned to a separate color (cp.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

“…color scale Fig. 3 in [1] ), which was also used for the parcel’s “unique voxels”. The colors match between (left-handed) LH and right-handed (RH) subgroups.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

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Beyond binary parcellation of the vestibular cortex – A dataset

et al. 2019

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Effects of galvanic vestibular stimulation on resting state brain activity in patients with bilateral vestibulopathy

Helmchen

Machner

Rother

et al. 2020

Human Brain Mapping

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We examined the effect of galvanic vestibular stimulation (GVS) on resting state brain activity using fMRI (rs-fMRI) in patients with bilateral vestibulopathy. Based on our previous findings, we hypothesized that GVS, which excites the vestibular nerve fibers, (a) increases functional connectivity in temporoparietal regions processing vestibular signals, and (b) alleviates abnormal visual-vestibular interaction. Rs-fMRI of 26 patients and 26 age-matched healthy control subjects was compared before and after GVS. The stimulation elicited a motion percept in all participants. Using different analyses (degree centrality, DC; fractional amplitude of low frequency fluctuations [fALFF] and seed-based functional connectivity, FC), group comparisons revealed smaller rs-fMRI in the right Rolandic operculum of patients. After GVS, rs-fMRI increased in the right Rolandic operculum in both groups and in the patients' cerebellar Crus 1 which was related to vestibular hypofunction. GVS elicited a fALFF increase in the visual cortex of patients that was inversely correlated with the patients' rating of perceived dizziness. After GVS, FC between parietoinsular cortex and higher visual areas increased in healthy controls but not in patients. In conclusion, short-term GVS is able to modulate rs-fMRI in healthy controls and BV patients.GVS elicits an increase of the reduced rs-fMRI in the patients' right Rolandic operculum, which may be an important contribution to restore the disturbed visualvestibular interaction. The GVS-induced changes in the cerebellum and the visual cortex were associated with lower dizziness-related handicaps in patients, possibly reflecting beneficial neural plasticity that might subserve visual-vestibular compensation of deficient self-motion perception. K E Y W O R D S bilateral vestibulopathy, galvanic vestibular stimulation, visual-vestibular interaction, fALFF, degree centrality, functional connectivity, rs-fMRI Abbreviations: DC, degree centrality; DHI, dizziness handicap score; fALFF, fractional amplitude of low frequency fluctuations; FC, seed-based functional connectivity; HC, healthy control; IPL, inferior parietal lobule; OP2, core vestibular area of parietal operculum; PIVC, parietoinsular vestibular cortex; ROI, region of interest; SMA, supplementary motor area; SMG, supramarginal gyrus; STG, superior temporal gyrus; VOR, vestibulo-ocular reflex; VSS, vertigo symptom scale.

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The “vestibular neuromatrix”: A proposed, expanded vestibular network from graph theory in post‐concussive vestibular dysfunction

Smith

Trofimova

Ahluwalia

et al. 2021

Human Brain Mapping

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Convergent clinical and neuroimaging evidence suggests that higher vestibular function is subserved by a distributed network including visuospatial, cognitive–affective, proprioceptive, and integrative brain regions. Clinical vestibular syndromes may perturb this network, resulting in deficits across a variety of functional domains. Here, we leverage structural and functional neuroimaging to characterize this extended network in healthy control participants and patients with post‐concussive vestibular dysfunction (PCVD). Then, 27 healthy control subjects (15 females) and 18 patients with subacute PCVD (12 female) were selected for participation. Eighty‐two regions of interest (network nodes) were identified based on previous publications, group‐wise differences in BOLD signal amplitude and connectivity, and multivariate pattern analysis on affective tests. Group‐specific “core” networks, as well as a “consensus” network comprised of connections common to all participants, were then generated based on probabilistic tractography and functional connectivity between the 82 nodes and subjected to analyses of node centrality and community structure. Whereas the consensus network was comprised of affective, integrative, and vestibular nodes, PCVD participants exhibited diminished integration and centrality among vestibular and affective nodes and increased centrality of visual, supplementary motor, and frontal and cingulate eye field nodes. Clinical outcomes, derived from dynamic posturography, were associated with approximately 62% of all connections but best predicted by amygdalar, prefrontal, and cingulate connectivity. No group‐wise differences in diffusion metrics or tractography were noted. These findings indicate that cognitive, affective, and proprioceptive substrates contribute to vestibular processing and performance and highlight the need to consider these domains during clinical diagnosis and treatment planning.

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Handedness-dependent functional organizational patterns within the bilateral vestibular cortical network revealed by fMRI connectivity based parcellation

Cited by 40 publications

References 95 publications

Beyond binary parcellation of the vestibular cortex – A dataset

Beyond binary parcellation of the vestibular cortex – A dataset

Effects of galvanic vestibular stimulation on resting state brain activity in patients with bilateral vestibulopathy

The “vestibular neuromatrix”: A proposed, expanded vestibular network from graph theory in post‐concussive vestibular dysfunction

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