Handgrip exercise reduces peripherally-inserted central catheter-related venous thrombosis in patients with solid cancers: A randomized controlled trial

Liu, Kouying; Zhou, Ye; Xie, Weiping; Gu, Zejuan; Jin, Yu; Ye, Xinhua; Chen, Xuesong; Fan, Bin; Wang, Hong; Cui, Yan

doi:10.1016/j.ijnurstu.2018.06.004

Cited by 34 publications

(53 citation statements)

References 38 publications

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“…Thrombosis is a disease involving multiple factors and systems and a major contributor to global health burden [23]. Many approaches, such as changes in the diameter of catheter [24], tuning of catheter-to-vein ratio [25], novel catheter surface coatings [26], use of catheter-locking solutions [27] or anticoagulants [28], and handgrip exercise [29], have been investigated to prevent CRT. Numerous reports on CRT were clinical studies.…”

Section: Discussionmentioning

confidence: 99%

Role of miR-92a-3p, oxidative stress, and p38MAPK/NF-κB pathway in rats with central venous catheter related thrombosis

Gan

Zhao

Yan

et al. 2020

BMC Cardiovasc Disord

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Background: miR-92a-3p and oxidative stress are reportedly associated with venous thrombosis. However, the role of miR-92a-3p and oxidative stress in catheter-related thrombosis (CRT) remains ambiguous. Herein, we studied the roles of miR-92a-3p, oxidative stress, and p38-mitogen-activated protein kinase/nuclear factor kappa-B (MAPK/NF-κB) pathway in CRT. Methods: Forty-five male rats were randomly and equally divided into control, sham operation, and CRT groups. The rats were sacrificed after 10 days. Reactive oxygen species (ROS), superoxide dismutase (SOD), and malondialdehyde (MDA) levels in the serum were determined by enzyme-linked immunosorbent assay (ELISA). The expression levels of miR-92a-3p, heme oxygenase-1 (HO-1), NF-κB p65, and p38 MAPK in the venous tissues were detected with quantitative polymerase chain reaction (qPCR) and Western blot. Results: Thrombosis was observed only in the CRT group. Compared with the levels in the control and sham operation groups, ROS and MDA significantly increased in the CRT group, but SOD significantly decreased. qPCR and Western blot results showed that miR-92a-3p, HO-1, p38 MAPK, and NF-κB p65 expression was significantly upregulated in the venous tissues of the CRT group. Moreover, miR-92a-3p was positively correlated with HO-1, which was positively correlated with p38 MAPK and NF-κB p65. Conclusion: miR-92a-3p was correlated with oxidative stress in CRT. miR-92a-3p and oxidative stress contributed to endothelial dysfunction and simultaneously was associated with CRT.

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Section: Discussionmentioning

confidence: 99%

Role of miR-92a-3p, oxidative stress, and p38MAPK/NF-κB pathway in rats with central venous catheter related thrombosis

Gan

Zhao

Yan

et al. 2020

BMC Cardiovasc Disord

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“…First is the study population. Here, we evaluated a speci c PICC population, whereas the majority of patients who undergo PICC placement in China are cancer chemotherapy patients [14]. VT [27].…”

Section: Discussionmentioning

confidence: 99%

“…Further, the risk of VTE in these patients was very low over the next 3 months (< 1%) [11][12] [13]. However,the majority of patients who undergo PICC placement in China are cancer chemotherapy patients [14].Moreover, PICC-associated UEVT is different from the usual venous thrombus, as the former presents primarily as a mural thrombus [2] [3,4]. The different study population and the different type of VT may affect D-dimer levels, and the question of whether they are also sensitive to rule out PICC-associated UEVT remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Assessment of D-dimer for ruling out peripherally inserted central catheter-associated upper extremity venous thrombosis: a diagnostic accuracy study

Liu

Zeng

et al. 2020

Preprint

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Background: With the extensive use of peripherally inserted central catheter (PICC), PICC-associated venous thrombosis (VT) has become one of the most important complications in the hospital. To reduce unnecessary color Doppler ultrasound (CDU) or imaging tests, D-dimer values are usually used to exclude VT. There is little evidence for the usefulness of the D-dimer level as an independent diagnostic marker for excluding PICC-associated VT.Objectives: To examine the effectiveness of D-dimer concentration to be used as an independent diagnostic marker for excluding PICC-associated UEVT. Design: A retrospective case cohort study. Settings: One teaching hospital in Hunan, China. Participants: In total, 281 subjects who underwent CDU and D-dimer values after PICC placement were eligible.Methods:The patients were categorized into the DVT unlikely group (<2 points) and the DVT likely group (≥2 points) according to their modified Wells score post PICC placement, before extubation. After the Wells score was determined, the patients underwent a D-dimer test and CDU within 7 days after D-dimer test.Results: 281 patients were included in the final analysis. Of them, 180 patients had D-dimer value <0.5 mgL-1. There were 39 patients with upper extremity venous thrombosis identified via CDU and 78.3% with negative predictive value of D-dimer for PICC-associated VT (95% CI: 71.7–83.7%). The negative predictive value of D-dimer for SVT was 91.0% (95% CI: 85.4–94.6%), which was higher than that for DVT (84.9%, 95% CI: 78.7–89.6%) and for VT in the cancer population (80.0%, 95% CI: 73.2–85.4%) and the non-cancer population (60.0%, 95% CI: 35.7–80.2%).Conclusion: the D-dimer concentration should not be used as a diagnostic index to rule out PICC-associated VT to avoid missed diagnosis of PICC-related venous thrombosis, which may cause adverse consequences or may even be life-threatening.

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“…After the patients squeezed the elastic ball for 10 seconds, they were tired out and allowed to relax for 10 seconds; the maximum blood flow of the axillary vein was detected by ultrasound. 9 In study by Ayse and colleagues, 10 patients with PICC were required to exercise for 20 minutes a day for 5 days a week and to contract and relax the forearm muscles by gripping and relaxing a ball for 4 seconds to increase blood flow to the forearm.…”

Section: Factors Influencing the Effects Of Resistance Exercise On Hementioning

confidence: 99%

Research Progress of Oxidative Stress and MicroRNAs in the Prevention of Catheter-Related Thrombus Under Resistance Exercise

Cui

Ying

et al. 2020

Clin Appl Thromb Hemost

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Central venous access devices (CVADs) have completely changed the care for patients who require long-term venous access. With the widespread use of CVADs, the incidence of catheter-related thrombus (CRT) has increased. Catheter-related thrombus is a common complication in patients who use CVADs and is mainly caused by endothelial injury, blood stasis, and hypercoagulability. In recent years, the correlations between oxidative stress (OS) and microRNA (miRNA) and CRT have become a hot topic in clinical research. When a catheter punctures the vessel wall, it causes OS damage to the vascular endothelial cells, leading to a series of CRT diseases. MicroRNAs can regulate the mechanism of thrombus and play an important role in the formation of anti-thrombus. Numerous studies have shown that resistance exercise can reduce the level of OS in vascular endothelial cells, inhibit vascular endothelial cell dysfunction, and maintain the stability of hemodynamics and biochemical state. In the current work, the recent studies on the effects of resistance exercise on OS and miRNA in vascular endothelial cells were reviewed.

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Handgrip exercise reduces peripherally-inserted central catheter-related venous thrombosis in patients with solid cancers: A randomized controlled trial

Cited by 34 publications

References 38 publications

Role of miR-92a-3p, oxidative stress, and p38MAPK/NF-κB pathway in rats with central venous catheter related thrombosis

Role of miR-92a-3p, oxidative stress, and p38MAPK/NF-κB pathway in rats with central venous catheter related thrombosis

Assessment of D-dimer for ruling out peripherally inserted central catheter-associated upper extremity venous thrombosis: a diagnostic accuracy study

Research Progress of Oxidative Stress and MicroRNAs in the Prevention of Catheter-Related Thrombus Under Resistance Exercise

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