Handgrip strength is not associated with risk of venous thromboembolism: a prospective cohort study

Kunutsor, Setor K; Mäkikallio, Timo H.; Voutilainen, Ari; Laukkanen, Jari A.

doi:10.1080/14017431.2020.1751267

Cited by 10 publications

(17 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Participants were a randomly selected sample from a general population of Kuopio and the surrounding area in Eastern Finland. Study design, recruitment methods, and assessment of lifestyle factors, medical history, and blood-based markers have been described previously [15][16][17][18][19][20][21][22]. Of the 3,433 randomly selected men who participated in the baseline study conducted between March 1984 and December 1989, 3,235 were found to be eligible.…”

Section: Methodsmentioning

confidence: 99%

Circulating Serum Copper Is Associated with Atherosclerotic Cardiovascular Disease, but Not Venous Thromboembolism: A Prospective Cohort Study

Kunutsor

Dey

Laukkanen

2021

Pulse

Self Cite

View full text Add to dashboard Cite

Background and Objective: Serum copper has been linked to the risk of atherosclerotic cardiovascular disease (CVD). However, the potential association between serum copper and venous thromboembolism (VTE) is not known. The principal aim was to evaluate the potential prospective association between serum copper and VTE risk. A secondary aim was to confirm or refute previously reported associations between serum copper and atherosclerotic CVD. Methods: Serum copper was measured at baseline using atomic absorption spectrometry in 2,492 men aged 42–61 years without a history of VTE in the Kuopio Ischemic Heart Disease prospective cohort study. Cox regression models were used to calculate hazard ratios (HRs) with 95% confidence interval (CI) for VTE. Results: During a median follow-up of 27.0 years, 166 VTE events occurred. The risk of VTE per 1 standard deviation increase in serum copper in age-adjusted analysis was HR: 1.02; 95% CI: 0.88–1.20, which was attenuated to HR: 0.99; 95% CI: 0.82–1.19, following further adjustment for several established and emerging risk factors. Comparing the top versus bottom tertiles of serum copper, the corresponding adjusted HRs were 1.16 (95% CI: 0.80–1.66) and 1.11 (95% CI: 0.74–1.68), respectively. In 1,901 men without a history of coronary heart disease (CHD), the multivariable-adjusted HR for CHD was 1.32 (95% CI: 1.10–1.59) comparing extreme tertiles of serum copper. Conclusion: In middle-aged Finnish men, we confirmed previously reported associations between high serum copper levels and increased risk of atherosclerotic CVD, but serum copper was not associated with future VTE risk. Other large-scale prospective studies conducted in women, other age-groups, and other populations are needed to confirm or refute these findings.

show abstract

Section: Methodsmentioning

confidence: 99%

Circulating Serum Copper Is Associated with Atherosclerotic Cardiovascular Disease, but Not Venous Thromboembolism: A Prospective Cohort Study

Kunutsor

Dey

Laukkanen

2021

Pulse

Self Cite

View full text Add to dashboard Cite

show abstract

“…We used data based on the Kuopio Ischemic Heart Disease (KIHD) Risk Factor study, a general population-based prospective cohort study comprising middle-aged men (42-61 years) who were recruited from Kuopio in eastern Finland. The study design, recruitment methods, assessment of lifestyle factors, medical history, and blood-based markers have been described in previous related reports [19][20][21][22][23][24][25].…”

Section: Methodsmentioning

confidence: 99%

Circulating Serum Magnesium and the Risk of Venous Thromboembolism in Men: A Long-Term Prospective Cohort Study

Kunutsor

Laukkanen

2020

Pulse

Self Cite

View full text Add to dashboard Cite

Background and Objective: Serum magnesium, an essential trace element involved in processes that regulate cardiovascular function, has been linked to the risk of atherosclerotic cardiovascular disease. However, the potential association between serum magnesium and venous thromboembolism (VTE) has not been previously investigated. We aimed to assess the prospective association of serum magnesium with the risk of VTE. Methods: Serum magnesium was measured using atomic absorption spectrometry in 2,361 men aged 42–61 years with no history of VTE at baseline in the Kuopio Ischemic Heart Disease prospective cohort. Cox regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for VTE. Results: A total of 159 incident VTE events were recorded during a median follow-up of 27.1 years. The risk of VTE per 1 SD increase in serum magnesium in the age-adjusted analysis was (HR 1.30; 95% CI 0.46–3.69). The association remained consistent in analyses adjusted for systolic blood pressure, body mass index, total cholesterol, triglycerides, smoking status, a history of type 2 diabetes, a history of coronary heart disease, medication for dyslipidemia, alcohol consumption, physical activity, socioeconomic status, serum active calcium, high-sensitivity C-reactive protein, and a history of cancer (HR 1.38; 95% CI 0.48–3.96). Comparing the extreme tertiles of serum magnesium, the corresponding adjusted HRs were 1.17 (95% CI 0.81–1.70) and 1.17 (95% CI 0.81–1.70), respectively. Conclusion: In a middle-aged Caucasian male population, serum-circulating magnesium was not associated with a future risk of VTE. Further studies in women, other age groups, and other populations are required to generalize these findings.

show abstract

“…Methods for participant recruitment, baseline physical examinations, blood sampling and measurements have been described in previous reports. 4,[6][7][8] Baseline examinations and measurements were performed between March 10, 1998 and February 2, 2000.…”

mentioning

confidence: 99%

Handgrip Strength and Risk of Atrial Fibrillation

Kunutsor

Mäkikallio

Jae

et al. 2020

The American Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

Handgrip strength is not associated with risk of venous thromboembolism: a prospective cohort study

Cited by 10 publications

References 34 publications

Circulating Serum Copper Is Associated with Atherosclerotic Cardiovascular Disease, but Not Venous Thromboembolism: A Prospective Cohort Study

Circulating Serum Copper Is Associated with Atherosclerotic Cardiovascular Disease, but Not Venous Thromboembolism: A Prospective Cohort Study

Circulating Serum Magnesium and the Risk of Venous Thromboembolism in Men: A Long-Term Prospective Cohort Study

Handgrip Strength and Risk of Atrial Fibrillation

Contact Info

Product

Resources

About