HAP Coatings for Biomedical Applications: Biocompatibility and Surface Protection Against Corrosion of Ti, Ti6Al4V and AISI 316L SS

Büyüksağiş, Aysel; Çiftçi, Nihal

doi:10.1134/s2070205120040085

Cited by 10 publications

(5 citation statements)

References 26 publications

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“…Cytotoxicity and biocompatibility are extremely important properties for practical biomedical applications. 23 The cytotoxicities of our HAp, 2.5Ag-HAp, 5Ag-HAp, 2.5Ag/2.5Zn co-doped HAp, and 2.5Ag/2.5Mg co-doped HAp were then evaluated by using the MTT assay on MC3T3-E1 cells. Figure 7 shows the results for different extraction concentrations of 25, 50, 100, 150, 200, 250, and 300 μg/mL after 72 h of incubation.…”

Section: Resultsmentioning

confidence: 99%

Investigation of Antibacterial Activity and Cell Viability of Ag/Mg and Ag/Zn Co-doped Hydroxyapatite Derived from Natural Limestone

et al. 2021

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Improving the antibacterial activity to avoid infections and keeping the biocompatibility at a safe level of HAp-based materials is highly important for biomedical applications. In this work, we investigate the antibacterial activity of 2.5Ag/2.5Mg co-doped HAp and 2.5Ag/2.5Zn co-doped HAp toward Escherichia coli bacteria. Moreover, their biocompatibility for osteoblastic cells (MC3T3-E1 cells) was also evaluated. The physical properties were characterized with necessary characterization tools such as X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and Brunauer–Emmett–Teller. Both 2.5Ag/2.5Mg and 2.5Ag/2.5Zn co-doped HAp consist of hydroxyapatite (HAp) and beta calcium triphosphate (β-TCP) phases. The antibacterial test reveals that 2.5Ag/2.5Mg co-doped HAp or 2.5Ag/2.5Zn co-doped HAp has an outstanding antibacterial activity with a killing rate of 99 ± 1%. More importantly, the cell viability for osteoblast cells with 2.5Ag/2.5Mg and 2.5Ag/2.5Zn co-doped HAp promotes the proliferation much more effectively than 2.5Ag-doped HAp or 5Ag-doped HAp.

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Section: Resultsmentioning

confidence: 99%

Investigation of Antibacterial Activity and Cell Viability of Ag/Mg and Ag/Zn Co-doped Hydroxyapatite Derived from Natural Limestone

et al. 2021

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“…As stated before, all laser cladded areas were subject to multiple dynamic reactions, all of which are impacted by the possible modulation of the processing temperature and convertible dilution of the input materials [16,49]. It is important to note that the XRD data confirmed, for both types of sample, that part of the original BHA source compound (indexed with a HA-type phase, Ca 5 (PO 4 ) 3 (OH), ICDD-PDF4: 04-010-6314) was preserved after the laser processing at beam powers of 500 and 600 W. In tandem, the tetracalcium diphosphate (TTCP, Ca 4 (P 2 O 9 ), monoclinic-ICDD-PDF4: 01-076-7650) emerged as a direct result of the HA decomposition at high temperatures [30,[52][53][54]. At increased beam powers, the BHA phase vanished and only the derived biocompatible TTCP phase [54] could be clearly outlined.…”

Section: Xrd Investigationsmentioning

confidence: 99%

“…The osseointegration of a metal component is always challenging. Calcium-phosphate-based materials (CaPs), most frequently hydrox-yapatite (HA), are applied as coatings to metal surfaces due to their physiologically (e.g., chemically, structurally, and biologically) comparable properties to the natural bone mineral component [13,14,[30][31][32][33][34]. Bioceramic HA-based materials may be formed by laser cladding on Ti substrate either directly, by using an already synthesized material (from synthetic or natural resources [14,16,26,[35][36][37][38]) as a source material, or indirectly, by utilizing two sets of materials (one Ca-rich material and one P-rich material) and subjecting them to a reactive deposition process [7,14].…”

Section: Introductionmentioning

confidence: 99%

Modulated Laser Cladding of Implant-Type Coatings by Bovine-Bone-Derived Hydroxyapatite Powder Injection on Ti6Al4V Substrates—Part I: Fabrication and Physico-Chemical Characterization

et al. 2022

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The surface physico-chemistry of metallic implants governs their successful long-term functionality for orthopedic and dentistry applications. Here, we investigated the feasibility of harmoniously combining two of the star materials currently employed in bone treatment/restoration, namely, calcium-phosphate-based bioceramics (in the form of coatings that have the capacity to enhance osseointegration) and titanium alloys (used as bulk implant materials due to their mechanical performance and lack of systemic toxicity). For the first time, bovine-bone-derived hydroxyapatite (BHA) was layered on top of Ti6Al4V substrates using powder injection laser cladding technology, and then subjected, in this first stage of the research, to an array of physical-chemical analyses. The laser processing set-up involved the conjoined modulation of the BHA-to-Ti ratio (100 wt.% and 50 wt.%) and beam power range (500–1000 W). As such, on each metallic substrate, several overlapped strips were produced and the external surface of the cladded coatings was further investigated. The morphological and compositional (SEM/EDS) evaluations exposed fully covered metallic surfaces with ceramic-based materials, without any fragmentation and with a strong metallurgical bond. The structural (XRD, micro-Raman) analyses showed the formation of calcium titanate as the main phase up to maximum 800 W, accompanied by partial BHA decomposition and the consequential advent of tetracalcium phosphate (markedly above 600 W), independent of the BHA ratio. In addition, the hydrophilic behavior of the coatings was outlined, being linked to the varied surface textures and phase dynamism that emerged due to laser power increment for both of the employed BHA ratios. Hence, this research delineates a series of optimal laser cladding technological parameters for the adequate deposition of bioceramic layers with customized functionality.

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“…When utilized as a biomaterial, HAp must possess a high level of biocompatibility [68], which has a Ca/P ratio is 1.67. However, the purpose of this study was to evaluate the potential use of the HAp as a bioceramic ultrafiltration membrane.…”

Section: An Outlook: Bioceramic Ultrafiltration Membrane Applicationmentioning

confidence: 99%

Marine-Derived Biowaste Conversion into Bioceramic Membrane Materials: Contrasting of Hydroxyapatite Synthesis Methods

et al. 2021

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Marine-derived biowaste increment is enormous, yet could be converted into valuable biomaterial, e.g., hydroxyapatite-based bioceramic. Bioceramic material possesses superiority in terms of thermal, chemical, and mechanical properties. Bioceramic material also has a high level of biocompatibility when projected into biological tissues. Tuning the porosity of bioceramic material could also provide benefits for bioseparation application, i.e., ultrafiltration ceramic membrane filtration for food and dairy separation processes. This work presents the investigation of hydroxyapatite conversion from crab-shells marine-based biowaste, by comparing three different methods, i.e., microwave, coprecipitation, and sol–gel. The dried crab-shells were milled and calcinated as calcium precursor, then synthesized into hydroxyapatite with the addition of phosphates precursors via microwave, coprecipitation, or sol–gel. The compound and elemental analysis, degree of crystallinity, and particle shape were compared. The chemical compounds and elements from three different methods were similar, yet the degree of crystallinity was different. Higher Ca/P ratio offer benefit in producing a bioceramic ultrafiltration membrane, due to low sintering temperature. The hydroxyapatite from coprecipitation and sol–gel methods showed a significant degree of crystallinity compared with that of the microwave route. However, due to the presence of Fe and Sr impurities, the secondary phase of Ca9FeH(PO4)7 was found in the sol–gel method. The secondary phase compound has high absorbance capacity, an advantage for bioceramic ultrafiltration membranes. Furthermore, the sol–gel method could produce a snake-like shape, compared to the oval shape of the coprecipitation route, another benefit to fabricate porous bioceramic for a membrane filter.

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HAP Coatings for Biomedical Applications: Biocompatibility and Surface Protection Against Corrosion of Ti, Ti6Al4V and AISI 316L SS

Cited by 10 publications

References 26 publications

Investigation of Antibacterial Activity and Cell Viability of Ag/Mg and Ag/Zn Co-doped Hydroxyapatite Derived from Natural Limestone

Investigation of Antibacterial Activity and Cell Viability of Ag/Mg and Ag/Zn Co-doped Hydroxyapatite Derived from Natural Limestone

Modulated Laser Cladding of Implant-Type Coatings by Bovine-Bone-Derived Hydroxyapatite Powder Injection on Ti6Al4V Substrates—Part I: Fabrication and Physico-Chemical Characterization

Marine-Derived Biowaste Conversion into Bioceramic Membrane Materials: Contrasting of Hydroxyapatite Synthesis Methods

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