Haplotype analysis of the apolipoprotein A5 gene in patients with the metabolic syndrome

Kisfali, Péter; Mohás, Márton; Maász, Anita; Polgár, Noémi; Hadarits, Ferenc; Markó, Lajos; Brasnyó, Pál; Horvatovich, Katalin; Oroszlán, Tamás; Bagosi, Zoltán; Bujtor, Zoltán; Gasztonyi, Beáta; Rinfel, József; Wittmann, István; Melegh, Béla

doi:10.1016/j.numecd.2009.05.001

Cited by 31 publications

(51 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because the articles by Grallert et al (2007) and Ong et al (2011) included two separate groups, respectively, these groups were considered as two independent studies. Finally, 12 studies from 10 articles (Grallert et al, 2007;Yamada et al, 2007;Dallongeville et al, 2008;Hsu et al, 2008;Komurcu-Bayrak et al, 2008;Mattei et al, 2009;Kisfali et al, 2010;Niculescu et al, 2010;Ong et al, 2011;Vasilopoulos et al, 2011) were included in our meta-analysis. Among 10 publications, only Ong' study (Ong et al, 2011) Table 1.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Among the 12 studies, 11 studies from 9 articles (Grallert et al, 2007;Yamada et al, 2007;Hsu et al, 2008;KomurcuBayrak et al, 2008;Mattei et al, 2009;Kisfali et al, 2010;Niculescu et al, 2010;Ong et al, 2011;Vasilopoulos et al, 2011) involving 4374 MetS patients and 4628 no-MetS controls were included for the analysis of the -1131T > C polymorphism and MetS. 7 studies from 6 articles (Grallert et al, 2007;Komurcu-Bayrak et al 2008;Mattei et al, 2009;Kisfali et al, 2010;Niculescu et al, 2010;Vasilopoulos et al, 2011) involving 3405 MetS patients and 5329 no-MetS controls were included for the analysis of the c.C56G polymorphism and MetS.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…As higher triglyceride is one crucial risk factor in the development of many diseases, including MetS, the polymorphism of the ApoA5 gene may be involved in MetS. Indeed, several studies in different populations have found the association between the ApoA5 polymorphism and the risk of MetS (Grallert et al, 2007;Yamada et al, 2007;Dallongeville et al, 2008;Hsu et al, 2008;Komurcu-Bayrak et al, 2008;Mattei et al, 2009;Kisfali et al, 2010;Niculescu et al, 2010;Ong et al, 2011;Vasilopoulos et al, 2011). However, these results are not quite consistent; therefore, we conducted a meta-analysis to clarify the exact association between the ApoA5 polymorphism and the risk of MetS.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Apolipoprotein A5 Gene Polymorphism and Risk for Metabolic Syndrome: A Meta-Analysis

Liu

Yang²,

Chen³

et al. 2012

Genetic Testing and Molecular Biomarkers

View full text Add to dashboard Cite

show abstract

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Apolipoprotein A5 Gene Polymorphism and Risk for Metabolic Syndrome: A Meta-Analysis

Liu

Yang²,

Chen³

et al. 2012

Genetic Testing and Molecular Biomarkers

View full text Add to dashboard Cite

show abstract

“…APOA5 influences the triglyceride metabolism by two possible mechanisms: (1) , have been reported to associate with elevated fasting or postprandial circulating triglyceride levels. Some of them were also found to be risk factors for hypertriglyceridemia, metabolic syndrome, cardio-and cerebrovascular diseases like ischemic stroke, CAD [57,58,[60][61][62][63][64][65][66][67][68][69][70][71]. In a cohort of Indian patients, rs662799 C allele was shown to associate significantly with CAD-T2DM phenotype compared with CAD without T2DM [72].…”

Section: Apolipoprotein A5 (Apoa5)mentioning

confidence: 99%

Radioprotectors and Mitigators: Current Status

Yazlovitskaya¹

2013

J Bioequiv Availab

View full text Add to dashboard Cite

Type 2 diabetes mellitus represents a significant global health problem contributing to a considerably increased atherosclerotic burden and cardio-and cerebrovascular risk. Type 2 diabetes mellitus has high incidence and prevalence affecting both genders at any time of life worldwide. Presence of diabetes related phenotypes may represent risk for other metabolic diseases, cardio-, and cerebrovascular disorders, as well. The etiology of type 2 diabetes mellitus is complex; several environmental-, and genetic factors have been identified, which can contribute to the pathogenesis of the disease. Nowadays, numerous genetic loci have been shown to associate with type 2 diabetes mellitus and other diabetic traits, and the number of the identified susceptibility variants is expected to still grow due to rapidly developing field of candidate gene -, linkage-, and genome-wide association studies. The identified genetic variants can affect various metabolic pathways like glucose-, and lipid metabolism, signal transduction and can have effects on transcriptional-and translational levels. Among these, lipid alterations especially increased levels of triglycerides have been found to correlate to various disease phenotypes. It is also well known, that genetic variants identified in triglyceride metabolism are often shared as presence of these SNPs can confer risk for various disorders equally representing a susceptibility link between disorders. The scope of the current review is to summarize shared susceptibility variants, which have effect on the circulating lipid levels and represent risk for type 2 diabetes mellitus.

show abstract

“…The conditions were similar for all polymorphisms: a 2-minute initial denaturation at 96°C was followed by 35 cycles of 20 seconds at 96°C; 20 s at 60°C; and 20 s at 72°C; the final extension at 72°C was 5 min long. The amplification was carried out in a final volume of 50 µl containing 5 µl reaction buffer (500 mM KCl, 14 mM MgCl 2 , 10 mM Tris-HCl, pH 9.0), 1 µl 50 mM MgCl 2 , 0.2 mM of each dNTP, 1 U of Taq polymerase, 0.2 mM of each reaction specific primers and 1 µg DNA [22].…”

Section: Study Populationmentioning

confidence: 99%

Stepwise Positive Association Between APOA5 Minor Allele Frequencies and Increasing Plasma Triglyceride Quartiles in Random Patients with Hypertriglyceridemia of Unclarified Origin

Hadarits

Kisfali

Mohás

et al. 2010

Pathol. Oncol. Res.

View full text Add to dashboard Cite

Apolipoprotein A5 (ApoA5) gene and its protein product play a central role in the complex regulation of circulating triglyceride levels in humans. Naturally occurring variants of the apolipoprotein A5 gene have been associated with increased triglyceride levels and have been found to confer risk for cardiovascular diseases. In our study, four polymorphisms, the T-1131C, IVS3+G476A, T1259C, and C56G alleles of APOA5 were analyzed in a total of 436 patients by polymerase chain reaction-restriction fragment length polymorphism methods. The randomly selected patients were classified into four quartile (q) groups based on triglyceride levels (q1: TG<1.31 mmol/l; q2: 1.31-2.90 mmol/l; q3: 2.91-4.85 mmol/l; q4: TG>4.85 mmol/l). We observed significant stepwise increasing association between the four APOA5 minor allele carrier frequencies and plasma triglyceride quartiles: -1131C (q1: 4.44%; q2: 8.95%; q3: 12.9%; q4: 20.6%), IVS3 + 476A (q1: 4.44%; q2: 5.79%; q3: 11.1%; q4: 19.7%), 1259C (q1: 4.44%; q2: 6.84%; q3: 11.1%; q4: 20.6%) and 56G (q1: 5.64%; q2: 6.31%; q3: 11.16%; q4: 11.9%). The serum total cholesterol and high density lipoprotein-cholesterol levels also showed allele-dependent differences in the quartiles. The findings presented here revealed a special arrangement of APOA5 minor alleles in patients with different serum triglyceride ranges in Hungarians.

show abstract

Haplotype analysis of the apolipoprotein A5 gene in patients with the metabolic syndrome

Cited by 31 publications

References 29 publications

Apolipoprotein A5 Gene Polymorphism and Risk for Metabolic Syndrome: A Meta-Analysis

Apolipoprotein A5 Gene Polymorphism and Risk for Metabolic Syndrome: A Meta-Analysis

Radioprotectors and Mitigators: Current Status

Stepwise Positive Association Between APOA5 Minor Allele Frequencies and Increasing Plasma Triglyceride Quartiles in Random Patients with Hypertriglyceridemia of Unclarified Origin

Contact Info

Product

Resources

About