Haplotypes of the<i>IL10</i>Gene as Potential Protection Factors in Leprosy Patients

Garcia, Patrícia; Alencar, Dayse O.; Pinto, Pablo; Santos, Ney Pereira Carneiro dos; Salgado, Cláudio Guedes; Sortica, Vinicius Albuquerque; Hutz, Mara H.; Ribeiro-dos-Santos, Ândrea; Santos, Sidney Emanuel Batista dos

doi:10.1128/cvi.00334-13

Cited by 13 publications

(15 citation statements)

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“…Genetic polymorphisms may modify the biological pathways of periodontitis. The action of multiple genes can contribute to the relative risk of susceptibility and severity, but these effects may be confounded by the influence of population substructure (7,15,37). We analyzed the genetic contribution of Africans, Europeans and Amerindians of an admixed population using a panel of 48 AIMs that are capable of precisely distinguishing with low statistical error and cost (25).…”

Section: Discussionmentioning

confidence: 99%

“…Polymorphisms in cytokine genes often affect cytokine expression profiles and may play an important role in resistance or susceptibility to CP (8,14). Specifically regarding the IL-10 gene, single nucleotide polymorphisms (SNPs) (A-1082G (rs1800896), C-819T (rs1800871) and C-592A (rs1800872)) are associated with diseases with different pathologies, such as leprosy and type 2 diabetes mellitus (15,16). The literature reveals a strong correlation of the allele IL-10* -1082 G with the overexpression of IL-10; in contrast, the allele IL-10* -1082 A is associated with the low expression of IL-10.…”

Section: Introductionmentioning

confidence: 99%

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Effect of ancestry on i interleukin-10 i haplotypes in chronic periodontitis

et al. 2017

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Chronic periodontitis is caused by an inflammatory reaction of the periodontal tissues and alveolar bone. This inflammation is caused by periodontopathic bacteria located in the subgingival biofilm, resulting in inflammatory reactions that may lead to loss of attachment. This tissue destruction is a consequence of host immune and inflammatory responses to specific periodontal pathogens and their metabolic products. Cytokines modulate the immune response, altering its efficiency in the competition against pathogens and increasing periodontal susceptibility. This study investigated genetic polymorphisms in Interleukin 10 (A-1082G, C-819T and C-592A) in 205 individuals from an admixed Brazilian population. A significantly increased risk of developing chronic periodontitis was observed in individuals with low IL-10 production and Amerindian ancestry. These results suggest that the polymorphisms A-1082G, C-819T, and C-592A, which are associated with ancestry, are involved in the susceptibility to the development of chronic periodontitis in an admixed northern Brazilian population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of ancestry on i interleukin-10 i haplotypes in chronic periodontitis

et al. 2017

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“…Ancestral origin can be associated with variations in immunological responses, metabolic processes, host responses to infection, and drug treatment patterns which justify studies investigating ancestral components in admixed populations (Suarez-Kurtz and Pena 2006;Sortica et al 2012;Franceschini et al 2014;Shim et al 2014;Suarez-Kurtz and Botton 2015). Amerindian ancestry is associated with a smaller risk of leprosy (Garcia et al 2013) and Alzheimer's disease (Benedet et al 2012), but a higher risk of systemic lupus erythematous (Seldin et al 2008;Sanchez et al 2010). European ancestry is associated with increased risk of multiple sclerosis (Brum et al 2013), sleep apnea (Guindalini et al 2010) and death from heart failure (Cardena et al 2014) while obesity (Fernández and Shiver 2004), asthma and IgE production (Vergara et al 2009) share alleles of African origin.…”

Section: Discussionmentioning

confidence: 99%

Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry

et al. 2016

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Ancestry information can be useful in investigations of diseases with a genetic or infectious background. As the Brazilian population is highly admixed physical traits tend to be poor indicators of ancestry. The assessment of ancestry by ancestry informative markers (AIMs) can exclude the subjectivity of self-declared ethnicity and reported family origin. We aimed to evaluate the reliability of self-reported ethnicity or reported family origin as indicators of genomic ancestry in a female population from the Southeast of Brazil. Two cohorts were included: 404 women asked to self-report their ethnicity (Pop1) and 234 women asked to report their family's origin (Pop2). Identification of AIMs was performed using a panel of 61 markers and results were plotted against parental populations-Amerindian, Western European and Sub-Saharan African-using Structure v2.3.4. In Pop1 57.4 % of women self-reported as white, 34.6 % as brown and 8.0 % as black. Median global European, Amerindian and African contributions were 66.8, 12.6 and 16.6 %. In Pop2, 66.4 % of women declared European origin, 23.9 % African origin and 26.9 % Amerindian. Median global European, Amerindian and African contributions were 80.8, 7.3 and 7.6 %, respectively. Only 31.0 and 21.0 % of the global variation in African and European contributions, respectively, could be explained by self-reported ethnicity and reported family origin only accounted for 20.0 and 5.0 % of the variations observed in African and European ancestries, respectively. Amerindian ancestry did not influence self-reported ethnicity or declared family origin. Neither self-reported ethnicity nor declared family origin are reliable indicators of genomic ancestry in these Brazilian populations.

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“…Interestingly, Amerindian ancestry also affects the frequency of other diseases. For instance, Amerindian ancestry is associated with an increased frequency of lupus erythematosus (Alarcon-Riquelme et al, 2016), but Amerindians have a lower risk of contracting leprosy, psoriasis, or Alzheimer's disease (Benedet et al, 2012;Garcia et al, 2013;Parisi, Symmons, Griffiths, & Ashcroft, 2013). Also, they differ from Europeans in 18…”

Section: Prevalence Of Vitiligo In Brazil-a Population Surveymentioning

confidence: 99%