Robotic systems have been developed to handle very small objects, but their use remains complex and necessitates long-duration training. Simulators, such as molecular simulators, can provide access to large amounts of raw data, but only highly trained users can interpret the results of such systems. Haptic feedback in teleoperation, which provides force-feedback to an operator, appears to be a promising solution for interaction with such systems, as it allows intuitiveness and flexibility. However several issues arise while implementing teleoperation schemes at the micro-nanoscale, owing to complex force-fields that must be transmitted to users, and scaling differences between the haptic device and the manipulated objects. Major advances in such technology have been made in recent years. This chapter reviews the main systems in this area and highlights how some fundamental issues in teleoperation for micro-and nano-scale applications have been addressed. The chapter considers three types of teleoperation, including: (1) direct (manipulation of real objects); (2) virtual (use of simulators); and (3) augmented (combining real robotic systems and simulators). Remaining issues that must be addressed for further advances in teleoperation for micro-nanoworlds are also discussed, including: (1) comprehension of phenomena that dictate very small object (< 500 micrometers) behavior; and (2) design of intuitive 3-D manipulation systems. Design guidelines to realize an intuitive haptic feedback teleoperation system at the micro-nanoscale level are proposed.Keywords: Teleoperation, haptics, micromanipulation, nanomanipulation, molecular simulation, user testing.3 Micro-nanomanipulation is the manipulation of objects ranging from 1 mm down to 1 nm.The primary challenge for this type of manipulation is facilitating user interaction with an intangible world. This challenge has often been approached through the use of simulations (see Figure 1). In order to facilitate performance in such applications, new methods must be developed for user understanding of the physical mechanisms that dictate behavior of very small objects, including artificial or biological microscopic objects. Furthermore, users must be provided with intuitive interfaces to facilitate, for example, micro-nanoassembly operations (i.e., assembly of components ranging from 1 nm to 1 mm). To overcome these challenges, there is a need for teleoperation systems that enable the manipulation of objects in 3-D, while providing feedback on object interaction forces in real-time. This chapter proposes design guidelines for such systems. Users must be provided with knowledge about phenomena at this scale and intuitive interfaces 4 for object manipulation. Photos in figure come from Liu, Sun, Wang, and Lansdorp (2007) and Bargiel, Rabenorosoa, Clévy, Gorecki, and Lutz (2010).At the micro-nano scale, manual interaction with objects is impossible, owing to very small physical size of objects, as well as the fragility of the objects and tools, the complexity of force...