With the continuous increase in the number of software-based attacks, there has been a growing effort towards isolating sensitive data and trusted software components from untrusted third-party components. A hardware-assisted intraprocess isolation mechanism enables software developers to partition a process into isolated components and in turn secure sensitive data from untrusted components. However, most of the existing hardware-assisted intra-process isolation mechanisms in modern processors, such as ARM and IBM Power, rely on costly kernel operations for switching between trusted and untrusted domains. Recently, Intel introduced a new hardware feature for intraprocess memory isolation, called Memory Protection Keys (MPK), which enables a user-space process to switch the domains in an efficient way. While the efficiency of Intel MPK enables developers to leverage it for common use cases such as Code-Pointer Integrity, the limited number of unique domains ( 16) prohibits its use in cases such as OpenSSL where a large number of domains are required. Moreover, Intel MPK suffers from the protection key use-after-free vulnerability. To address these shortcomings, in this paper, we propose an efficient intra-process isolation technique for the RISC-V open ISA, called SealPK, which supports up to 1024 unique domains. SealPK prevents the protection key useafter-free problem by leveraging a lazy de-allocation approach. To further strengthen SealPK, we devise three novel sealing features to protect the allocated domains, their associated pages, and their permissions from modifications or tampering by an attacker. To demonstrate the feasibility of our design, we implement SealPK on a RISC-V Rocket processor, provide the OS support for it, and prototype our design on an FPGA. We demonstrate the efficiency of SealPK by leveraging it to implement an isolated shadow stack on our FPGA prototype.