Finding the optimal parameters for multi-pump control system of water supply is regarded as a difficult problem with blind source separation (BSS). A motor acceleration or deceleration curve of water supply can be assumed as a weighted sum by feature control parameters, such as pipe line pressure, water flux, and sleeping interval, etc. With the help of destruction of separation model, a group of optimal parameters are found. The solution is to the optimal control parameters for multi-pump control system of water supply. The test results showed that separating precision is 0.856% for two main feature parameters. And an excellent agreement is found with the numerical simulation and the actual test parameters.