Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-κB activation

Huang, Tom; Tran, Van Hoan; Duke, Rujee K.; Tan, Sharon; Chrubasik, Sigrun; Roufogalis, Basil D.; Duke, Colin C.

doi:10.1016/j.jep.2005.08.055

Cited by 109 publications

(72 citation statements)

References 20 publications

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“…of triplicate experiments. The pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6 mediate and regulate immunity and inflammation during the inflammatory process (Trikha et al 2003;Huang et al 2006). These cytokines play key roles in the induction of inflammatory process (Kim et al 2016).…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory effect of ozonated krill (Euphausia superba) oil in lipopolysaccharide-stimulated RAW 264.7 macrophages

Kim

Lee

et al. 2018

Fish Aquatic Sci

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Background: Inflammation has been known to associate with many human diseases. The objective of this study was to evaluate an anti-inflammatory effect of ozonated krill (Euphausia superba) oil, which was prepared by the treatment of krill oil using ozone gas. The anti-inflammatory activity was evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Results: Ozonated krill oil significantly inhibited nitric oxide (NO) production and suppressed the mRNA and protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in LPS-stimulated RAW 264.7 macrophages. Ozonated krill oil also reduced the mRNA expression of inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in LPS-stimulated RAW 264.7 macrophages. To elucidate the mechanism underlying the anti-inflammatory activity of ozonated krill oil, we evaluated the effects of ozonated krill oil on the activation of mitogen-activated protein kinases (MAPKs) pathway. Ozonated krill oil suppressed the LPS-stimulated phosphorylation of p38 MAPK and c-Jun N-terminal kinases (JNK).

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Section: Resultsmentioning

confidence: 99%

Anti-inflammatory effect of ozonated krill (Euphausia superba) oil in lipopolysaccharide-stimulated RAW 264.7 macrophages

Kim

Lee

et al. 2018

Fish Aquatic Sci

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“…Although, it is worthy to mention that the whole-plant extracts seem to have a better therapeutic effect than those obtained from isolated parts [60]. Harpagoside inhibited in vitro the synthesis of various proinflammatory mediators via suppression of iNOS and COX-2 expression through inhibition of NF-kappa B activation [61], but showed no anti-inflammatory activity in one animal model of inflammation (carrageenan-induced paw edema) [55]. The scientists suggested that other phytochemicals than harpagoside may be contributors to the anti-inflammatory effect of HP [55,62].…”

Section: Harpagophytum Procumbens Fam Pedaliaceaementioning

confidence: 99%

Phytomedicine in Joint Disorders

Dragoș

Gîlcă

Găman

et al. 2017

Preprint

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Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from painkillers to biological agents) is potent, but frequently associated with serious, even life-threatening side effects. Used for millennia in traditional herbalism, medicinal plants are a promising alternative, with lower rate of adverse events and an efficiency frequently comparable with that of conventional drugs. Nevertheless, their mechanism of action is in many cases elusive and/or uncertain. Even many of them have been proved effective in studies done in vitro or on animal models, there is a scarcity of human clinical evidence. The purpose of this review is to summarise the available scientific information on these joint-friendly medicinal plants, which have been already tested in human studies: Arnica montana, Boswellia spp., Curcuma spp., Equisetum arvense, Harpagophytum procumbens, Salix spp., Sesamum indicum, Symphytum officinalis, Zingiber officinalis, Panax notoginseng, Whitania somnifera.

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“…All of these findings strongly suggest that harpagoside perturb the arachidonic acid pathway. In addition, it was reported that harpagoside inhibits lipopolysaccharide (LPS)-induced production of inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α resulting from the both IκBα degradation and the nuclear translocation of NF-κB in RAW 264.7 cells [39] . Furthermore, harpagoside significantly reduces TNF-α secretion in PMA-differentiated THP-1 cells [40] .…”

Section: Underlying Molecular Mechanisms For Anti-inflammatory Activimentioning

confidence: 99%

A Systematic Review on Anti-Inflammatory Activity of Harpagoside

Park¹

2016

Journal of Biochemistry and Molecular Biology Research

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Harpagoside, a major iridoid glycoside present in Harpagophytum procumbens (devil's claw), has been reported to show antiinflammatory, anti-rheumatic, and analgesic activities. The present study is aimed to provide a comprehensive overview of antiinflammatory activity of harpagoside. Peer-reviewed articles on potent anti-inflammatory effects of harpagoside were acquired from Scopus, ScienceDirect, and SciFinder. This review provides a comprehensive advance on the pharmacological studies to confirm potent anti-inflammatory effects of harpagoside in vitro, in vivo, and clinical studies. Although a number of researches have demonstrated anti-inflammatory activities of harpagoside, further intensive studies are required to confirm its efficacy for treating inflammatory diseases as a therapeutic agent.

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Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-κB activation

Cited by 109 publications

References 20 publications

Anti-inflammatory effect of ozonated krill (Euphausia superba) oil in lipopolysaccharide-stimulated RAW 264.7 macrophages

Anti-inflammatory effect of ozonated krill (Euphausia superba) oil in lipopolysaccharide-stimulated RAW 264.7 macrophages

Phytomedicine in Joint Disorders

A Systematic Review on Anti-Inflammatory Activity of Harpagoside

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