Häufigkeit Uno Korrelative Beziehung Von Diagnostischen Kriterien Bei Der Tierschuppenallergie

Schultze‐Werninchaus, G.; Gonsior, E; Thiel, Claudia; Kroidl, Rolf F.; Meier-Sydow, J

doi:10.1111/j.1398-9995.1976.tb01478.x

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…Previous reports on investigations of horse epithelia allergen extracts showed large variations in al lergenic potencies and antigenic compositions [6][7][8][9][10][11]. In most of these investigations well-defined self-pre pared extracts were compared with unspecified, arbi trarily selected commercially available extracts, al lowing no systematical comparison.…”

Section: Discussionmentioning

confidence: 99%

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Allergens of Horse Epithelium

Franke¹,

Maasch²,

Wahl³

et al. 1990

Int Arch Allergy Immunol

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We investigated five horse epithelial allergen extracts prepared from different qualities of raw material by several biochemical and immunochemical methods. Horse serum albumin and horse serum were used to identify serum-related antigens. We found high similarities as well as marked differences between the extracts. There were strong differences in the protein contents, the protein patterns obtained by isoelectric focusing and sodium dodecyl sulfate polyacrylamide gel electrophoresis, the total allergenic activities obtained by radioallergosorbent test inhibition assays and the amounts and numbers of serum-related proteins. The patterns of dander-related allergens in crossed radioimmunoelectrophoresis were similar but showed partly strong differences in allergen concentrations. Allergen compositions determined by blotting methods showed only minor differences between the investigated epithelial extracts. It appears that some of the differences, e.g. the content of serum-related proteins, depend on the way the different raw materials are prepared. Because serum-related extract components are not considered as major allergens, their content should be low in horse epithelial allergen extracts. For this reason whole skin cannot be recommended as starting material for horse epithelium allergen extract preparation.

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Section: Discussionmentioning

confidence: 99%

“…To avoid ambiguous diagnostic results [6][7][8] or strong differences in allergenic activity between al lergen extracts from horse epithelia [9][10][11] not only the methods used for the extraction but also the source and the manufacturing process of the raw ma terial itself should be harmonized.…”

Section: Introductionmentioning

confidence: 99%

Allergens of Horse Epithelium

Franke¹,

Maasch²,

Wahl³

et al. 1990

Int Arch Allergy Immunol

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“…Among domestic animals, cat and dog are the most common sensitizers in different parts of the world [5,7,13,20). Several studies concerning animal dander allergens have indicated the possible importance of serum albumin as an allergen in dan der extracts.…”

Section: Introductionmentioning

confidence: 99%

Dog Serum Albumin as an Allergen

Vanto

Viander

Schwartz

1982

Int Arch Allergy Immunol

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To study the allergenicity of dog serum albumin (DSA) in dog-sensitive subjects, we investigated 203 asthmatic children by means of the skin prick test (SPT), the radioallergosorbent test (RAST) and the in vitro lymphocyte stimulation test. Significant SPT reactions to DSA were observed in only 9 out of 80 subjects with a significantly positive SPT reaction to dog dander and hair (DDH). Analogously, positive DSA RAST results were observed only in a minority of the cases with a positive DDH RAST. Significant SPT reactions to DSA were not observed in subjects with a negative clinical history of dog allergy, or in subjects with a negative reaction to DDH in the SPT or in the provocation test. DSA induced remarkable lymphocyte stimulation in only 1 subject, who also had a significant SPT reaction to DSA. DSA-specific serum IgG antibody titers measured by ELISA were not found to correlate with DSA SPT or DSA RAST.

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Allergische Atemwegsobstruktion (Allergisches — extrinsic — Asthma bronchiale)

Fuchs¹

1979

Bronchitis · Asthma Emphysem

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Häufigkeit Uno Korrelative Beziehung Von Diagnostischen Kriterien Bei Der Tierschuppenallergie

Cited by 9 publications

References 16 publications

Allergens of Horse Epithelium

Allergens of Horse Epithelium

Dog Serum Albumin as an Allergen

Allergische Atemwegsobstruktion (Allergisches — extrinsic — Asthma bronchiale)

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