HbA1c, fasting plasma glucose and the prediction of diabetes: Inter99, AusDiab and D.E.S.I.R.

Soulimane, Soraya; Simon, Dominique; Shaw, Jonathan E.; Witte, Daniel R.; Zimmet, Paul; Vol, Sylviane; Borch‐Johnsen, Knut; Magliano, Dianna J.; Vistisen, Dorte; Balkau, Beverley

doi:10.1016/j.diabres.2011.06.003

Cited by 19 publications

(27 citation statements)

References 30 publications

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“…Mean HbA 1c differed among studies, more than that of glucose, as we have shown in other analyses [28, 29]. Indeed, in the Japanese-Americans study [24], HbA 1c had a much higher mean than in other studies.…”

Section: Discussionmentioning

confidence: 45%

HbA1c, fasting and 2 h plasma glucose in current, ex- and never-smokers: a meta-analysis

et al. 2013

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Aim The relations between smoking and glycaemic parameters are not well explored. We compare HbA1c, fasting plasma glucose (FPG) and 2-hour plasma glucose (2H-PG) in current-, ex- and never-smokers. Methods This meta-analysis used individual data from 16 886 men and 18 539 women without known diabetes, in 12 DETECT-2 consortium studies and in the French D.E.S.I.R. and TELECOM studies. Means of the three glycaemic parameters in current-, ex- and never-smokers were modelled by linear regression, with study as a random factor. The I2 statistic evaluated heterogeneity among studies. Results HbA1c was 0.10 (95%CI:0.08,0.12) % [1.1 (0.9,1.3) mmol/mol] higher in current-smokers and 0.03 (0.01,0.05) % [0.3 (0.1,0.5) mmol/l] higher in ex-smokers, compared with never-smokers. For FPG, there was no significant difference between current- and never-smokers: −0.004 (−0.03,0.02) mmol/l but FPG was higher in ex-smokers: 0.12 (0.09,0.14) mmol/l. In comparison to never-smokers, 2H-PG was lower: −0.44 (−0.52,−0.37) mmol/l in current-smokers, with no difference for ex-smokers: 0.02 (−0.06,0.09) mmol/l. There was a large and unexplained heterogeneity among studies, with I2 always higher than 50%: after stratification by sex and adjustment for age and BMI, I2 changed little. In this study population, current-smokers had a prevalence of diabetes as screened by HbA1c, 1.30% higher and that screened by 2H-PG, 0.52% lower than in comparison to never-smokers. Conclusion Current-smokers had a higher HbA1c and a lower 2H-PG than never-smokers, across this heterogeneous group of studies; this will effect the chances of smokers being diagnosed with diabetes.

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Section: Discussionmentioning

confidence: 45%

HbA1c, fasting and 2 h plasma glucose in current, ex- and never-smokers: a meta-analysis

et al. 2013

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“…Using IFG as a screening method for T2DM is well known. Other biomarkers, such as HbA1c and 1‐ and 2‐h plasma glucose, have been shown to have a greater association with T2DM progression. In busy Hong Kong primary care clinics, the oral glucose tolerance test (OGTT) is not routinely performed because of poor patient acceptance of the time required to stay in the clinic for the blood test.…”

Section: Discussionmentioning

confidence: 99%

Progression from impaired fasting glucose to type 2 diabetes mellitus among Chinese subjects with and without hypertension in a primary care setting 在中国初级保健机构中合并以及不合并高血压的受试者从空腹血糖受损进展到2型糖尿病的调查

Luk

Wong

et al. 2014

Journal of Diabetes

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“…19 The HbA1c 5.7% screening threshold for prediction of future diabetes appears to be less sensitive, more specifıc, and have higher positive predictive value than FPG when 100 mg/dL is used as the screening threshold. 35 Finally, high HbA1c in combination with IFG has a higher positive predictive value for subsequent diabetes than high HbA1c or IFG alone, indicating that use of repeated tests, when available, will likely improve the effıciency of risk-stratifıcation and prevention efforts. 36 …”

Section: Epidemiologic Basis For Using Hba1c To Diagnose Prediabetesmentioning

confidence: 98%

Implications of Risk Stratification for Diabetes Prevention

Gregg¹,

Geiss²,

Zhang³

et al. 2013

American Journal of Preventive Medicine

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HbA1c, fasting plasma glucose and the prediction of diabetes: Inter99, AusDiab and D.E.S.I.R.

Cited by 19 publications

References 30 publications

HbA1c, fasting and 2 h plasma glucose in current, ex- and never-smokers: a meta-analysis

HbA1c, fasting and 2 h plasma glucose in current, ex- and never-smokers: a meta-analysis

Progression from impaired fasting glucose to type 2 diabetes mellitus among Chinese subjects with and without hypertension in a primary care setting 在中国初级保健机构中合并以及不合并高血压的受试者从空腹血糖受损进展到2型糖尿病的调查

Implications of Risk Stratification for Diabetes Prevention

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