1982
DOI: 10.1111/j.1365-2265.1982.tb01609.x
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hCGβ PRODUCING PINEAL CHORIOCARCINOMA

Abstract: A patient is described with tumours in the region of the pineal gland and anterior hypothalamus associated with high levels of hCG beta in the serum and cerebrospinal fluid (CSF). He presented aged 19, with hypopituitarism, but persistent secondary sexual characteristics. LH immunoreactivity in serum was due to the hCG beta which probably caused the elevated level of testosterone. Following cranial irradiation the tumour became undetectable and hCG beta was eradicated from the serum and CSF. The patient later … Show more

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Cited by 21 publications
(3 citation statements)
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“…The response was remarkable, confirming the high radio-sensitivity of germ cell tumours [21 ]. Cerebrospinal irradiation was employed to reduce the risk of metastasis to the spinal cord which may occur after treatment of the primary tumour [9,21], His subsequent progress will be monitored by BhCG and aFP levels in blood and CSF. and chemotherapy will be introduced if necessary.…”
Section: Discussionmentioning
confidence: 99%
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“…The response was remarkable, confirming the high radio-sensitivity of germ cell tumours [21 ]. Cerebrospinal irradiation was employed to reduce the risk of metastasis to the spinal cord which may occur after treatment of the primary tumour [9,21], His subsequent progress will be monitored by BhCG and aFP levels in blood and CSF. and chemotherapy will be introduced if necessary.…”
Section: Discussionmentioning
confidence: 99%
“…This mechanism has been used to explain preco cious puberty in patients with germ cell tu mours of the testis, liver and other sites [7,8]. Surprisingly, there are few cases documented by immunoassay of intracranial tumours se creting either BhCG, with [10][11][12][13][14] or without [2,5,7,9,15,16] precocity, or aFP alone [17] or in combination [5,6], Below the age of 18 years approximately half the tumours in the pineal region are germ cell in origin [18] . Based on a review of the histological findings in 35 cases [2] we estimate that more than half of these would have either tropho blastic elements and secrete BhCG or endodermal sinus tumours and secrete aFP.…”
Section: Discussionmentioning
confidence: 99%
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