HDL capacity to inhibit LDL oxidation in well-trained triathletes

Brites, Fernando; Zago, Valeria; Verona, Julián; Muzzio, María Luz; Wikinski, Regina; Schreier, Laura

doi:10.1016/j.lfs.2005.12.015

Cited by 42 publications

(42 citation statements)

References 45 publications

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“…Creatine kinase and LDH activities were significantly higher in athletes than in sedentary individuals (Evelson et al, 2002). A significantly higher LDH activity was determined in athletes compare to control group including sedentary subjects (Brites et al, 2006).…”

Section: Discussionmentioning

confidence: 79%

Effects of acute twelve minute run test on oxidative stress and antioxidant enzyme activities

Sarıtaş

Uyanik²,

Hamurcu³

et al. 2011

Afr. J. Pharm. Pharmacol.

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The aim of this study was to investigate the effects of 12 min run test on oxidative stress, some antioxidant enzyme activities, and muscle and DNA damage. Twenty two healthy and well trained male athletes were recruited to this study. The12 min run test, cooper test, was applied to the participating athletes. The blood samples were taken before, immediately after and 24 h after the run test, and sera and plasma were separated and then stored at -80°C until the analysis. Serum MDA and NO levels as the indicators of oxidative damage; serum SOD and CAT, plasma GPx activities as the indicators of antioxidant defense system; serum 8-OHdG as the indicator of DNA damage, CK and LHD enzyme activities as the indicators of muscle damage, and glucose level were measured. Serum SOD, NO, CAT, and 8-OHdG levels showed no significant changes before, immediately after and 24 h after the run rest. There was a significant decrease in serum MDA level immediately after exercise, which is returned to baseline level after 24 h-rest period (p<0.05). Serum LHD (p<0.001) and CK activities (p<0.05) and glucose level (p<0.001) increased immediately after exercise but these increments returned to pre-exercise level after 24 h-rest period. Acute twelve minute endurance exercise increased CK, LDH and glucose decreased oxidative stress and whereas has no effect on antioxidant capacity and DNA damage in trained young men.

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Section: Discussionmentioning

confidence: 79%

Effects of acute twelve minute run test on oxidative stress and antioxidant enzyme activities

Sarıtaş

Uyanik²,

Hamurcu³

et al. 2011

Afr. J. Pharm. Pharmacol.

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show abstract

“…Similarly, Burneiko et al (2006) stated that aerobic exercises continuing for 8 weeks decreased LDH activities. In contrast to these findings, it was reported that sportsmen had higher LDH values than sedentary individuals in the studies performed (Brites et al, 2006;Evelson et al, 2002).…”

Section: Discussionmentioning

confidence: 61%

Effects of endurance training on exhaustive exercise-induced oxidative stress markers

Revan¹,

Erol²

2011

Afr. J. Pharm. Pharmacol.

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This study was aimed to investigate the effects of endurance training on lipid peroxidation and antioxidant enzyme levels in young adults. Twenty four male students participated in this study. Subjects were divided into two groups as training group (n=12) and control group (n=12). Subjects in the training groups performed running exercise 25 to 60 min/day, three days/week for eight weeks at an intensity of 50 to 70% of target heart rate. Blood samples collected at rest and after exhaustive exercise before and after 8 weeks, were analyzed for the determination of plasma lipid hydroperoxide (LOOH) level, and activities of glutathione peroxidase (GPx), catalase (CAT) and lactate dehydrogenase (LDH). LOOH level in the training group significantly decreased after the post-training period (p<0.05), but did not alter in the control group (p>0.05). LDH activities significantly increased both control and training groups after the exhaustive exercise (p<0.05). LDH activity was found significantly higher in control group than training group both at rest and after exhaustive exercise (p<0.05). GPx was not significantly altered by training and exhaustive exercise in both groups (p>0.05). In the training group, exhaustive exercise significantly increased CAT level after training period (p<0.05). Consequently, it can be said that endurance training is effective in prevention of lipid peroxidation caused by exhaustive exercise.

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“…And blood AE activity was higher in sportsmen 59) . PON1 has been found in the HDL2 species of HDL in particles enriched in triacylglycerols 60) .…”

Section: Effects Of Exercise On Hdls and Clinical Significancementioning

confidence: 85%

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

Turgay

Şişman

Aksu

2015

JAT

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Aim: Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL). The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1), including basal PON1, salt-stimulated PON1 (SPON1), and arylesterase (AE) activities, of serum, HDL, and HDL subgroups (HDLs; HDL and its subgroups) and its relationship with PON1-Q192R phenotype (PON1P). Methods: Our study included 18 Turkish national female judoists (mean age: 17.9 0.8 years). Before and after 5 months of anaerobic training, critical speed (CS), TDPON1 activities, cholesterol levels in the serum and supernatants of HDLs obtained by polyethylene glycol, and other major blood lipids and lipoproteins (BLLPs) including triglycerides were determined using blood samples taken after overnight fasting. PON1P groups (PGs) were categorized as QQ (QG; persons with low activity) and R carriers (QR RR) (RG; persons with high activity) according to SPON1/AE activity ratios. The results were considered statistically significant at P ≤ 0.05. Results: Anaerobic training resulted in significantly increased the cholesterol levels of HDLs (except HDL2-C) in all subjects, but not HDLs-C in PGs. Anaerobic training resulted in significant increases in most TDPON1 activities of serum and HDLs in all subjects and (except AE) in PGs, whereas SPON1 and HDL2 AE activities increased only in the RG, which was related to PON1P. However, PON1P was not related to other measured markers, including basal BLLP profiles. Conclusions: Anaerobic training improved most TDPON1 activities of serum and HDLs and HDLs -C levels (except HDL2-C) in all subjects, but not HDLs-C in PGs. The beneficial effects of anaerobic training on SPON1 and HDL2 AE activities were depend on PON1P. The lack of response of HDL2-C to anaerobic exercise will require further research. J Atheroscler Thromb, 2015; 22: 313-326.

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HDL capacity to inhibit LDL oxidation in well-trained triathletes

Cited by 42 publications

References 45 publications

Effects of acute twelve minute run test on oxidative stress and antioxidant enzyme activities

Effects of acute twelve minute run test on oxidative stress and antioxidant enzyme activities

Effects of endurance training on exhaustive exercise-induced oxidative stress markers

Effects of Anaerobic Training on Paraoxonase-1 Enzyme (PON1) Activities of High Density Lipoprotein Subgroups and Its Relationship with PON1-Q192R Phenotype

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