Head and neck cancer in young people: a series of 52 SCCs of the oral tongue in patients aged 35 years or less

Abstract

The WHO performance status was excellent for all patients. Thirty-seven were classified as T1-T2 and 38 were N0. All of them except one were treated with curative intent. Treatment failures were observed in 25 patients (48%). Four patients could be successfully salvaged after SCCOT recurrence or progression. The disease-free survival (DFS) was 52% at 5 years. The 5-year overall survival (OS) rate was 64%. Factors that affected the OS were invasion of the floor (p=0.009), cross over of the midline (p=0.02), positive lymph nodes (p=0.02), and the lack of disease control (p=0.0001).

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

“…Five of the 10 papers about the tumor-node-metastasis (TNM) Staging System indicated that a large amount of patients were diagnosed as T1 and/or T2 (8,(13)(14)(15)20) , being stages T3 and T4 (extensive tumors) predominant in other works (7,(10)(11)(12)18) .…”

“…As for sample size, the number of participants ranged from 10 to 2,223 young subjects, as described in Table 1. Age distribution of patients varied: individuals considered young were those aged 18-39 years (7,8,10,11) (23.5%), < 30 years (13,20) (3,6,8,9,(11)(12)(13)(14)(16)(17)(18)(19)(20)(21) ( Table 1).…”

“…The criterion N0 (absence of metastasis in regional lymph nodes) (7,8,(12)(13)(14)(18)(19)(20) prevailed in eight studies, and M0 (absence of distance metastasis) was described in all the 10 studies. On the subject of clinical stage, seven works reported that nearly all the patients were in stages III and IV (more advanced tumors) (3, 10-12, 16, 18, 20) , and two showed predominance of stages I and II (8,13) (Table 3).…”

“…In relation to histopathological grading, following the malignancy grading system proposed by the World Health Organization (WHO) (5) , out of the 11 articles that presented data on the degree of differentiation of the lesion, eight reported that nearly all tumors were moderately differentiated (3,(14)(15)(16)(18)(19)(20)(21) , and three considered the majority of them well differentiated (3,(14)(15)(16)(18)(19)(20)(21) .…”

Head and Neck Squamous Cell Carcinoma in Iranian Patients and Risk Factors in Young Adults: a Fifteen-Year Study

“…The incidence rate of HNSCC has reached 0.4-3.6% in patients younger than 40 years which has drawn physicians' attention to the changing face of the disease (Llewellyn et al, 2001). On the other hand, recent studies have revealed differences of the risk factors and prognosis of HNSCC, in patients younger than 40 and the older patients, although controversy still exists regarding disease outcomes in young and old patients: some authors report a worse prognosis of the disease in the young compared to the old (Mallet et al, 2009;Kaminagakura et al, 2010;Soudry et al, 2010;Bachar et al, 2011;Kostrzewska-Poczekaj et al, 2012) while other studies have not found a significant clinical difference, or even a more favorable prognosis in younger patients (Luna-Ortiz et al, 2011). In fact, even if the tumors are histologically more mature and less malignant in younger patients compared to older ones, they are usually more advanced clinically at the time of diagnosis due to late referral of young patients to physicians (Shiboski et al, 2005;Sink et al, 2011).…”