Health-related quality of life is impaired in active collagenous colitis

Hjortswang, Henrik; Tysk, Curt; Bohr, Johan; Benoni, Cecilia; Vigren, Lina; Kilander, Anders; Larsson, Laşse; Taha, Yesuf; Ström, Magnus

doi:10.1016/j.dld.2010.06.004

Cited by 65 publications

(59 citation statements)

References 26 publications

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“…Although LC and CC share histological features, they are considered two related but separate entities. The characteristic symptoms include chronic watery diarrhea, urgency and episodic fecal incontinence, which have a significant impact on the patient's social functioning and quality of life [3].…”

Section: Introductionmentioning

confidence: 99%

The epidemiology of microscopic colitis: a 10-year pathology-based nationwide Danish cohort study

Bonderup

Wigh

Nielsen

et al. 2015

Scandinavian Journal of Gastroenterology

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Section: Introductionmentioning

confidence: 99%

The epidemiology of microscopic colitis: a 10-year pathology-based nationwide Danish cohort study

Bonderup

Wigh

Nielsen

et al. 2015

Scandinavian Journal of Gastroenterology

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“…The aetiology to MC is unknown, but autoimmunity, inflammation and bile acid malabsorption have been suggested [2,5]. It is described that MC impairs health-related quality of life (HRQOL) [6]. Several studies have shown a symptomatic overlap between MC and irritable bowel syndrome (IBS) [7,8], and the combination of these two diseases further impairs gastrointestinal symptoms and psychological well-being [8].…”

Section: Introductionmentioning

confidence: 99%

Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis

Roth¹,

Bengtsson²,

Ohlsson³

2013

European Journal of Internal Medicine

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Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis. Link to publication Citation for published version (APA): Roth, B., Bengtsson, M., & Ohlsson, B. (2013). Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis. European Journal of Internal Medicine, 24(6), 573-578. DOI: 10.1016573-578. DOI: 10. /j.ejim.2013 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal

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“…Budesonide treatment induces clinical remission in around 80% of patients and improves stool consistency and passage frequency rapidly [214]. Since stool consistency has been shown to be the main determinant for impaired QOL [215], budesonide treatment has a great impact on the patient's everyday life. Risk factors for MC include age, use of nonsteriodal anti-inflammatory drugs (NSAIDs) or proton-pump inhibitors, antidepressants or antipsychotic drugs [216].…”

Section: Inflammatory Bowel Disease and Microscopic Colitismentioning

confidence: 99%

Aquaporins in Infection and Inflammation

Holm¹

2016

Linköping University Medical Dissertations

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About the cover:The front cover displays a human, blood-derived macrophage stained for aquaporin 9.During the course of the research underlying this thesis, Angelika Holm was enrolled in Forum Scientium, a multidisciplinary doctoral programme at Linköping University Printed by LiU-Tryck, Linköping, Sweden, 2016 "Be brave, even if you're not, pretend to be. No one can tell the difference."To that young, awkward, tall girl who dared to dream of something else, something more:You did it. SUPERVISOR Elena VikströmDepartment of Clinical and Experimental Medicine Linköping University Linköping Sweden When cells of the innate immune system encounter pathogens they need to respond and prepare for migration and phagocytosis and do so through volume regulatory processes. The Gramnegative bacterium Pseudomonas aeruginosa utilizes a small molecule-based communication system, called quorum sensing (QS) to control the production of its virulence factors and biofilms. We found that P. aeruginosa with a complete QS system elicits a stronger phagocytic response in human blood-derived macrophages compared to its lasI-/rhlI-mutant lacking the production of the QS molecules N-butyryl-L-homoserine lactone (C4-HSL) and N-3-oxododecanoyl-L-homoserine lactone (3O-C12-HSL). Infection with P. aeruginosa further increases the expression of AQP9 and induces re-localisation of AQP9 to the front and trailing ends of macrophages. Moreover, the 3O-C12-HSL alone elevates the expression of AQP9, redistribute the water channel to the front and rear ends and increases the cell area and volume of macrophages. Both infection with the wild type P. aeruginosa and the treatment with 3O-C12-HSL change the nano-structural architecture of the AQP9 distribution in macrophages. ASSISTANT SUPERVISORS Karl-Eric MagnussonViruses use the intracellular machinery of the invaded cells to produce and assemble new viral bodies. Intracellular AQPs are localised in a membranes of cellular organelles to regulate their function and morphology. C3H10T1/2 fibroblasts transiently expressing green fluorescent protein (GFP)-AQP6 show a reduced expression of AQP6 after Hazara virus infection and an increased cell area. Overexpressing AQP6 in C3H10T1/2 cells reduces the infectivity of Hazara virus indicating that AQP6 expression has a protective role in virus infections.Ion and water channels in the epithelial cell lining tightly regulate the water homeostasis. In microscopic colitis (MC), patients suffer from severe watery diarrhoeas. For the first time, we have shown that the expression of AQP1, 8 and 11 and the sodium/hydrogen exchanger NHE1 are reduced in colonic biopsies from MC patients compared to healthy control individuals. Following treatment with the glucocorticoid budesonide the patients experienced a rapid recovery and we observed a restored or increased expression of the AQPs and NHE1 during treatment, suggesting a role for AQPs in the diarrhoeal mechanisms in MC.Taken together, this thesis provides new evidence on the importance of water homeostasis regulatio...

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Health-related quality of life is impaired in active collagenous colitis

Cited by 65 publications

References 26 publications

The epidemiology of microscopic colitis: a 10-year pathology-based nationwide Danish cohort study

The epidemiology of microscopic colitis: a 10-year pathology-based nationwide Danish cohort study

Diarrhoea is not the only symptom that needs to be treated in patients with microscopic colitis

Aquaporins in Infection and Inflammation

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