Hearing, vestibular reactivity and postural stability after 21-day period at high altitude

Neri, G; Pugliese, Mara; D’Orazio, Flavia; Mastronardi, Valentina; Nicola, Marta Di; Morabito, Caterina; Guarnieri, Simone

doi:10.1007/s11332-014-0182-0

Cited by 3 publications

(9 citation statements)

References 23 publications

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“…The six studies measuring PTA in this scoping review [ 10 , 11 , 36 , 37 , 42 , 43 ] almost consistently showed that HA induced alterations in hearing thresholds, although with differences in magnitude and frequency-dependence. Among variability factors, the six studies included either simulated [ 10 , 36 , 37 ] and real HA conditions [ 11 , 42 , 43 ], with consequent differences in the exposure duration, magnitude, and in the pattern of exposure (e.g., single sessions versus intermittent hypoxia).…”

Section: Discussionmentioning

confidence: 71%

“…The eight studies evaluating the effects of HA on the inner auditory function in a real environment are shown in Table 3 . Among these studies, three performed PTA [ 11 , 42 , 43 ], three characterized OAE [ 35 , 41 , 42 ], and three analyzed AER [ 15 , 16 , 40 ]. Only one study analyzed the effects of a chronic exposure at HA [ 43 ], while all the others investigated a pattern of acute exposure to HA with a period of acclimatization involving physical exercise.…”

Section: Resultsmentioning

confidence: 99%

“…Focusing on acute HA exposure, Neri and colleagues did not find any significant difference in PTA measurements performed in seven subjects before and after an expedition to a maximal altitude of 6400 m [ 42 ]. Fehrenbacher et al investigated the combined effect of noise and HA on hearing function by performing PTA before and after white noise exposure to induce temporary threshold shift (TTS), at 1400 m (Kathmandu), 5300 m (Ghorak Shep), and at return to 1400 m after HA exposure [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

“…DPOAE levels decreased at altitude at all frequencies without a difference between trekkers with AMS and without AMS. DPOAE were evaluated also by Neri et al in seven subjects returning from an expedition to 6400 m [ 42 ]. During permanence at base camp, AMS symptoms were insignificant in all climbers, and none needed any medication.…”

Section: Resultsmentioning

confidence: 99%

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Auditory function in humans at high altitude. A scoping review

Masè,

Viziano,

Strapazzon

et al. 2023

PLoS ONE

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Purpose High-altitude (HA) affects sensory organ response, but its effects on the inner ear are not fully understood. The present scoping review aimed to collect the available evidence about HA effects on the inner ear with focus on auditory function. Methods The scoping review was conducted following the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis extension for scoping reviews. PubMed, Scopus, and Web of Science electronic databases were systematically searched to identify studies conducted in the last 20 years, which quantified in healthy subjects the effects of HA on auditory function. Results The systematic search identified 17 studies on a total population of 888 subjects (88.7% male, age: 27.8 ± 4.1 years; median sample size of 15 subjects). Nine studies were conducted in a simulated environment and eight during real expeditions at HA. To quantify auditory function, six studies performed pure tone audiometry, four studies measured otoacoustic emissions (OAE) and eight studies measured auditory evoked responses (AER). Study protocols presented heterogeneity in the spatio-temporal patterns of HA exposure, with highly varying maximal altitudes and exposure durations. Conclusion Most studies reported a reduction of auditory function with HA in terms of either elevation of auditory thresholds, lengthening of AER latencies, reduction of distortion-product and transient-evoked OAEs. Future studies in larger populations, using standardized protocols and multi-technique auditory function evaluation, are needed to further characterize the spatio-temporal pattern of HA effects along the auditory pathways and clarify the pathophysiological implications and reversibility of the observed changes.

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Section: Discussionmentioning

confidence: 71%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Auditory function in humans at high altitude. A scoping review

Masè,

Viziano,

Strapazzon

et al. 2023

PLoS ONE

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“…Environmental conditions and physical activity deeply influence general and/or organ-specific physiological responses. In humans, it is well known that acute or chronic exposure to high altitude (i.e., hypobaric hypoxia) can affect the nervous, cardiovascular, pulmonary, metabolic, and immune systems (Grocott et al, 2007;Hainsworth & Drinkhill, 2007;Doria et al, 2011;Mancinelli et al, 2011;Neri et al, 2014). These effects result from the influence of both different environmental parameters (e.g., absolute altitude, humidity, temperature, climatic conditions, duration of exposure) and organic conditions (e.g., nutrition, physical activity, acclimation, adaptation).…”

mentioning

confidence: 99%

Responses of peripheral blood mononuclear cells to moderate exercise and hypoxia

Morabito

Lanuti

Caprara

et al. 2015

Scandinavian Med Sci Sports

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The purpose of this study was to analyze the physiological features of peripheral blood mononuclear cells (PBMCs) isolated from healthy female trekkers before and after physical activity carried out under both normoxia (low altitude, < 2000 m a.s.l.) and hypobaric hypoxia (high altitude, > 3700 m a.s.l.). The experimental design was to differentiate effects induced by exercise and those related to external environmental conditions. PBMCs were isolated from seven female subjects before and after each training period. The PBMCs were phenotypically and functionally characterized using fluorimetric and densitometric analyses, to determine cellular activation, and their intracellular Ca(2+) levels and oxidative status. After a period of normoxic physical exercise, the PBMCs showed an increase in fully activated T lymphocytes (CD3(+) CD69(+) ) and a reduction in intracellular Ca(2+) levels. On the other hand, with physical exercise performed under hypobaric hypoxia, there was a reduction in T lymphocytes and an increase in nonactivated B lymphocytes, accompanied by a reduction in O2 (-) levels in the mitochondria. These outcomes reveal that in women, low- to moderate-intensity aerobic trekking induces CD69 T cell activation and promotes anti-stress effects on the high-altitude-induced impairment of the immune responses and the oxidative balance.

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