Heart-Muscle Magnesium, Potassium, and Zinc Concentrations After Sudden Death From Heart-Disease

Chipperfield, Barbara; Chipperfield, J. R.

doi:10.1016/s0140-6736(73)90796-4

Cited by 111 publications

(26 citation statements)

References 13 publications

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“…Magnesium deficiency, as assessed by decreased magnesium in the blood or tissues, and cardiovascular disease are linked [27,28]. In a recent review [29], none of the various circulating spasmogenic theories could satisfactorily account for coronary vasospasm in hyperthyroidism, and Miyagi et al [30] had shown magnesium to suppress coronary spastic angina.…”

Section: Discussionmentioning

confidence: 99%

Magnesium Metabolism in Hyperthyroidism.

et al. 1996

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Section: Discussionmentioning

confidence: 99%

Magnesium Metabolism in Hyperthyroidism.

et al. 1996

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“…1 The importance of magnesium has further been emphasized by autopsy studies demonstrating more coronary atherosclerosis and evidence of myocardial infarction in men from soft water areas 2 as well as low magnesium concentrations in cardiac tissue in patients who died from sudden cardiac death. 3 Also supporting the concept is the fact that experimentally induced magnesium deficiency changes the blood lipid composition in a more atherogenic direction. 4,5 Moreover, it has already been shown that magnesium supplementation is able to reduce the cholesterol deposition in the vessel wall in rabbits as well as in mice fed a high cholesterol diet.…”

mentioning

confidence: 93%

Oral Magnesium Supplementation Induces Favorable Antiatherogenic Changes in ApoE-Deficient Mice

Ravn

Korsholm

Falk

2001

ATVB

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Abstract-Epidemiological studies indicate that dietary magnesium influences atherogenesis. Magnesium inhibits plaque formation in animals receiving a high cholesterol diet, whereas the effect of magnesium in animals on low-fat diet has not been explored. Magnesium sulfate was given in the drinking water (50 mg/mL) to 7-week-old apolipoprotein E-deficient (apoE Ϫ/Ϫ ) mice (nϭ30). Control animals (nϭ30) received tap water. At the age of 19 weeks, the extent of atherosclerosis and the density of macrophages were measured in the aortic root, and blood lipids were analyzed. The median plaque area was significantly smaller in magnesium-treated female apoE Ϫ/Ϫ mice and reached only 66% of control females (PϽ0.02). Plaque area was also less extensive in magnesium-treated male mice, although not statistically significant. Macrophage density was similar in both groups. Magnesium significantly reduced cholesterol (PϽ0.05) and triglyceride (PϽ0.01) levels, whereas high density lipoprotein cholesterol remained stable. No significant differences in body and heart weight were seen between treatment groups for either sex. In conclusion, in apoE Ϫ/Ϫ mice receiving a low-fat diet, magnesium supplementation significantly inhibited atherogenesis in females but not males. Plaque composition remained unchanged in terms of macrophage density. This was obtained in association with significantly reduced levels of cholesterol and triglycerides.

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“…1,2 Epidemiological evidence that links magnesium deficiency to coronary artery disease (CAD) has been investigated for Ͼ3 decades. [3][4][5][6][7] In the Atherosclerosis Risk in Communities (ARIC) Study, 8 the relation of serum and dietary magnesium and CAD incidence during 4 to 7 years of follow-up was examined in a sample of 13 922 middle-aged adults free of baseline CAD from 4 US communities. After adjustment for traditional risk factors, the relative risk of CAD across quartiles of serum magnesium was 1.00, 0.92, 0.48, and 0.44 (P for trendϭ0.009), suggesting that low magnesium may be involved in the pathogenesis of CAD.…”

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Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease

et al. 2000

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Background-Magnesium blocks many of the physiological actions of calcium. Nevertheless, the impact of magnesium supplementation on endothelial function and exercise tolerance in stable coronary artery disease (CAD) patients has not been assessed. Methods and Results-In a randomized, double-blind, placebo-controlled trial, 50 stable CAD patients (41 men and 9 women, meanϮSD age 67Ϯ11 years, age range 42 to 82 years) were randomized to receive either magnesium (nϭ25) (30 mmol/d Magnosolv-Granulat; Asta Medica Company, Inc) or placebo (nϭ25) for 6 months. Before and after 6 months, endotheliumdependent brachial artery flow-mediated vasodilation (FMD) and endothelium-independent NTG-mediated vasodilation were assessed with high-resolution (10-MHz) ultrasound. Exercise stress testing was performed with use of the Bruce protocol. Intracellular magnesium concentrations ([Mg

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Heart-Muscle Magnesium, Potassium, and Zinc Concentrations After Sudden Death From Heart-Disease

Cited by 111 publications

References 13 publications

Magnesium Metabolism in Hyperthyroidism.

Magnesium Metabolism in Hyperthyroidism.

Oral Magnesium Supplementation Induces Favorable Antiatherogenic Changes in ApoE-Deficient Mice

Oral Magnesium Therapy Improves Endothelial Function in Patients With Coronary Artery Disease

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