Heart Rate Orcadian Rhythm as a Biological Marker of Desynchronization in Major Depression: A Methodological and Preliminary Report

Taillard, Jacques; Sanchez, Patrick; Lemoine, Patrick; Mouret, J

doi:10.3109/07420529009064636

Cited by 15 publications

(4 citation statements)

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“…Our work does not confirm the phase advance hypothesis of depression (Wehr et al, 1979), as suggested by others (Kripke, 1979;Tsujimoto et al, 1990;Taillard et al, 1992). Nevertheless, in depressed patients, it is possible that their estimation of diurnal preference may be partly biased by the sensation of malaise in the morning, which might in turn modify answers to those items involving morning status and performance (Taillard et al, 1990).…”

Section: Dependentcontrasting

confidence: 87%

Is Self-Reported Morbidity Related to the Circadian Clock?

et al. 2001

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Morningness and eveningness preference, an endogenous component of the circadian clock, is characterized by an interindividual difference in circadian phase and requires of humans a specific timing of behavior. The biological rhythms of morning and evening types are consequently phase shifted with fixed socioeconomic constraints. The impact of this phase shift on health is widely debated. The purpose of the authors' study was to determine the influence of morningness/eveningness preference on self-reported morbidity and health in an active population. A total of 1165 nonshift workers of the French national electrical and gas company, enrolled in the GAZEL cohort and aged 51.3+/-3.3 years, were included in this study. They replied by mail with a completed questionnaire, including morningness/eveningness preference, self-reported morbidity, subjective sleep patterns, and daytime somnolence and sleeping schedules for 3 weeks, during the spring of 1997. Annual self-reported health impairments were assessed with the annual general questionnaire of the GAZEL cohort for 1997. After adjustment for age, sex, and occupational status, morningness-like and eveningness-like participants reported a specific worse self-reported morbidity. Whereas morningness was associated with worse sleep (p = 0.0001), eveningness was associated with feeling less energetic (p = 0.04) and physical mobility (p = 0.02). These relationships were observed even in good sleepers, except for physical mobility. After adjustment for confounding variables, eveningness-like participants reported more sleep (p = 0.0004) and mood (p = 0.00018) disorders than morningness-like participants. Morningness/eveningness preference was related to specific chronic complaints of insomnia: morningness was related with difficulty in maintaining sleep (p = 0.0005) and the impossibility to return to sleep in the early morning (p = 0.0001) (sleep phase-advance syndrome); eveningness was related to difficulty in initiating sleep (p = 0.0001) and morning sleepiness (p = 0.0001). In good sleepers, morningness was related with sleep phase-advance syndrome (p = 0.0001) and eveningness with morning sleepiness (p = 0.0001). In conclusion, the expression (phase advance or delay) of the circadian clock could be related to worse self-reported morbidity and health. These findings must be verified by further epidemiological studies, but they suggest that the impossibility to return to sleep in the early morning is not only associated with age.

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Section: Dependentcontrasting

confidence: 87%

Is Self-Reported Morbidity Related to the Circadian Clock?

et al. 2001

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“…In the violent method group, an anticipated peak in the early afternoon hours was observed (acrophase: 14.31 vs. 16.05 hours for the non-violent method group), similar to the time period that has been found for suicide (7,8). This observation suggests the hypothesis that suicidal behaviours involving more violent methods more closely resemble failed suicide than parasuicide.…”

Section: Discussionsupporting

confidence: 66%

“…Considerable evidence has accumulated which indicates that several alterations in circadian rhythms occur in association with affective disorders and may play a relevant aetiological role. In particular, circadian anomalies have been documented with regard to body temperature ( 14), sleep pattern (15), heart rate ( 16), plasma and urinary cortisol ( 17 ), plasma prolactin ( 18 ) and melatonin (19). Other biochemical dysfunctions to be considered as possible candidates include either catecholamines (20-21) or serotonin (22-23).…”

Section: Discussionmentioning

confidence: 99%

Circadian rhythm of parasuicide in relation to violence if method and concomitant mental disorder

Caracciolo

Manfredini

Gallerani

1996

Acta Psychiatr Scand

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Circadian occurrence of parasuicide was evaluated in relation to sex, violence of parasuicide method and psychiatric diagnosis. In all, 457 consecutive episodes of parasuicide were recruited during a 5-year period. Complete data for time of parasuicide, parasuicide method, parasuicide recurrency and psychiatric diagnosis (ICD-9) were available for 304 subjects. Parasuicide methods were classified into two groups depending on the violence of the method. Parasuicide occurred significantly more often in the afternoon and evening hours for both men and women, for both violent and non-violent methods, both in first-even cases and repeaters, and in the following diagnostic groups: organic mental and psychoactive substance disorders, neurotic disorders and personality disorders. The data support the hypothesis of a circadian rhythmicity of parasuicide, showing an area of chronobiological risk in the afternoon and early evening hours.

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“…Morning types usually wake up several hours earlier than evening types, for example an average of 07:20 versus 09:20 in a study in England [12], although the full spread of chronotypes (95% confidence interval of the mean) was found to be about 6 hours in a more extensive study [13], indicating that most people wake up within a 6-hour window in the morning, with "larks" as early as 6 o'clock and "owls" as late as noon. Consistently with these differences in wake-up time, the daily rhythms of body temperature [1,14,15], heart rate [16,17], and melatonin secretion [15,[18][19][20] peak earlier in the day in morning types than in evening types. Morning types are more alert at wake-up time [3,21], are better at recognition of sentences presented in the morning than in the afternoon [22], are less stressed out by morning commute driving than evening types [23], and prefer having sex earlier in the day than evening types [24].…”

Section: Introductionmentioning

confidence: 81%

Exploring determinants of behavioral chronotype in a diurnal-rodent model of human physiology

Refinetti

Earle

Kenagy

2019

Physiology & Behavior

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Numerous studies conducted with human participants have shown that differences in chronotype, defined as individual patterns of early or late beginning of daily activity, have implications for many biobehavioral processes, such as cognitive performance, mood, impulsivity, academic achievement of college students, and mental health. However, the determinants of individual variation in chronotype have not been investigated. Basic research on circadian rhythms has provided a basis for investigating the causes of chronotype variation, but experimental tests of pertinent hypotheses are difficult to conduct with human subjects. This limitation can be overcome by use of animal models. This study was conducted with a rodent species, the antelope ground squirrel (Ammospermophilus leucurus), that, like humans, is active during the daytime, exhibits a spread of chronotypes, and has a similar average free-running circadian period. We found chronotype to be a stable trait within individuals based on strong consistency of separate determinations made six months apart (correlation r = 0.91). We also found a moderate correlation of chronotype with the duration of the active phase (r =-0.51) and with free running period (r = 0.34), but weak correlation with rhythm robustness (r = 0.16), and no correlation with photic responsiveness or with masking responses. The best multiple regression model, incorporating the duration of the active phase, free-running period, and rhythm robustness, explained 38% of the variance in chronotype. Although 62% of the variance in chronotype remained unaccounted for, the results are encouraging because they document the possibility of using a diurnal rodent as a model for the investigation of the determinants of chronotype variation in humans.

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Heart Rate Orcadian Rhythm as a Biological Marker of Desynchronization in Major Depression: A Methodological and Preliminary Report

Cited by 15 publications

References 0 publications

Is Self-Reported Morbidity Related to the Circadian Clock?

Is Self-Reported Morbidity Related to the Circadian Clock?

Circadian rhythm of parasuicide in relation to violence if method and concomitant mental disorder

Exploring determinants of behavioral chronotype in a diurnal-rodent model of human physiology

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