Heat Denaturation of Plasminogen in the Fibrin Plate Method.

Lassen, Mogens

doi:10.1111/j.1748-1716.1953.tb00951.x

Cited by 160 publications

(56 citation statements)

References 11 publications

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“…Although reduced to approximately one-half, this action is still detected on heat-denatured fibrin which, according to Lassen (1952), is no longer sensitive to plasminogen activators, but retains sensitivity to directly-acting proteolytic enzymes like plasmin. It has been suggested (Sherry et al, 1959), that free plasmin is rarely encountered in plasma, fibrinolytic activity being the result of the activation by circulating activators, of plasminogen adsorbed into fibrin.…”

Section: Discussionmentioning

confidence: 99%

Fibrinolytic activity evoked in the plasma of the normal and adrenalectomized rat by cellulose sulphate

Rosa

Rothschild

1972

British J Pharmacology

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Summary1. Cellulose sulphate, a kinin-releasing agent, produced fibrinolytic activity in plasma when administered intravenously to the rat but not when added to fresh rat plasma in vitro. The in viva effect was maximal within 1 min and disappeared within 10-20 minutes. It was retained in plasma taken 1 min after the injection and kept at room temperature for 30 minutes. 2. A decrease of anti-fibrinolytic potency measured against urokinaseactivated bovine plasmin, was shown to occur in plasma of rats given cellulose sulphate. 3. Activated rat plasma lysed heat-denatured fibrin: it probably contains free plasmin as well as plasminogen activator. 4. Adrenalectomized rats did not exhibit fibrinolytic activity nor statistically significant benzoyl-arginine ethyl ester-esterase activation in plasma after cellulose sulphate treatment. 5. Adrenalectomized rats had significantly increased levels of plasma kininogen, but were normally sensitive to the kininogen-depleting action of cellulose sulphate. 6. The increased plasma kininogen of adrenalectomized rats seems to be a consequence of the impairment of the plasminogen activating mechanism.

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Section: Discussionmentioning

confidence: 99%

Fibrinolytic activity evoked in the plasma of the normal and adrenalectomized rat by cellulose sulphate

Rosa

Rothschild

1972

British J Pharmacology

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“…Greater short-term differences in therapeutic response exist between control and fibrinolysin patients when analysis is restricted to Circulation, Volume XXI, March 1960 those treated within …”

Section: Discussionmentioning

confidence: 99%

“…The analysis of the "early treatment" subgroups was carried out to test the hypothesis that the age of the thrombus will influence responise of the phlebitie subject to fibrinoCirculation, Volume XXI, March 1960 lysin. If this were so, differences between the fibrinolysin and control subgroups should be greater than those that exist between the two total groups.…”

Section: Discussionmentioning

confidence: 99%

“…), 'arbitrary" results for duration of anticoagulation, bed rest, and hospital stay are also presented. These "arbitrary" results were derived as follows: the day on which all signs Circulation, Volime XXI, March 1960 PIBRINOLYSIN THEIRAPYV or symptoms of active phlebitis (pain, tenderniess, turgidity, heat of the extremity, anid systemic tenmperature elevation) had subsided was takeii as the starting point. In keeping with the protocol "arbitrary " ambulation represents this figure plus 2 days; "arbitrary" discontinuance of anticoagulant drugs, this figure plus 4 days; "arbitrary" discharge, this figure plus 6 days.…”

Section: Therapymentioning

confidence: 99%

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Fibrinolysin (Plasmin) Therapy in Acute Deep Thrombophlebitis

1960

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“…Heated plates, insensitive to plasniinogen activators, were also prepared (Lassen, 1953). Areas of lysis were calculated as the product of two diameters measured at right angles to each other.…”

Section: Methodsmentioning

confidence: 99%

Tissue Fibrinolytic Activity in Obesity

Grace

Goldrick

1969

Aust J Exp Biol Med

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Summary The fibrinolytic activity of adipose tissue from seven obese and seven lean subjects was studied by incubating biopsy samples on fibrin plates. The obese subjects had normal tissue fibrinolytic activity despite markedly depressed spontaneous blood fibrinolytic activity. There was no correlation between blood and tissue plasminogen activator levels. The tissue activator was associated with the blood vessels and supportive elements of the adipose samples and was not inhibited by the presence of fat cells.

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Heat Denaturation of Plasminogen in the Fibrin Plate Method.

Cited by 160 publications

References 11 publications

Fibrinolytic activity evoked in the plasma of the normal and adrenalectomized rat by cellulose sulphate

Fibrinolytic activity evoked in the plasma of the normal and adrenalectomized rat by cellulose sulphate

Fibrinolysin (Plasmin) Therapy in Acute Deep Thrombophlebitis

Tissue Fibrinolytic Activity in Obesity

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