To improve the thermal performance of electric vehicle batteries, a novel cooling system of liquid cold plates coupled with air flow channels (LCP-AFC) for battery thermal management was proposed. Three-dimensional models were established for simulation. The effects of five factors on the heat dissipation of the electric vehicle battery module were studied, which included the battery discharge rate, inlet temperature of cooling liquid, nanofluids, airflow velocity, liquid, and air flow directions. The results showed that the maximum temperature T max and temperature difference ΔT of the battery module under 1 C discharge rate could be reduced by 1.1°C and 0.92°C compared to the single liquid cooling. Comparing the LCP-AFC with single air cooling, the T max and ΔT of the battery module under 4 C discharge rate could be reduced by 18.74°C and 2.71°C. The temperature uniformity of the battery module was not satisfied with the inlet temperature of the cooling liquid, which was lower than 15°C. The heat transfer performance was improved by adding Al, Cu, or Ag nanoparticles into the deionized water. Among them, Ag-water nanofluid had the most significant cooling effect. Parallel flow indicated better thermal performance than cross flow and counter flow. The developed cooling system of LCP-AFC offers a new method to design lithiumion battery thermal management system for controlling temperature distribution of a battery module.